Neuroglobin-overexpression reduces traumatic brain lesion size in mice

BMC Neuroscience

Volumn 13, Issue 1, 2012, Pages

  Zhao, Song ^a,b   Yu, Zhanyang ^b   Zhao, Gang ^a   Xing, Changhong ^b   Hayakawa, Kazuhide ^b   Whalen, Michael J ^b   Lok, Josephine M ^b   Lo, Eng H ^b   Wang, Xiaoying ^b  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Controlled cortical impact; Neuroglobin; Neuroprotection; Oxidative stress; Traumatic brain injury

Indexed keywords

NEUROGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENE OVEREXPRESSION; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; SPATIAL MEMORY; TRAUMATIC BRAIN INJURY;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN INJURIES; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; GAIT DISORDERS, NEUROLOGIC; GENE EXPRESSION REGULATION; GLOBINS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; SEIZURES; SPACE PERCEPTION; TYROSINE;

EID: 84862162811     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-13-67     Document Type: Article

References (31)

1. Awenius C, Hankeln T, Burmester T. Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis. Biochem Biophys Res Commun 2001, 287(2):418-421. 10.1006/bbrc.2001.5614, 11554744.
2. Burmester T, Weich B, Reinhardt S, Hankeln T. A vertebrate globin expressed in the brain. Nature 2000, 407(6803):520-523. 10.1038/35035093, 11029004.
3. Burmester T, Hankeln T. Neuroglobin: a respiratory protein of the nervous system. News Physiol Sci 2004, 19:110-113.
4. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res 2009, 87(1):164-170. 10.1002/jnr.21826, 2631383, 18711728.
5. Wang X, Liu J, Zhu H, Tejima E, Tsuji K, Murata Y, Atochin DN, Huang PL, Zhang C, Lo EH. Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke 2008, 39(6):1869-1874. 10.1161/STROKEAHA.107.506022, 2727360, 18403737.
6. Khan AA, Wang Y, Sun Y, Mao XO, Xie L, Miles E, Graboski J, Chen S, Ellerby LM, Jin K, et al. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci USA 2006, 103(47):17944-17948. 10.1073/pnas.0607497103, 1693852, 17098866.
7. Khan AA, Mao XO, Banwait S, Jin K, Greenberg DA. Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. Proc Natl Acad Sci USA 2007, 104(48):19114-19119. 10.1073/pnas.0706167104, 2141917, 18025470.
8. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X. Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience 2009, 162(2):396-403. 10.1016/j.neuroscience.2009.04.055, 2787411, 19401220.
9. Jin K, Mao XO, Xie L, Khan AA, Greenberg DA. Neuroglobin protects against nitric oxide toxicity. Neurosci Lett 2008, 430(2):135-137. 10.1016/j.neulet.2007.10.031, 2265792, 18035490.
10. Khan AA, Mao XO, Banwait S, DerMardirossian CM, Bokoch GM, Jin K, Greenberg DA. Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J 2008, 22(6):1737-1747. 10.1096/fj.07-100784, 2746758, 18198211.
11. Yu Z, Fan X, Lo EH, Wang X. Neuroprotective roles and mechanisms of neuroglobin. Neurol Res 2009, 31(2):122-127. 10.1179/174313209X389866, 19298751.
12. Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, Dixon CE, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci 2000, 20(18):7037-7042.
13. Lok J, Leung W, Zhao S, Pallast S, van Leyen K, Guo S, Wang X, Yalcin A, Lo EH. gamma-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma. J Neurochem 2011, 118(2):248-255. 10.1111/j.1471-4159.2011.07294.x, 3285992, 21534958.
14. Sultana R, Butterfield DA. Slot-blot analysis of 3-nitrotyrosine-modified brain proteins. Methods Enzymol 2008, 440:309-316.
15. Deng Y, Thompson BM, Gao X, Hall ED. Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury. Exp Neurol 2007, 205(1):154-165. 10.1016/j.expneurol.2007.01.023, 1950332, 17349624.
16. Tsenter J, Beni-Adani L, Assaf Y, Alexandrovich AG, Trembovler V, Shohami E. Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions. J Neurotrauma 2008, 25(4):324-333. 10.1089/neu.2007.0452, 18373482.
17. Beni-Adani L, Gozes I, Cohen Y, Assaf Y, Steingart RA, Brenneman DE, Eizenberg O, Trembolver V, Shohami E. A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice. J Pharmacol Exp Ther 2001, 296(1):57-63.
18. Bermpohl D, You Z, Korsmeyer SJ, Moskowitz MA, Whalen MJ. Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome. J Cereb Blood Flow Metab 2006, 26(5):625-633. 10.1038/sj.jcbfm.9600258, 16395279.
19. Liu N, Yu Z, Xiang S, Zhao S, Tjarnlund-Wolf A, Xing C, Zhang J, Wang X. Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J 2012, 443(1):153-164. 10.1042/BJ20111856, 22239089.
20. Sun Y, Jin K, Peel A, Mao XO, Xie L, Greenberg DA. Neuroglobin protects the brain from experimental stroke in vivo. Proc Natl Acad Sci USA 2003, 100(6):3497-3500. 10.1073/pnas.0637726100, 152321, 12621155.
21. Lin X, Li M, Hu YZ, Han ZT, Zhang HH, Shang AJ, Gao DW, Zhou DB. An experimental research of neuroglobin expression changes and neural apoptosis after traumatic brain injury. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2010, 26(1):39-44.
22. Chuang PY, Conley YP, Poloyac SM, Okonkwo DO, Ren D, Sherwood PR, Hravnak M, Alexander SA. Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury. J Neurotrauma 2010, 27(6):999-1006. 10.1089/neu.2009.1129, 2943497, 20345238.
23. Shang A, Liu K, Wang H, Wang J, Hang X, Yang Y, Wang Z, Zhang C, Zhou D. Neuroprotective effects of neuroglobin after mechanical injury. Neurol Sci 2012, 33(3):551-558. 10.1007/s10072-011-0772-4, 21915648.
24. Jain KK. Neuroprotection in traumatic brain injury. Drug Discov Today 2008, 13(23-24):1082-1089.
25. Dirnagl U, Simon RP, Hallenbeck JM. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci 2003, 26(5):248-254. 10.1016/S0166-2236(03)00071-7, 12744841.
26. Wei X, Yu Z, Cho KS, Chen H, Malik MT, Chen X, Lo EH, Wang X, Chen DF. Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage. Am J Pathol 2011, 179(6):2788-2797. 10.1016/j.ajpath.2011.08.015, 21967817.
27. Jin K, Mao XO, Xie L, John V, Greenberg DA. Pharmacological induction of neuroglobin expression. Pharmacology 2011, 87(1-2):81-84. 3042117, 21228614.
28. Ansari MA, Roberts KN, Scheff SW. Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic Biol Med 2008, 45(4):443-452. 10.1016/j.freeradbiomed.2008.04.038, 2586827, 18501200.
29. Hall ED, Detloff MR, Johnson K, Kupina NC. Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury. J Neurotrauma 2004, 21(1):9-20. 10.1089/089771504772695904, 14987461.
30. Houdebine LM. The methods to generate transgenic animals and to control transgene expression. J Biotechnol 2002, 98(2-3):145-160.
31. Sijen T, Vijn I, Rebocho A, van Blokland R, Roelofs D, Mol JN, Kooter JM. Transcriptional and posttranscriptional gene silencing are mechanistically related. Curr Biol 2001, 11(6):436-440. 10.1016/S0960-9822(01)00116-6, 11301254.