Gamma-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma

Journal of Neurochemistry

Volumn 118, Issue 2, 2011, Pages 248-255

  Lok, Josephine ^a   Leung, Wendy ^a   Zhao, Song ^a,b   Pallast, Stefanie ^a   Van Leyen, Klaus ^a   Guo, Shuzhen ^a   Wang, Xiaoying ^a   Yalcin, Ayfer ^c   Lo, Eng H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c EGE UNIVERSITY   (Turkey)

Author keywords

blood brain barrier; endothelial; GCEE; glutathione; neuroprotection; oxidative stress

Indexed keywords

GAMMA GLUTAMYLCYSTEINE ETHYL ESTER; GLUTATHIONE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; OXIDATIVE STRESS; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; CAPILLARY PERMEABILITY; CELL LINE; DIPEPTIDES; ENDOTHELIAL CELLS; HUMANS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES;

EID: 79959985854     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07294.x     Document Type: Article

References (40)

1. Abbott N. J., Ronnback L., and, Hansson E., (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7, 41-53. (Pubitemid 41828930)
2. Andersen J. K., (2004) Oxidative stress in neurodegeneration: cause or consequence? Nat. Med., 10 (Suppl.), S18-S525.
3. Anderson M. E., and, Luo J. L., (1998) Glutathione therapy: from prodrugs to genes. Semin. Liver Dis. 18, 415-424. (Pubitemid 29011044)
4. Ayer R. E., and, Zhang J. H., (2008) Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm. Acta Neurochir. Suppl. 104, 33-41.
5. Besson V. C., (2009) Drug targets for traumatic brain injury from poly(ADP-ribose)polymerase pathway modulation. Br. J. Pharmacol. 157, 695-704.
6. Boyd-Kimball D., Sultana R., Poon H. F., Mohmmad-Abdul H., Lynn B. C., Klein J. B., and, Butterfield D. A., (2005) Gamma-glutamylcysteine ethyl ester protection of proteins from Abeta(1-42)-mediated oxidative stress in neuronal cell culture: a proteomics approach. J. Neurosci. Res. 79, 707-713. (Pubitemid 40476450)
7. Butterfield D. A., Pocernich C. B., and, Drake J., (2002) Elevated glutathione as a therapeutic strategy in Alzheimer's Disease. Drug Dev. Res. 56, 428-437. (Pubitemid 35168319)
8. Callahan M. K., Williams K. A., Kivisakk P., Pearce D., Stins M. F., and, Ransohoff R. M., (2004) CXCR3 marks CD4 + memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer. J. Neuroimmunol. 153, 150-157. (Pubitemid 38950937)
9. Chinta S. J., Rajagopalan S., Butterfield D. A., and, Andersen J. K., (2006) In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease. Neurosci. Lett. 402, 137-141. (Pubitemid 43766441)
10. Clark R. S., Bayir H., Chu C. T., Alber S. M., Kochanek P. M., and, Watkins S. C., (2008) Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy 4, 88-90.
11. Commandeur J. N., Stijntjes G. J., and, Vermeulen N. P., (1995) Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics. Pharmacol. Rev. 47, 271-330.
12. Drake J., Kanski J., Varadarajan S., Tsoras M., and, Butterfield D. A., (2002) Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress. J. Neurosci. Res. 68, 776-784. (Pubitemid 34594994)
13. Drake J., Sultana R., Aksenova M., Calabrese V., and, Butterfield D. A., (2003) Elevation of mitochondrial glutathione by gamma-glutamylcysteine ethyl ester protects mitochondria against peroxynitrite-induced oxidative stress. J. Neurosci. Res. 74, 917-927. (Pubitemid 37490425)
14. Dringen R., (2000) Metabolism and functions of glutathione in brain. Prog. Neurobiol. 62, 649-671. (Pubitemid 30407139)
15. Fernandez-Checa J. C., and, Kaplowitz N., (1990) The use of monochlorobimane to determine hepatic GSH levels and synthesis. Anal. Biochem. 190, 212-219. (Pubitemid 20371956)
16. Fernandez-Gomez F. J., Gomez-Lazaro M., Pastor D., Calvo S., Aguirre N., Galindo M. F., and, Jordan J., (2005) Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death. Neurobiol. Dis. 20, 384-391. (Pubitemid 41476264)
17. Hall E. D., Vaishnav R. A., and, Mustafa A. G., (2010) Antioxidant therapies for traumatic brain injury. Neurotherapeutics 7, 51-61.
18. Hawkins B. T., and, Davis T. P., (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57, 173-185. (Pubitemid 41043883)
19. Huet O., Cherreau C., Nicco C., et al. (2008) Pivotal role of glutathione depletion in plasma-induced endothelial oxidative stress during sepsis. Crit. Care Med. 36, 2328-2334.
20. Kamencic H., Lyon A., Paterson P. G., and, Juurlink B. H., (2000) Monochlorobimane fluorometric method to measure tissue glutathione. Anal. Biochem. 286, 35-37.
21. Kwon K. J., Kim H. J., Shin C. Y., and, Han S. H., (2010) Melatonin potentiates the neuroprotective properties of resveratrol against beta-amyloid-induced neurodegeneration by modulating AMP-activated protein kinase pathways. J. Clin. Neurol. 6, 127-137.
22. Lai Y., Hickey R. W., Chen Y., et al. (2008) Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J. Cereb. Blood Flow Metab. 28, 540-550. (Pubitemid 351304265)
23. Lok J., Gupta P., Guo S., Kim W. J., Whalen M. J., van Leyen K., and, Lo E. H., (2007) Cell-cell signaling in the neurovascular unit. Neurochem. Res. 32, 2032-2045. (Pubitemid 350059847)
24. Meister A., and, Anderson M. E., (1983) Glutathione. Annu. Rev. Biochem. 52, 711-760. (Pubitemid 13030692)
25. Mustafa A. G., Singh I. N., Wang J., Carrico K. M., and, Hall E. D., (2010) Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals. J. Neurochem. 114, 271-280.
26. Nishida K., Ohta Y., Ito M., Nagamura Y., Kitahara S., Fujii K., and, Ishiguro I., (1996) Conversion of gamma-glutamylcysteinylethyl ester to glutathione in rat hepatocytes. Biochim. Biophys. Acta 1313, 47-53. (Pubitemid 26276237)
27. Perry T. L., and, Yong V. W., (1986) Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. Neurosci. Lett. 67, 269-274. (Pubitemid 16038336)
28. Perry T. L., Godin D. V., and, Hansen S., (1982) Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci. Lett. 33, 305-310. (Pubitemid 13119539)
29. Pun P. B., Lu J., and, Moochhala S., (2009) Involvement of ROS in BBB dysfunction. Free Radic. Res. 43, 348-364.
30. Reed T. T., Owen J., Pierce W. M., Sebastian A., Sullivan P. G., and, Butterfield D. A., (2009) Proteomic identification of nitrated brain proteins in traumatic brain-injured rats treated postinjury with gamma-glutamylcysteine ethyl ester: insights into the role of elevation of glutathione as a potential therapeutic strategy for traumatic brain injury. J. Neurosci. Res. 87, 408-417.
31. Roberts R. A., Laskin D. L., Smith C. V., Robertson F. M., Allen E. M., Doorn J. A., and, Slikker W., (2009) Nitrative and oxidative stress in toxicology and disease. Toxicol. Sci. 112, 4-16.
32. Schulz J. B., Lindenau J., Seyfried J., and, Dichgans J., (2000) Glutathione, oxidative stress and neurodegeneration. Eur. J. Biochem. 267, 4904-4911. (Pubitemid 30641286)
33. Sebastia J., Cristofol R., Martin M., Rodriguez-Farre E., and, Sanfeliu C., (2003) Evaluation of fluorescent dyes for measuring intracellular glutathione content in primary cultures of human neurons and neuroblastoma SH-SY5Y. Cytometry A 51, 16-25. (Pubitemid 37517307)
34. Shrieve D. C., Bump E. A., and, Rice G. C., (1988) Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis. J. Biol. Chem. 263, 14107-14114.
35. Simard M., and, Nedergaard M., (2004) The neurobiology of glia in the context of water and ion homeostasis. Neuroscience 129, 877-896. (Pubitemid 39556241)
36. Sun X., Shih A. Y., Johannssen H. C., Erb H., Li P., and, Murphy T. H., (2006) Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface. J. Biol. Chem. 281, 17420-17431.
37. Turunc E., Kanit L., and, Yalcin A., (2010) Effect of gamma-glutamylcysteine ethylester on the levels of c-fos mRNA expression, glutathione and reactive oxygen species formation in kainic acid excitotoxicity. J. Pharm. Pharmacol. 62, 1010-1017.
38. Yalcin A., Armagan G., Turunc E., Konyalioglu S., and, Kanit L., (2010) Potential neuroprotective effect of gamma-glutamylcysteine ethyl ester on rat brain against kainic acid-induced excitotoxicity. Free Radic. Res. 44, 513-521.
39. You Z., Yang J., Takahashi K., et al. (2007) Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4. J. Cereb. Blood Flow Metab. 27, 1954-1964. (Pubitemid 350129164)
40. Zlokovic B. V., (2005) Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 28, 202-208. (Pubitemid 40445527)