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Diastereoisomeric dihydronaphthazepines incorporating an α-methylbenzylamine fragment have been shown to be separable via silica gel chromatography, see
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Qualitative analyses of potential ion-pair structures between the (aS)-2 and both E- and Z-enolate of the glycine imine were performed using DFT calculations (B3LYP/6-31G*). Because of the size of the structures involved it is not possible to provide an accurate estimation of ground state or interaction energies for these ion-pairs See for example
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