Insonation of targeted microbubbles produces regions of reduced blood flow within tumor vasculature

Investigative Radiology

Volumn 47, Issue 7, 2012, Pages 398-405

  Hu, Xiaowen ^a   Kheirolomoom, Azadeh ^a   Mahakian, Lisa M ^a   Beegle, Julie R ^a   Kruse, Dustin E ^a   Lam, Kit S ^b   Ferrara, Katherine W ^a  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

bound targeted microbubbles; microbubble fragmentation; molecular imaging; platelet aggregation; tumor vasculature

Indexed keywords

CYCLIC ARGININE GLYCINE ASPARTIC ACID; CYCLIC ASPARTIC ACID GLYCINE TYROSINE GLYCINE HYDROXYPROLINE ASPARAGINE; FLUORESCEIN ISOTHIOCYANATE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DELETION MUTANT; ENDOTHELIUM CELL; EXTRAVASATION; FEMALE; HIGH PRESSURE INSONATION; MICROBUBBLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOLOGICAL PROCEDURES; THROMBOCYTE ACTIVATION; THROMBOGENESIS; TUMOR BLOOD FLOW; TUMOR MODEL; TUMOR VASCULARIZATION;

EID: 84862139098     PISSN: 00209996     EISSN: 15360210     Source Type: Journal    
DOI: 10.1097/RLI.0b013e31824bd237     Document Type: Article

References (32)

1. Feril LB Jr, Kondo T. Biological effects of low intensity ultrasound: the mechanism involved, and its implications on therapy and on biosafety of ultrasound. J Radiat Res (Tokyo). 2004;45:479-489. (Pubitemid 40255920)
2. Brayman AA, Lizotte LM, Miller MW. Erosion of artificial endothelia in vitro by pulsed ultrasound: acoustic pressure, frequency, membrane orientation and microbubble contrast agent dependence. Ultrasound Med Biol. 1999;25: 1305-1320. (Pubitemid 29465804)
3. Miller DL, Quddus J. Lysis and sonoporation of epidermoid and phagocytic monolayer cells by diagnostic ultrasound activation of contrast agent gas bodies. Ultrasound Med Biol. 2001;27:1107-1113. (Pubitemid 32807733)
4. Stieger SM, Caskey CF, Adamson RH, et al. Enhancement of vascular permeability with low-frequency contrast-enhanced ultrasound in the chorioallantoic membrane model. Radiology. 2007;243:112-121. (Pubitemid 46579701)
5. Miller DL. Overview of experimental studies of biological effects of medical ultrasound caused by gas body activation and inertial cavitation. Prog Biophys Mol Biol. 2007;93:314-330. (Pubitemid 44809394)
6. ter Haar G. Safety and bio-effects of ultrasound contrast agents. Med Biol Eng Comput. 2009;47:893-900.
7. Miller DL, Dou C, Wiggins RC. Frequency dependence of kidney injury induced by contrast-aided diagnostic ultrasound in rats. Ultrasound Med Biol. 2008;34:1678-1687.
8. Bing KF, Howles GP, Qi Y, et al. Blood-brain barrier (BBB) disruption using a diagnostic ultrasound scanner and Definity in mice. Ultrasound Med Biol. 2009;35:1298-1308.
9. Miller DL, Pislaru SV, Greenleaf JE. Sonoporation: mechanical DNA delivery by ultrasonic cavitation. Somatic Cell Mol Genet. 2002;27:115-134. (Pubitemid 36553831)
10. Miller DL, Quddus J. Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture inmice. Proc Natl Acad SciUSA. 2000;97:10179-10184.
11. Skyba DM, Price RJ, Linka AZ, et al. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation. 1998;98:290-293. (Pubitemid 28348049)
12. Jimenez C, de Gracia R, Aguilera A, et al. In situ kidney insonation with microbubble contrast agents does not cause renal tissue damage in a porcine model. J Ultrasound Med. 2008;27:1607-1615.
13. Barnett SB, Rott HD, ter Haar GR, et al. The sensitivity of biological tissue to ultrasound. Ultrasound Med Biol. 1997;23:805-812. (Pubitemid 27349527)
14. Chin C, Raju BI, Shevchenko T, et al. Control and reversal of tumor growth by ultrasound activated microbubbles. IEEE Ultrason Symp. 2009;2009:77-80.
15. Goertz D, Karshafian R, Hynynen K. Investigating the effects of pulsed low intensity ultrasound and microbubbles in mouse tumors. IEEE Ultrason Symp. 2009;2009:89-92.
16. Wood AK, Bunte RM, Schultz SM, et al. Acute increases in murine tumor echogenicity after antivascular ultrasound therapy: a pilot preclinical study. J Ultrasound Med. 2009;28:795-800.
17. Wood AK, Schultz SM, Lee WM, et al. Antivascular ultrasound therapy extends survival of mice with implanted melanomas. Ultrasound Med Biol. 2010;36:853-857.
18. Guenther F, von zur Muhlen C, Ferrante EA, et al. An ultrasound contrast agent targeted to P-selectin detects activated platelets at supra-arterial shear flow conditions. Invest Radiol. 2010;45:586-591.
19. Anderson CR, Rychak JJ, Backer M, et al. scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis. Invest Radiol. 2010;45:579-585.
20. Pochon S, Tardy I, Bussat P, et al. BR55: a lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis. Invest Radiol. 2010;45:89-95.
21. Borowsky AD, Namba R, Young LJ, et al. Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior. Clin Exp Metastasis. 2005;22:47-59. (Pubitemid 41185861)
22. Siegel PM, Ryan ED, Cardiff RD, et al. Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J. 1999;18: 2149-2164. (Pubitemid 29179172)
23. Kheirolomoom A, Dayton PA, Lum AF, et al. Acoustically-active microbubbles conjugated to liposomes: characterization of a proposed drug delivery vehicle. J Control Release. 2007;118:275-284. (Pubitemid 46441545)
24. Anderson CR, Hu X, Zhang H, et al. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol. 2011;46:215-224.
25. Yao N, XiaoW,Wang X, et al. Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method. J Med Chem. 2009;52:126-133.
26. Kim MH, Curry FR, Simon SI. Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding. Am J Physiol Cell Physiol. 2009;296:C848YC856.
27. Wood AK, Bunte RM, Cohen JD, et al. The antivascular action of physiotherapy ultrasound on a murine tumor: role of a microbubble contrast agent. Ultrasound Med Biol. 2007;33:1901-1910. (Pubitemid 350236539)
28. Ross R, Glomset J, Harker L. Response to injury and atherogenesis. Am J Pathol. 1977;86:675-684. (Pubitemid 8063546)
29. Steele PM, Chesebro JH, Stanson AW, et al. Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model. Circ Res. 1985;57:105-112. (Pubitemid 15238846)
30. Davis C, Fischer J, Ley K, et al. The role of inflammation in vascular injury and repair. J Thromb Haemost. 2003;1:1699-1709.
31. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249-257.
32. Hu X, Zheng H, Kruse DE, et al. A sensitive TLRH targeted imaging technique for ultrasonic molecular imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2010;57:305-316.