Physical contact with endothelial cells through β1- and β2- integrins rescues chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis and induces a peculiar gene expression profile in leukemic cells

Haematologica

Volumn 97, Issue 6, 2012, Pages 952-960

  Maffei, Rossana ^a   Fiorcari, Stefania ^a   Bulgarelli, Jenny ^a   Martinelli, Silvia ^a   Castelli, Ilaria ^a   Deaglio, Silvia ^b   Debbia, Giulia ^a   Fontana, Marcella ^a   Coluccio, Valeria ^a   Bonacorsi, Goretta ^a   Zucchini, Patrizia ^a   Narni, Franco ^a   Torelli, Giuseppe ^a   Luppi, Mario ^a   Marasca, Roberto ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Cell adhesion; Chronic lymphocytic leukemia; Endothelial cells; Microenvironment

Indexed keywords

ALPHA4 INTEGRIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; BETA1 INTEGRIN; BETA2 INTEGRIN; CD18 ANTIGEN; CYTOKINE; ENDOGLIN; ENDOTHELIN 1; FLUDARABINE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; SURVIVIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN C; WNT PROTEIN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL INTERACTION; CELL SURVIVAL; CELL VIABILITY; CHRONIC LYMPHATIC LEUKEMIA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE BIOPSY; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE;

ANTIBODIES, NEUTRALIZING; ANTIGENS, CD18; ANTIGENS, CD29; ANTINEOPLASTIC AGENTS; APOPTOSIS; B-LYMPHOCYTES; CELL ADHESION; CELL COMMUNICATION; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; NEOPLASM PROTEINS; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; VASCULAR CELL ADHESION MOLECULE-1; VIDARABINE;

EID: 84862121791     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.054924     Document Type: Article

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