VIP Regulates the Development & Proliferation of Treg in vivo in spleen

Allergy, Asthma and Clinical Immunology

Volumn 7, Issue 1, 2011, Pages

  Szema, Anthony M ^a,b   Hamidi, Sayyed A ^a,b   Golightly, Marc G ^a   Rueb, Todd P ^a   Chen, John J ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; IMMUNOREGULATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SPLEEN; THYMUS;

EID: 84862120242     PISSN: 17101484     EISSN: 17101492     Source Type: Journal    
DOI: 10.1186/1710-1492-7-19     Document Type: Article

References (21)

1. Said SI. Vasoactive intestinal polypeptide (VIP): current status. Peptides 1984, 5(2):143-50. 10.1016/0196-9781(84)90197-9, 6147814.
2. Said SI, et al. Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene. Circulation 2007, 115:1260-1268.
3. Li JM, Southerland L, Hossain MS, Giver CR, Wang Y, Darlak K, Harris W, Waschek J, Waller EK. Absence of vasoactive intestinal Peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice. J Immunol 2011, 187(2):1057-65. 10.4049/jimmunol.1100686, 21677142.
4. Yu R, Zhang H, Huang L, Liu X, Chen J. Anti-hyperglycemic, antioxidant and anti-inflammatory effects of VIP and a VPAC1 agonist on streptozotocin-induced diabetic mice. Peptides 2011, 32(2):216-22. 10.1016/j.peptides.2010.11.017, 21129425.
5. Deng S, Xi Y, Wang H, Hao J, Niu X, Li W, Tao Y, Chen G. Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis. Cell Immunol 2010, 265(2):105-10. 10.1016/j.cellimm.2010.07.010, 20716449.
6. Jimeno R, Leceta J, Martínez C, Gutiérrez-Cañas I, Pérez-García S, Carrión M, Gomariz RP, Juarranz Y. Effect of VIP on the balance between cytokines and master regulators of activated helper T cells. Immunol Cell Biol 2011,
7. Wang Y, Mei Y, Bao S, Xu L. Vasoactive intestinal polypeptide enhances oral tolerance by regulating both cellular and humoral immune responses. Clin Exp Immunol 2007, 148(1):178-87. 10.1111/j.1365-2249.2007.03322.x, 1868860, 17349016.
8. Larocca L, Hauk V, Calafat M, Roca V, Fraccaroli L, Franchi A, Ramhorst R, Leirós CP. Modulation of macrophage inflammatory profile in pregnant nonobese diabetic (NOD) mice. Mol Cell Endocrinol 2011, 333(2):112-8. 10.1016/j.mce.2010.11.035, 21145370.
9. Camelo S, Lajavardi L, Bochot A, Goldenberg B, Naud MC, Brunel N, Lescure B, Klein C, Fattal E, Behar-Cohen F, de Kozak Y. Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis. J Ocul Pharmacol Ther 2009, 25(1):9-21. 10.1089/jop.2008.0074, 19232006.
10. Delgado M, Chorny A, Gonzalez-Rey E, Ganea D. Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo. J Leukoc Biol 2005, 78:1327-1338. 10.1189/jlb.0605299, 16204628.
11. Szema AM, et al. Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP. Am J Physiol Lung Cell Mol Physiol 2006, 291:L880-886. 10.1152/ajplung.00499.2005, 16782752.
12. Delgado M, Gonzalez-Rey E, Ganea D. The neuropeptide vasoactive intestinal peptide generates tolerogenic dendritic cells. J Immunol 2005, 175:7311-7324.
13. Bluestone JA, Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity?. Curr Opin Immunol 2005, 17:638-642. 10.1016/j.coi.2005.09.002, 16209918.
14. Fehervari Z, Sakaguchi S. CD4+ Tregs and immune control. J Clin Invest 2004, 114:1209-1217. 524236, 15520849.
15. Prasse A, et al. Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis. Am J Respir Crit Care Med 2010, 182:540-548. 10.1164/rccm.200909-1451OC, 20442436.
16. Thornton AM, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 184:3433-3441.
17. Gonzalez-Rey E, Delgado M. Vasoactive intestinal peptide and regulatory T-cell induction: a new mechanism and therapeutic potential for immune homeostasis. Trends Mol Med 2007, 13:241-251. 10.1016/j.molmed.2007.04.003, 17467339.
18. Nakashima H, et al. CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions. J Immunol 2010, 184:4637-4645. 10.4049/jimmunol.0901719, 20335532.
19. Tan YV, et al. Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2009, 106:2012-2017. 10.1073/pnas.0812257106, 2644155, 19190179.
20. Gonzalez-Rey E, Delgado M. Vasoactive intestinal peptide and regulatory T-cell induction: a new mechanism and therapeutic potential for immune homeostasis. Trends Mol Med 2007, 13:241-251. 10.1016/j.molmed.2007.04.003, 17467339.
21. Colwell CS, Michel S, Itri I, Rodriguez W, Tam I, Lelievre V, Hu Z, Liu X, Waschek JA. Disrupted circadian rhythms in VIP and PHI deficeint mice. Am J Physiol Regul Integr Comp Physiol 2003, 285:R939-R949.