Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial

Journal of Acquired Immune Deficiency Syndromes

Volumn 60, Issue 2, 2012, Pages 124-127

  Mureithi, Marianne W ^a,b   Poole, Danielle ^a,b   Naranbhai, Vivek ^a,c   Reddy, Shabashini ^a   Mkhwanazi, Nompumelelo P ^a   Sibeko, Sengeziwe ^c   Werner, Lise ^c   Karim, Quarraisha Abdool ^c,d   Karim, Salim Abdool ^c,d   Ndung'u, Thumbi ^a,b   Altfeld, Marcus ^a,b  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

HIV 1; HIV 1 specific CD4+ T cell help; Tenofovir; Vaginal microbicide

Indexed keywords

GAG PROTEIN; GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MICROBICIDE; PLACEBO; TENOFOVIR;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOMODULATION; INNATE IMMUNITY; PRIORITY JOURNAL; VIRUS IMMUNITY;

ADENINE; ADULT; ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON-GAMMA; PHOSPHONIC ACIDS; SOUTH AFRICA; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 84862117178     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31824f53a9     Document Type: Article

References (22)

1. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-1174.
2. Excler JL, Rida W, Priddy FH, et al. AIDS vaccines and pre-exposure prophylaxis: is synergy possible? AIDS Res Hum Retroviruses. 2011;27: 669-680.
3. Meier A, Chang JJ, Chan ES, et al. Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat Med. 2009;15:955-959.
4. Meier A, Fisher A, Sidhu HK, et al. Rapid loss of dendritic cell and monocyte responses to TLR ligands following venipuncture. J Immunol Methods. 2008;339:132-140.
5. Alter G, Suscovich TJ, Teigen N, et al. Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells. J Immunol. 2007; 178:7658-7666. (Pubitemid 46898036)
6. Mkhwanazi N, Thobakgale CF, van der Stok M, et al. Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality. Virology. 405:483-491.
7. Thobakgale CF, Ramduth D, Reddy S, et al. Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants. J Virol. 2007;81:12775-12784. (Pubitemid 350156915)
8. Rosenberg ES, Altfeld M, Poon SH, et al. Immune control of HIV-1 after early treatment of acute infection. Nature. 2000;407:523-526.
9. Alter G, Teigen N, Ahern R, et al. Evolution of innate and adaptive effector cell functions during acute HIV-1 infection. J Infect Dis. 2007; 195:1452-1460. (Pubitemid 46717463)
10. Alter G, Teigen N, Davis BT, et al. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood. 005;106:3366-3369.
11. Sabado RL, O'Brien M, Subedi A, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood. 2010;116:3839-3852.
12. Pacanowski J, Kahi S, Baillet M, et al. Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in primary HIV-1 infection. Blood. 2001;98:3016-3021.
13. Deeks SG, Walker BD. The immune response to AIDS virus infection: good, bad, or both? J Clin Invest. 2004;113:808-810. (Pubitemid 38544138)
14. Virgin HW, Walker BD. Immunology and the elusive AIDS vaccine. Nature. 2010;464:224-231.
15. Gloster SE, Newton P, Cornforth D, et al. Association of strong virusspecific CD4 T cell responses with efficient natural control of primary HIV-1 infection. AIDS. 2004;18:749-755. (Pubitemid 38535002)
16. Altfeld M, Rosenberg ES, Shankarappa R, et al. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J Exp Med. 2001;193:169-180. (Pubitemid 32524449)
17. Lichterfeld M, Kaufmann DE, Yu XG, et al. Loss of HIV-1-specific CD8+T cell proliferation after acute HIV-1 infection and restoration by vaccine- induced HIV-1-specific CD4+ T cells. J Exp Med. 2004;200: 701-712. (Pubitemid 39299457)
18. Oxenius A, Price DA, Trkola A, et al. Loss of viral control in early HIV-1 infection is temporally associated with sequential escape from CD8+ T cell responses and decrease in HIV-1-specific CD4+ and CD8+ T cell frequencies. J Infect Dis. 2004;190:713-721. (Pubitemid 39050001)
19. Streeck H, Jolin JS, Qi Y, et al. Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells. J Virol. 2009;83:7641-7648.
20. Streeck H, Nixon DF. T cell immunity in acute HIV-1 infection. J Infect Dis. 2010;202(suppl 2):S302-S308.
21. Brenchley JM, Schacker TW, Ruff LE, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200:749-759. (Pubitemid 39299461)
22. Douek DC, Brenchley JM, Betts MR, et al. HIV preferentially infects HIV-specific CD4+ T cells. Nature. 2002;417:95-98. (Pubitemid 34498823)