Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Alberti, Michael O ^a,b   Roth, Justin C ^a,b,d   Ismail, Mourad ^c   Tsuruta, Yuko ^a   Abraham, Edward ^a   Pereboeva, Larisa ^a,b   Gerson, Stanton L ^c   Curiel, David T ^a,b,e  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d University of Alabama at Birmingham   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CAPSID PROTEIN; MYELOID BINDING PEPTIDE; PEPTIDE; TRYPTOPHANYLTHREONYLLEUCYLASPARTYLARGINYLGLYCYLTYROSINE; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT;

ADENOVIRUS; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CELL TYPE; CONTROLLED STUDY; DERIVATIZATION; GENE TARGETING; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NONHUMAN; PHAGE DISPLAY; PROTEIN EXPRESSION; TARGET CELL; VIRAL GENE DELIVERY SYSTEM; ANIMAL; C57BL MOUSE; CELL STRAIN HEK293; FLOW CYTOMETRY; GENE VECTOR; GENETICS; METABOLISM; METHODOLOGY; PEPTIDE LIBRARY; PROTEIN BINDING; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ADENOVIRIDAE; MIRIDAE;

ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; FLOW CYTOMETRY; GENE THERAPY; GENETIC VECTORS; HEK293 CELLS; HUMANS; INFLAMMATION; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; MYELOID CELLS; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PROTEIN BINDING;

EID: 84862102122     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037812     Document Type: Article

References (37)

1. Waehler R, Russell SJ, Curiel DT, (2007) Engineering targeted viral vectors for gene therapy. Nat Rev Genet 8: 573-587.
2. Krasnykh VN, Douglas JT, van Beusechem VW, (2000) Genetic targeting of adenoviral vectors. Mol Ther 1: 391-405.
3. Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, et al. (1997) Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275: 1320-1323.
4. Wickham TJ, Mathias P, Cheresh DA, Nemerow GR, (1993) Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73: 309-319.
5. Douglas JT, Rogers BE, Rosenfeld ME, Michael SI, Feng M, et al. (1996) Targeted gene delivery by tropism-modified adenoviral vectors. Nat Biotechnol 14: 1574-1578.
6. Haisma HJ, Grill J, Curiel DT, Hoogeland S, van Beusechem VW, et al. (2000) Targeting of adenoviral vectors through a bispecific single-chain antibody. Cancer Gene Ther 7: 901-904.
7. Watkins SJ, Mesyanzhinov VV, Kurochkina LP, Hawkins RE, (1997) The 'adenobody' approach to viral targeting: specific and enhanced adenoviral gene delivery. Gene Ther 4: 1004-1012.
8. Magnusson MK, Hong SS, Henning P, Boulanger P, Lindholm L, (2002) Genetic retargeting of adenovirus vectors: functionality of targeting ligands and their influence on virus viability. J Gene Med 4: 356-370.
9. Hedley SJ, Auf der Maur A, Hohn S, Escher D, Barberis A, et al. (2006) An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery. Gene Ther 13: 88-94.
10. Krasnykh V, Dmitriev I, Mikheeva G, Miller CR, Belousova N, et al. (1998) Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob. J Virol 72: 1844-1852.
11. Dmitriev I, Krasnykh V, Miller CR, Wang M, Kashentseva E, et al. (1998) An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol 72: 9706-9713.
12. Mizuguchi H, Koizumi N, Hosono T, Utoguchi N, Watanabe Y, et al. (2001) A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob. Gene Ther 8: 730-735.
13. Roelvink PW, Mi Lee G, Einfeld DA, Kovesdi I, Wickham TJ, (1999) Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae. Science 286: 1568-1571.
14. Nicklin SA, Von Seggern DJ, Work LM, Pek DC, Dominiczak AF, et al. (2001) Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus. Mol Ther 4: 534-542.
15. Myhre S, Henning P, Granio O, Tylo AS, Nygren PA, et al. (2007) Decreased immune reactivity towards a knobless, affibody-targeted adenovirus type 5 vector. Gene Ther 14: 376-381.
16. Parker AL, Waddington SN, Nicol CG, Shayakhmetov DM, Buckley SM, et al. (2006) Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes. Blood 108: 2554-2561.
17. Waddington SN, McVey JH, Bhella D, Parker AL, Barker K, et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell 132: 397-409.
18. Shayakhmetov DM, Gaggar A, Ni S, Li ZY, Lieber A, (2005) Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity. J Virol 79: 7478-7491.
19. Krasnykh V, Belousova N, Korokhov N, Mikheeva G, Curiel DT, (2001) Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J Virol 75: 4176-4183.
20. Noureddini SC, Krendelshchikov A, Simonenko V, Hedley SJ, Douglas JT, et al. (2006) Generation and selection of targeted adenoviruses embodying optimized vector properties. Virus Res 116: 185-195.
21. Magnusson MK, Hong SS, Boulanger P, Lindholm L, (2001) Genetic retargeting of adenovirus: novel strategy employing "deknobbing" of the fiber. J Virol 75: 7280-7289.
22. van Beusechem VW, van Rijswijk AL, van Es HH, Haisma HJ, Pinedo HM, et al. (2000) Recombinant adenovirus vectors with knobless fibers for targeted gene transfer. Gene Ther 7: 1940-1946.
23. Glasgow JN, Mikheeva G, Krasnykh V, Curiel DT, (2009) A strategy for adenovirus vector targeting with a secreted single chain antibody. PLoS One 4: e8355.
24. Ulasov IV, Tyler MA, Han Y, Glasgow JN, Lesniak MS, (2007) Novel recombinant adenoviral vector that targets the interleukin-13 receptor alpha2 chain permits effective gene transfer to malignant glioma. Hum Gene Ther 18: 118-129.
25. Nathan C, Ding A, (2010) Nonresolving inflammation. Cell 140: 871-882.
26. Pasqualini R, Ruoslahti E, (1996) Organ targeting in vivo using phage display peptide libraries. Nature 380: 364-366.
27. Rajotte D, Arap W, Hagedorn M, Koivunen E, Pasqualini R, et al. (1998) Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display. J Clin Invest 102: 430-437.
28. Korokhov N, Mikheeva G, Krendelshchikov A, Belousova N, Simonenko V, et al. (2003) Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge. J Virol 77: 12931-12940.
29. Tallone T, Malin S, Samuelsson A, Wilbertz J, Miyahara M, et al. (2001) A mouse model for adenovirus gene delivery. Proc Natl Acad Sci U S A 98: 7910-7915.
30. Belousova N, Korokhov N, Krendelshchikova V, Simonenko V, Mikheeva G, et al. (2003) Genetically targeted adenovirus vector directed to CD40-expressing cells. J Virol 77: 11367-11377.
31. Chartier C, Degryse E, Gantzer M, Dieterle A, Pavirani A, et al. (1996) Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J Virol 70: 4805-4810.
32. Belousova N, Krendelchtchikova V, Curiel DT, Krasnykh V, (2002) Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein. J Virol 76: 8621-8631.
33. Murakami M, Ugai H, Wang M, Belousova N, Dent P, et al. (2010) An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations. Virology 407: 196-205.
34. Maizel JV Jr, White DO, Scharff MD, (1968) The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12. Virology 36: 115-125.
35. Snelgrove RJ, Jackson PL, Hardison MT, Noerager BD, Kinloch A, et al. (2010) A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 330: 90-94.
36. Douglas JT, Miller CR, Kim M, Dmitriev I, Mikheeva G, et al. (1999) A system for the propagation of adenoviral vectors with genetically modified receptor specificities. Nat Biotechnol 17: 470-475.
37. Tsuruta Y, Park YJ, Siegal GP, Liu G, Abraham E, (2007) Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. J Immunol 179: 7079-7086.