Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Zheng, Min ^a   Lv, Lin Li ^a   Ni, Jie ^a   Ni, Hai Feng ^a   Li, Qing ^a   Ma, Kun Ling ^a   Liu, Bi Cheng ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALBUMIN; ALPHA ACTIN4; BIOLOGICAL MARKER; CD2 ASSOCIATED PROTEIN; CREATININE; MESSENGER RNA; PODOCALYXIN; PODOCIN; SYNAPTOPODIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; ACTININ; ACTN4 PROTEIN, HUMAN; CD2-ASSOCIATED PROTEIN; CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; SIALOGLYCOPROTEIN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SYNPO PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DISEASE COURSE; FEMALE; GENE EXPRESSION; GLOMERULUS FILTRATION RATE; HUMAN; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INVASIVE MEASUREMENT; PATHOGENESIS; PATIENT CODING; PODOCYTE; PROTEIN ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STAGING; UREA NITROGEN BLOOD LEVEL; URINE SEDIMENT; BLOOD; GENETICS; METABOLISM; MIDDLE AGED; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; URINE;

ACTININ; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; CREATININE; CYTOSKELETAL PROTEINS; DIABETIC NEPHROPATHIES; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MIDDLE AGED; PODOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIALOGLYCOPROTEINS;

EID: 79957789587     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020431     Document Type: Article

References (32)

1. Dagogo-Jack S, (2006) Primary prevention of type-2 diabetes in developing countries. J Natl Med Assoc 98: 415-9.
2. Bethesda: Atlas of End-Stage Renal Disease in the United States, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, in U.S. Renal Data System, USRDS 2003 Annual Data Report.
3. Menini S, Iacobini C, Oddi G, Ricci C, Simonelli P, et al. (2007) Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease. Diabetologia 50: 2591-9.
4. Reidy K, Susztak K, (2009) Epithelial-mesenchymal transition and podocyte loss in diabetic kidney disease. Am J Kidney Dis 54: 590-3.
5. Yamaguchi Y, Iwano M, Suzuki D, Nakatani K, Kimura K, et al. (2009) Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy. Am J Kidney Dis 54: 653-64.
6. Miyauchi M, Toyoda M, Kobayashi K, Abe M, Kobayashi T, et al. (2009) Hypertrophy and loss of podocytes in diabetic nephropathy. Intern Med 48: 1615-20.
7. Camici M, (2007) Urinary detection of podocyte injury. Biomed Pharmacother 61: 245-9.
8. Nielsen JS, McNagny KM, (2009) The role of podocalyxin in health and disease. J Am Soc Nephrol 20: 1669-76.
9. Ihalmo P, Wessman M, Kaunisto MA, Kilpikari R, Parkkonen M, et al. (2008) Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. Diabetologia 51: 86-90.
10. Menne J, Meier M, Park JK, Boehne M, Kirsch T, et al. (2006) Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo. Kidney Int 70: 1456-62.
11. Liss B, (2002) Improved quantitative real-time RT-PCR for expression profiling of individual cells. Nucleic Acids Res 30: e89.
12. Mas VR, Maluf DG, Archer KJ, Yanek K, King A, et al. (2005) Study of mRNA growth factors in urinary cells of kidney transplant recipients as predictors of chronic allograft nephropathy. Transplantation 80: 1686-91.
13. Wang G, Lai FM, Tam LS, Li KM, Lai KB, et al. (2007) Messenger RNA expression of podocyte-associated molecules in urinary sediment of patients with lupus nephritis. J Rheumatol 34: 2358-64.
14. Wang G, Lai FM, Lai KB, Chow KM, Kwan CH, et al. (2008) Urinary mRNA expression of ACE and ACE2 in human type 2 diabetic nephropathy. Diabetologia 51: 1062-7.
15. Wang G, Lai FM, Lai KB, Chow KM, Kwan BC, et al. (2010) Intra-renal and urinary mRNA expression of podocyte-associated molecules for the estimation of glomerular podocyte loss. Ren Fail 32: 372-9.
16. Steffes MW, Schmidt D, McCrery R, Basgen JM, (2001) Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int 59: 2104-13.
17. Susztak K, Raff AC, Schiffer M, Bottinger EP, (2006) Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55: 225-33.
18. Dai HY, Zheng M, Tang RN, Ni J, Ma KL, et al. (2011) The effects of angiotensin receptor blocker on phenotypic alterations of podocytes in early diabetic nephropathy. Am J Med Sci 341 (3): 207-14.
19. Teiken JM, Audettey JL, Laturnus DI, Zheng S, Epstein PN, et al. (2008) Podocyte loss in aging OVE26 diabetic mice. Anat Rec (Hoboken) 291: 114-21.
20. White KE, Bilous RW, (2004) Structural alterations to the podocyte are related to proteinuria in type 2 diabetic patients. Nephrol Dial Transplant 19: 1437-40.
21. Nakamura T, Ushiyama C, Suzuki S, Hara M, Shimada N, et al. (2000) Urinary excretion of podocytes in patients with diabetic nephropathy. Nephrol Dial Transplant 15: 1379-83.
22. Li B, Hartono C, Ding R, Sharma VK, Ramaswamy R, et al. (2001) Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med 344: 947-54.
23. Muthukumar T, Dadhania D, Ding R, Snopkowski C, Naqvi R, et al. (2005) Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 353: 2342-51.
24. Schmid H, Henger A, Cohen CD, Frach K, Grone HJ, et al. (2003) Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases. J Am Soc Nephrol 14: 2958-66.
25. Chan RW, Lai FM, Li EK, Tam LS, Chow KM, et al. (2006) The effect of immunosuppressive therapy on the messenger RNA expression of target genes in the urinary sediment of patients with active lupus nephritis. Nephrol Dial Transplant 21: 1534-40.
26. Chan RW, Lai FM, Li EK, Tam LS, Chow KM, et al. (2007) Expression of T-bet, a type 1 T-helper cell transcription factor, in the urinary sediment of lupus patients predicts disease flare. Rheumatology (Oxford) 46: 44-8.
27. Wang G, Lai FM, Lai KB, Chow KM, Li KT, et al. (2007) Messenger RNA expression of podocyte-associated molecules in the urinary sediment of patients with diabetic nephropathy. Nephron Clin Pract 106: c169-79.
28. Su J, Li SJ, Chen ZH, Zeng CH, Zhou H, et al. (2010) Evaluation of podocyte lesion in patients with diabetic nephropathy: Wilms' tumor-1 protein used as a podocyte marker. Diabetes Res Clin Pract 87: 167-75.
29. Sato Y, Wharram BL, Lee SK, Wickman L, Goyal M, et al. (2009) Urine podocyte mRNAs mark progression of renal disease. J Am Soc Nephrol 20: 1041-52.
30. Ichikawa I, Ma J, Motojima M, Matsusaka T, (2005) Podocyte damage damages podocytes: autonomous vicious cycle that drives local spread of glomerular sclerosis. Curr Opin Nephrol Hypertens 14: 205-10.
31. (2007) KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease. Am J Kidney Dis 49: S12-154.
32. Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, et al. (2006) Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 17: 2937-44.