Architecture and properties of bi-modal porous scaffolds for bone regeneration prepared via supercritical CO 2 foaming and porogen leaching combined process

Journal of Supercritical Fluids

Volumn 67, Issue , 2012, Pages 114-122

  Salerno, A ^a,b   Zeppetelli, S ^b   Di Maio, E ^c   Iannace, S ^b   Netti, P A ^a,c  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Hydroxyapatite; Poly( caprolactone); Scaffold; Supercritical CO 2 foaming; Zein

Indexed keywords

BIOLOGICAL CHARACTERIZATION; BONE CELL ADHESION; BONE REGENERATION; BONE TISSUE ENGINEERING; CAPROLACTONE; COMPOSITE SCAFFOLDS; DEPRESSURIZATIONS; FOAMING PROCESS; FOAMING TEMPERATURE; GREEN PROCESS; IN-VITRO; MACRO-POROSITY; MULTIPHASE COMPOSITES; POROGEN LEACHING; POROUS SCAFFOLD; STATIC COMPRESSION; SUPERCRITICAL CO;

BIOCOMPATIBILITY; BLOWING AGENTS; BONE; CARBON DIOXIDE; CELL ADHESION; CELL CULTURE; CHARACTERIZATION; COMPRESSION TESTING; HYDROXYAPATITE; LEACHING; PLASTICIZERS; PORE STRUCTURE; REINFORCED PLASTICS; SCAFFOLDS; ZEIN;

SCAFFOLDS (BIOLOGY);

EID: 84862092686     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2012.03.016     Document Type: Article

References (29)

1. D.W. Hutmacher Scaffolds in tissue engineering bone and cartilage Biomaterials 21 2000 2529 2543
2. J.R. Porter, T.T. Ruckh, and K.C. Popat Bone tissue engineering: a review in bone biomimetics and drug delivery strategies Biotechnology Progress 25 2009 1539 1560
3. S. Yang, K. Leong, Z. Du, and C. Chua The design of scaffolds for use in tissue engineering. Part I. Traditional factors Tissue Engineering 7 2001 679 689
4. V. Guarino, F. Causa, A. Salerno, L. Ambrosio, and P.A. Netti Design and manufacture of microporous polymeric materials with hierarchal complex structure for biomedical application Materials Science & Technology 24 2008 1111 1117
5. M.M.C.G. Silva, L.A. Cyster, J.J.A. Barry, X.B. Yang, R.O.C. Oreffo, D.M. Grant, C.A. Scotchford, S.M. Howdle, K.M. Shakesheff, and F.R.A. Rose The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds Biomaterials 35 2006 5909 5917
6. A. Salerno, D. Guarnieri, M. Iannone, S. Zeppetelli, and P.A. Netti Effect of micro- and macroporosity of bone tissue three-dimensional-poly(e- caprolactone) scaffold on human mesenchymal stem cells invasion, proliferation, and differentiation in vitro Tissue Engineering: Part A 16 2010 2661 2673
7. D.L. Elbert Bottom-up tissue engineering Current Opinion in Biotechnology 22 2011 674 680
8. 2 foaming Macromolecular Rapid Communications 32 2011 1150 1156
9. V.E. Santo, A.R.C. Duarte, M.E. Gomes, J.F. Mano, and R.L. Reis Hybrid 3D structure of poly(d,l-lactic acid) loaded with chitosan/chondroitin sulfate nanoparticles to be used as carriers for biomacromolecules in tissue engineering J. Supercritical Fluids 54 2010 320 327
10. 2 injection system for the production of polymer/mammalian cell composites J. Supercritical Fluids 43 2008 535 541
11. E. Kiran Foaming strategies for bioabsorbable polymers in supercritical fluid mixtures. Part II. Foaming of poly(ε-caprolactone-co-lactide) in carbon dioxide and carbon dioxide + acetone fluid mixtures and formation of tubular foams via solution extrusion J. Supercritical Fluids 54 2010 308 319
12. A. Salerno, M. Oliviero, E. Di Maio, P.A. Netti, C. Rofani, A. Colosimo, V. Guida, B. Dallapiccola, P. Palma, E. Procaccini, A.C. Berardi, F. Velardi, A. Teti, and S. Iannace Design of novel three-phase PCL/TZ-HA biomaterials for use in bone regeneration applications J. Materials Science Materials in Medicine 21 2010 2569 2581
13. A. Salerno, S. Zeppetelli, M. Oliviero, E. Battista, E. Di Maio, S. Iannace, P.A. Netti, Micro-structure, degradation and in vitro MG63 cells interaction with a novel biodegradable composite made of poly(ε- caprolactone), thermoplastic zein and hydroxyapatite for bone tissue engineering, J. Bioactive and Compatible Polymers (2012), in press, http://dx.doi.org/10.1177/0883911512442564.
14. R. Murugan, and S. Ramakrishna Development of nanocomposites for bone grafting Composites Science and Technology 65 2005 2385 2406
15. A.R. Boccaccini, M. Erol, W.J. Stark, D. Mohn, Z. Hong, and J.F. Mano Polymer/bioactive glass nanocomposites for biomedical applications: a review Composites Science and Technology 70 2010 1764 1776
16. J. Dong, Q. Sun, and J. Wang Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility Biomaterials 25 2004 4691 4697
17. Z. Qu, H. Wang, T. Tang, X. Zhang, J. Wang, and K. Dai Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation Acta Biomaterialia 4 2008 1360 1368
18. J. Tu, H. Wang, H. Li, K. Dai, J. Wang, and X. Zhang The in vivo bone formation by mesenchymal stem cells in zein scaffolds Biomaterials 30 2009 4369 4376
19. R.B. Yoganathana, R. Mammucari, and N.R. Foster Dense gas processing of polymers Polymer Reviews 50 2010 144 177
20. Z. Lian, S.A. Epstein, C.W. Blenk, and A.D. Shine Carbon dioxide-induced melting point depression of biodegradable semicrystalline polymers J. Supercritical Fluids 39 2006 107 117
21. A. Salerno, M. Oliviero, E. Di Maio, S. Iannace, and P.A. Netti Design and preparation of μ-bimodal porous scaffold for tissue engineering J. Applied Polymer Science 106 2007 3335 3342
22. 2 Acta Biomaterialia 6 2010 1055 1060
23. A. Salerno, M. Oliviero, E. Di Maio, and S. Iannace Thermoplastic foams from gelatin and zein International Polymer Processing 5 2007 1 9
24. I. Gerçek Beşkardeş, and M. Gümüş derelioglu Biomimetic apatite-coated PCL scaffolds: effect of surface nanotopography on cellular functions J. Bioactive and Compatible Polymers 24 2009 507
25. S.J. Hollister Porous scaffold design for tissue engineering Nature Materials 4 2005 518 524
26. C.R. Kothapalli, M.T. Shaw, and M. Wei Biodegradable HA-PLA 3D porous scaffolds: Effect of nano-sized filled content on scaffold properties Acta Biomaterialia 1 2005 653 662
27. J.C. Meredith, J. Sormana, B.G. Keselowsky, A.J. García, A. Tona, A. Karim, and E.J. Amis Combinatorial characterization of cell interactions with polymer surfaces J. Biomedical Materials Research 66A 2003 483 490
28. T.P. Kunzler, T. Drobek, M. Schuler, and N.D. Spencer Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients Biomaterials 13 2007 2175 2182
29. T. Yoshida, Y. Koyama, M. Kikuchi, and K. Takakuda Osteogenic activity of MG63 cells on bone-like hydroxyapatite/collagen nanocomposite sponges J. Materials Science Materials in Medicine 21 2010 1263 1272