Development of continuous anti-solvent/cooling crystallization process using cascaded mixed suspension, mixed product removal crystallizers

Organic Process Research and Development

Volumn 16, Issue 5, 2012, Pages 915-924

  Zhang, Haitao ^a   Quon, Justin ^a   Alvarez, Alejandro J ^b   Evans, James ^a   Myerson, Allan S ^a   Trout, Bernhardt ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-SOLVENTS; CONTINUOUS CRYSTALLIZATION; CRYSTAL PROPERTIES; CRYSTAL PURITY; CRYSTALLIZATION PROCESS; EQUILIBRIUM DISTRIBUTION COEFFICIENT; MIXED SUSPENSIONS; NUCLEATION KINETICS; OPERATING TEMPERATURE; PHARMACEUTICAL INTERMEDIATES; POPULATION BALANCE MODELS; RESIDENCE TIME;

PARAMETER ESTIMATION;

GROWTH KINETICS;

EID: 84862083136     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op2002886     Document Type: Article

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