Kinetics estimation and single and multi-objective optimization of a seeded, anti-solvent, isothermal batch crystallizer

Industrial and Engineering Chemistry Research

Volumn 47, Issue 5, 2008, Pages 1586-1595

  Trifkovic, M ^a   Sheikhzadeh, M ^a   Rohani, S ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLIZERS; DRUG PRODUCTS; OPTIMIZATION; SOLVENTS;

GROWTH KINETIC PARAMETERS; NONLINEAR REGRESSION; PARACETAMOL;

REACTION KINETICS;

CRYSTALLIZERS; DRUG PRODUCTS; OPTIMIZATION; REACTION KINETICS; SOLVENTS;

EID: 41749115768     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie071125g     Document Type: Article

References (19)

1. Togkalidou, T.; Fujiwara, M.; Patel, S.; Braatz, R. D. Solute Concentration Prediction Using Chemometrics and ATR-FTIR Spectros-copy. J. Cryst. Growth 2001, 231, 534-543.
2. Mougin, P.; Wilkinson, D. In Situ Measurement of Particle Size during the Crystallization of L-Glutamic Acid under Two Polymorphic Forms: Influence of Crystal Habit on Ultrasonic Attenuation Measurement. Cryst. Growth Des. 2002, 2, 227-234.
3. Higgins, J. P.; Arrivo, S. P.; Tharau, G.; Green, R. L.; Bowen, L.; Lange, A.; Templeton, A. C.; Thomas, D. L.; Reed, R. A. Spectroscopic Approach for On-Line Monitoring of Particle Size during Processing of Pharmaceutical Nanoparticles. Anal. Chem. 2003, 75, 1777-1785.
4. Tadayyon, A.; Rohani, S. Determination of PSD by ParTec 100: Modeling and Experimental Results. Part. Part. Syst. Charact. 1998, 15, 127-135.
5. O'Sullivan, B.; Glennon, B. Application of in Situ FBRM and ATR-FTIR to the Monitoring of the Polymorphic Transformation of D-Manitol. Org. Process Res. Dev. 2005, 9 (6), 884-889.
6. Togkalidou, T.; Tung, H.; Sun, Y.; Andrews, A. T.; Braatz, R. D. Parameter Estimation and Optimization of a Loosely Bound Aggregating Pharmaceutical Crystallization Using in Situ Infrared and Laser Backscattering Measurements. Ind. Eng. Chem. Res. 2004, 43, 6168-6181.
7. Zhou, G. X.; Fujiwara, M.; Woo, X. W.; Rusli, E.; Tung, H.; Starbuck, C.; Davidson, O.; Ge, Z.; Braatz, R. D. Direct Design of Pharmaceutical Antisolvent Crystallization through Concentration Control. Cryst. Growth Des. 2006, 6, 892-898.
8. Sheikhzadeh, M., Trifkovic M., Rohani S. Adaptive MIMO Neuro-Fuzzy Logic Control of Seeded and Unseeded Anti-Solvent Semi-Batch Crystallizer. Chem. Eng. Sci. Accepted, 2007.
9. Jones, A. G. Optimal Operation of a Batch Cooling Crystallizer. Chem. Eng. Sci. 1974, 29, 1075-1087.
10. Rohani, S.; Bourne, J. R. A Simplified Approach to the Operation of a Batch Crystallizer. Can. J. Chem. Eng. 1990, 68, 795-806.
11. Miller, S. M.; Rawlings, J. B. Model Identification and Control Strategies for Batch Cooling Crystallizer. AIChE J. 1994, 40, 1312-1327.
12. Hojjati, H.; Rohani, S. Measurement and Prediction of Solubility of Paracetamol in Water-Isopropanol Mixture. Part 1: Measurement. Org. Process Res. Dev. 2006, 10(6), 1101-1109.
13. Sheikhzadeh, M.; Trifkovic M.; Rohani S. Fuzzy Logic and Rigid Control of a Seeded Semi-Batch, Anti Solvent, Isothermal Crystallizer. Chem. Eng. Sci. Accepted, 2007.
14. Mersmann, Ed.A. Crystallization Technology Handbook; Marcell Dekker Inc.: New York, 1995.
15. Mersmann, A.; Braun, B.; Loffelmann, M. Prediction of Crystallization Coefficients of the Population Balance. Chem. Eng. Sci. 2002, 57, 4267-4275.
16. Randolph, A. D., Larson M. A. Theory of Particulate Processes; Academic Press: New York, 1988.
17. Hu, Q.; Rohani S.; Jutan A. Modeling and Optimization of Batch Seeded Cooling Crystallizers. Comput. Chem. Eng. 2005, 911-918.
18. Hu, Q.; Rohani, S.; Wang, D. X.; Jutan, A. Optimal Control of a Seeded Batch Crystallizer. Powder Technol. 2005, 156, 170-176.
19. Hu, Q.; Rohani, S.; Jutan, A. New Numerical Method for Solving the Dynamic Population Balance. AIChE J. 2005, 51, 3000-3006.