Development and scale-up of a continuous, high-pressure, asymmetric hydrogenation reaction, workup, and isolation

Organic Process Research and Development

Volumn 16, Issue 5, 2012, Pages 1017-1038

  Johnson, Martin D ^a   May, Scott A ^a   Calvin, Joel R ^a   Remacle, Jacob ^a,c   Stout, James R ^a,b,d   Diseroad, William D ^a   Zaborenko, Nikolay ^a   Haeberle, Brian D ^a   Sun, Wei Ming ^a   Miller, Michael T ^a   Brennan, John ^a  

^a ELI LILLY AND COMPANY   (United States)

^b DandM Continuous Solutions   (United States)

^c DOW CORNING CORPORATION   (United States)

^d D and M Continuous Solutions   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A PLANTS; AQUEOUS EXTRACTION; ASYMMETRIC HYDROGENATION; CONTINUOUS CRYSTALLIZATION; CONTINUOUS FLOWS; CONTINUOUS PROCESS; CONTINUOUS REACTIONS; FLOW REACTORS; FUME HOODS; HYDROGENATION REACTIONS; HYDROGENATION REACTORS; IMPURITY CONTROL; KINETIC REGIME; PILOT SCALE; PLUG FLOW; RESIDENCE TIME; RUNNING-IN; SCALE-UP; STEADY STATE; VESSEL SIZE; WET-END;

BATCH DATA PROCESSING; FUME CONTROL; HYDROGEN; LABORATORIES; SOLVENT EXTRACTION; THROUGHPUT;

HYDROGENATION;

EID: 84862063361     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op200362h     Document Type: Article

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