Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 10, 2012, Pages

  Reszka, Krzysztof J ^a,d   Xiong, Ye ^a   Sallans, Larry ^b   Pasula, Rajamouli ^a   Olakanmi, Oyebode ^a   Hassett, Daniel J ^c,d   Britigan, Bradley E ^a,e,f,g  

^a Department of Internal Medicine ^*  (United States)

^b Departments of Chemistry   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d Departments of Research Service   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^g VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

Author keywords

1 hydroxyphenazine; Lactoperoxidase; Myeloperoxidase; Nitration; Oxidation; Phenazines

Indexed keywords

CYTOTOXIN; HYDROGEN PEROXIDE; LACTOPEROXIDASE; MYELOPEROXIDASE; NITRIC OXIDE; NITRITE; PEROXIDASE; PYOCYANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SODIUM NITRITE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; ELECTRON SPIN RESONANCE; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFLAMMATION; LUNG INJURY; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; SPIN TRAPPING; STAPHYLOCOCCUS AUREUS;

ANIMALS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; HYDROGEN PEROXIDE; INSTILLATION, DRUG; LACTOPEROXIDASE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; PEROXIDASE; PEROXIDASES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; PYOCYANINE; RESPIRATORY MUCOSA; SODIUM NITRITE; SUPEROXIDES; TRACHEA;

EID: 84862061460     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00172.2011     Document Type: Article

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