Mitochondria-derived reactive intermediate species mediate asbestos-induced genotoxicity and oxidative stress-responsive signaling pathways

Environmental Health Perspectives

Volumn 120, Issue 6, 2012, Pages 840-847

  Huang, Sarah X L ^a   Partridge, Michael A ^b,c   Ghandhi, Shanaz A ^b   Davidson, Mercy M ^b   Amundson, Sally A ^b   Hei, Tom K ^a,b  

^a Columbia University ^*  (United States)

^b Regeneron Pharmaceuticals ^*  (United States)

^c REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

Asbestos; DNA oxidative damage; Genotoxicity; Mitochondria; Oxidative stress responsive signaling pathways; Reactive oxygen species

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ADAPTOR PROTEIN; ASBESTOS FIBER; CD34 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR7; CHRYSOTILE; COLONY STIMULATING FACTOR; CROCIDOLITE; FAS ANTIGEN; GROWTH FACTOR; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 6; INTERLEUKIN 8; MELANOCORTIN 2 RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN E RECEPTOR 2; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; VASCULOTROPIN;

ARTICLE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; INFLAMMATORY CELL; MICRONUCLEUS; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ASBESTOS; DEOXYGUANOSINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HUMANS; MICRONUCLEUS TESTS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RESPIRATORY SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 84862023012     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104287     Document Type: Article

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