One study, two paths: The challenge of dual-use research

Environmental Health Perspectives

Volumn 120, Issue 6, 2012, Pages

  Holtcamp, Wendee ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AVIAN INFLUENZA VIRUS; DUAL USE RESEARCH; GOVERNMENT REGULATION; HEALTH CARE POLICY; HUMAN; INFLUENZA VIRUS A H5N1; MEDICAL RESEARCH; NONHUMAN; NOTE; PRIORITY JOURNAL; VIRUS INFECTIVITY; VIRUS TRANSMISSION; DISEASE TRANSMISSION; GOVERNMENT; INFLUENZA; ORGANIZATION AND MANAGEMENT; POLICY; RESEARCH; UNITED STATES; VIROLOGY;

BOTULINUM TOXIN;

BOTULINUM TOXINS; FEDERAL GOVERNMENT; GOVERNMENT REGULATION; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; PUBLIC POLICY; RESEARCH; SECURITY MEASURES; UNITED STATES;

EID: 84862013659     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.120-a238     Document Type: Note

References (27)

1. National Research Council. Biotechnology Research in an Age of Terrorism. Washington, DCNational Academies Press (2004). Available: http://www.nap.edu/catalog.php?record_id=10827 [accessed 7 May 2012].
2. OBA. United States Government Policy for Oversight of Life Sciences Dual Use Research of Concern [website]. Bethesda, MD: Office of Biotechnology Activities, Office of Science Policy, National Institutes of Health. Available: http://oba.od.nih.gov/oba/biosecurity/PDF/United_States_Government_Policy_for_Oversight_of_DURC_FINAL_version_032812.pdf [accessed 7 May 2012].
3. WHO. Public Health, Influenza Experts Agree H5N1 Research Critical, but Extend Delay [press release]. Geneva, Switzerland:World Health Organization (17 Feb 2012). Available: http://www.who.int/ediacentre/news/releases/2012/h5n1_research_20120217/en/index.html [accessed 7 May 2012].
4. Racaniello VR. Science should be in the public domain. mBio 3(1):e00004-12 (2012); http://dx.doi.org/10.1128/mBio.00004-12.
5. OSP. About NSABB [website]. Bethesda, MD: Office of Science Policy, National Institutes of Health. (2012). Available:http://oba.od.nih.gov/biosecurity/about_nsabb.html [accessed 7 May 2012].
6. AAAS. Statement by Science Editor-in-Chief Dr. Bruce Alberts Regarding Publication of H5N1 Avian Influenza Research [press release]. Washington, DC: American Association for the Advancement of Science (20 Dec 2011). Available:http://www.aaas.org/news/releases/2011/media/1220herfst_statement.pdf [accessed 7 May 2012].
7. Fouchier RAM, et al. Pause on avian flu transmission research. Science 335(6067):400-401 (2012); http://dx.doi.org/10.1126/science.335.6067.400.
8. Berg P. Asilomar and Recombinant DNA [website]. Stockholm, Sweden: Nobel Media (26 Aug 2004). Available: http://www.nobelprize.org/nobel_prizes/chemistry/laureates/1980/berg-article.html [accessed 7 May 2012].
9. Academy eBriefings: Dual Use Research: H5N1 Influenza Virus and Beyond. [website]. New York, NY: The New York Academy of Sciences (updated 24 Feb 2012). Available: http://www.nyas.org/Publications/EBriefings/Detail.aspx?cid=4cd6eec7-7bbf-4be8-b9d3-b458937c043d [accessed 7 May 2012].
10. Cohen J. WHO group: H5N1 papers should be published in full. Science 335(6071):899-900 (2012); http://dx.doi.org/10.1126/science.335.6071.899.
11. Imai M, et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature (2012); doi:10.1038/nature1083 [online 2 May 2012].
12. NSABB. Proposed Framework for the Oversight of Dual Use Life Sciences Research: Strategies for Minimizing the Potential Misuse of Research Information. A Report of the National Science Advisory Board for Biosecurity (NSABB). Washington, DC:National Science Advisory Board for Biosecurity (Jun 2007). Available: http://oba.od.nih.gov/biosecurity/pdf/Framework%20for%20transmittal%20 0807_Sept07.pdf [accessed 7 May 2012].
13. Selgelid MJ. Governance of dual-use research: an ethical dilemma. Bull WHO 87(9):720-723 (2009);http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739909/
14. Office of Classification Mission and Function [website]. Washington, DC: Office of Health, Safety, and Security, Department of Energy. Available: http://www.hss.doe.gov/classification/ [accessed 7 May 2012].
15. Moreno JD. Neuroethics: an agenda for neuroscience and society. Nat Reviews Neurosci 4(2):149-153 (2003); http://dx.doi.org/10.1038/nrn1031.
16. Wein LM, Liu Y. Analyzing a bioterror attack on the food supply: the case of botulinum toxin in milk. Proc Natl Acad Sci USA 102(28):9984-9989 (2005); http://dx.doi.org/10.1073/pnas.0408526102.
17. Re: The article "Analyzing a Bioterror Attack on the Food Supply: The Case of Botulinum Toxin in Milk" by Lawrence Wein and Yifan Liu. Letter from Stewart Simonson to Bruce Alberts. 27 May 2005. Available: http://www.fas.org/sgp/bush/hhs052705.pdf [accessed 7 May 2012].
18. Alberts B. Modeling attacks on the food supply. Proc Natl Acad Sci USA 102 (28):9737-9738 (2005); http://dx.doi.org/10.1073/pnas.0504944102.
19. Lilienfeld DE, Gallo, MA. 2,4-D, 2,4,5-T, and 2,3,7,8-TCDD: an overview. Epidemiol Rev 11(1):28-58 (1989); PMID: 2680561.
20. Suk JE, et al. Dual-use research and technological diffusion: reconsidering the bioterrorism threat spectrum. PLoS Pathog 7(1):e10 0125 3 (2011); http://dx.doi.org/10.1371/journal.ppat.1001253.
21. Shea DA. Balancing Scientific Publication and National Security Concerns: Issues for Congress. CRS Report for Congress. Washington, DC: Congressional Research Service (updated 2 Feb 2006). Available: http://www.fas.org/sgp/crs/secrecy/RL31695.pdf [accessed 7 May 2012].
22. Resnik DB. Can scientists regulate the publication of dual use research? Stud Ethics Law Technol 4:1 (2010); http://dx.doi.org/10.2202/1941-6008.1124.
23. Jackson RJ, et al. Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. J Virol 75(3):1205-1210 (20 01); http://dx.doi.org/10.1128/JVI.75.3.1205-1210.2001.
24. Stitt-Fischer MS. The National Institutes of Health Dual Use Screening Program: A Proposed Quality Control Mode [speech]. Presented at: Annual Biological Safety Association Conference, Denver, CO, 5 Oct 2010. Available: http://www.absaconference.org/pdf53/Session11-Stitt-Fischer.pdf [accessed 7 May 2012].
25. Morgan MC. Evaluation of a First-Tier Screening Program for Dual Use Research of Concern [speech]. Presented at: Annual Biological Safety Association Conference, Denver, CO, 5 Oct 2010. Available: http://www.absaconference.org/pdf53/Session11-Morgan.pdf [accessed 7 May 2012].
26. Resnik DB, et al. Dual-use review policies of biomedical research journals. Biosecur Bioterror 9(1):49-54 (2011); http://dx.doi.org/10.1089/bsp.2010.0067.
27. EHP. Instructions to Authors [website]. Research Triangle Park, NC: Environmental Health Perspectives, National Institute of Environmental Health Sciences (2012). Available: http://ehp03.niehs.nih.gov/static/instructions.action [accessed 7 May 2012].