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Volumn 19, Issue 6, 2012, Pages 613-621

Targeting S100A1 in heart failure

Author keywords

calcium; heart failure; S100A1; sarcoplasmic reticulum

Indexed keywords

ADENOVIRUS VECTOR; ALDOSTERONE ANTAGONIST; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM BINDING PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; METOPROLOL; PROTEIN S100A1; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; UNCLASSIFIED DRUG;

EID: 84862012200     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2012.8     Document Type: Review
Times cited : (37)

References (70)
  • 1
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2011 update: A report from the American Heart Association
    • Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM et al. Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation 2011; 123: e18-e209.
    • (2011) Circulation , vol.123
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3    Adams, R.J.4    Berry, J.D.5    Brown, T.M.6
  • 3
    • 65349121886 scopus 로고    scopus 로고
    • Genomics, transcriptional profiling, and heart failure
    • Review
    • Margulies KB, Bednarik DP, Dries DL. Genomics, transcriptional profiling, and heart failure. J Am Coll Cardiol 2009; 53: 1752-1759. Review.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1752-1759
    • Margulies, K.B.1    Bednarik, D.P.2    Dries, D.L.3
  • 4
    • 0037423881 scopus 로고    scopus 로고
    • Is depressed myocyte contractility centrally involved in heart failure?
    • DOI 10.1161/01.RES.0000060027.40275.A6
    • Houser SR, Margulies KB. Is depressed myocyte contractility centrally involved in heart failure? Circ Res 2003; 92: 350-358. (Pubitemid 36298194)
    • (2003) Circulation Research , vol.92 , Issue.4 , pp. 350-358
    • Houser, S.R.1    Margulies, K.B.2
  • 5
    • 0002537440 scopus 로고    scopus 로고
    • Cardiac hypertrophy: The good, the Bad, and the ugly
    • DOI 10.1146/annurev.physiol.65.092101.142243
    • Frey N, Olson EN. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 2003; 65: 45-79. (Pubitemid 38249147)
    • (2003) Annual Review of Physiology , vol.65 , pp. 45-79
    • Frey, N.1    Olson, E.N.2
  • 6
    • 53249090182 scopus 로고    scopus 로고
    • ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008 the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology
    • Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
    • Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 2008; 29: 2388-2442.
    • (2008) Eur Heart J , vol.29 , pp. 2388-2442
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3    McMurray, J.J.4    Ponikowski, P.5    Poole-Wilson, P.A.6
  • 7
    • 0037732862 scopus 로고    scopus 로고
    • Heart failure therapy at a crossroad: Are there limits to the neurohormonal model?
    • DOI 10.1016/S0735-1097(03)00245-6
    • Mehra MR, Uber PA, Francis GS. Heart failure therapy at a crossroad: are there limits to the neurohormonal model? J Am Coll Cardiol 2003; 41: 1606-1610. (Pubitemid 36543382)
    • (2003) Journal of the American College of Cardiology , vol.41 , Issue.9 , pp. 1606-1610
    • Mehra, M.R.1    Uber, P.A.2    Francis, G.S.3
  • 8
    • 48249116367 scopus 로고    scopus 로고
    • Gene therapy in heart failure
    • Vinge LE, Raake PW, Koch WJ. Gene therapy in heart failure. Circ Res 2008; 102: 1458-1470.
    • (2008) Circ Res , vol.102 , pp. 1458-1470
    • Vinge, L.E.1    Raake, P.W.2    Koch, W.J.3
  • 9
    • 43549098268 scopus 로고    scopus 로고
    • Calcium cycling and signaling in cardiac myocytes
    • DOI 10.1146/annurev.physiol.70.113006.100455
    • Bers DM. Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol 2008; 70: 23-49. (Pubitemid 351738170)
    • (2008) Annual Review of Physiology , vol.70 , pp. 23-49
    • Bers, D.M.1
  • 11
    • 79961032369 scopus 로고    scopus 로고
    • Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure
    • Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B et al. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation 2011; 124: 304-313.
    • (2011) Circulation , vol.124 , pp. 304-313
    • Jessup, M.1    Greenberg, B.2    Mancini, D.3    Cappola, T.4    Pauly, D.F.5    Jaski, B.6
  • 12
    • 0032983595 scopus 로고    scopus 로고
    • Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
    • DOI 10.1016/S0167-4889(99)00058-0, PII S0167488999000580
    • Donato R. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta 1999; 1450: 191-231. (Pubitemid 29295473)
    • (1999) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1450 , Issue.3 , pp. 191-231
    • Donato, R.1
  • 13
    • 4444371768 scopus 로고    scopus 로고
    • S100 proteins in mouse and man: From evolution to function and pathology (including an update of the nomenclature)
    • DOI 10.1016/j.bbrc.2004.07.096, PII S0006291X04015475
    • Marenholz I, Heizmann CW, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun 2004; 322: 1111-1122. (Pubitemid 39164640)
    • (2004) Biochemical and Biophysical Research Communications , vol.322 , Issue.4 , pp. 1111-1122
    • Marenholz, I.1    Heizmann, C.W.2    Fritz, G.3
  • 14
    • 0036580943 scopus 로고    scopus 로고
    • S100 proteins: Structure, functions and pathology
    • Heizmann CW, Fritz G, Schafer BW. S100 proteins: structure, functions and pathology. Front Biosci 2002; 7: d1356-d1368.
    • (2002) Front Biosci , vol.7
    • Heizmann, C.W.1    Fritz, G.2    Schafer, B.W.3
  • 16
    • 30644464166 scopus 로고    scopus 로고
    • S100-mediated signal transduction in the nervous system and neurological diseases
    • Zimmer DB, Chaplin J, Baldwin A, Rast M. S100-mediated signal transduction in the nervous system and neurological diseases. Cell Mol Biol (Noisy-le-grand) 2005; 51: 201-214. (Pubitemid 43086295)
    • (2005) Cellular and Molecular Biology , vol.51 , Issue.2 , pp. 201-214
    • Zimmer, D.B.1    Chaplin, J.2    Baldwin, A.3    Rast, M.4
  • 19
    • 0142229704 scopus 로고    scopus 로고
    • Intracellular and extracellular roles of S100 proteins
    • Donato R. Intracellular and extracellular roles of S100 proteins. Microsc Res Tech 2003; 60: 540-551.
    • (2003) Microsc Res Tech , vol.60 , pp. 540-551
    • Donato, R.1
  • 20
    • 33744782044 scopus 로고    scopus 로고
    • Calcium-dependent and -independent interactions of the S100 protein family
    • DOI 10.1042/BJ20060195
    • Santamaria-Kisiel L, Rintala-Dempsey AC, Shaw GS. Calcium-dependent and-independent interactions of the S100 protein family. Biochem J 2006; 396: 201-214. (Pubitemid 43837235)
    • (2006) Biochemical Journal , vol.396 , Issue.2 , pp. 201-214
    • Santamaria-Kisiel, L.1    Rintala-Dempsey, A.C.2    Shaw, G.S.3
  • 21
    • 0031658212 scopus 로고    scopus 로고
    • Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization
    • DOI 10.1016/S0143-4160(98)90081-1
    • Osterloh D, Ivanenkov VV, Gerke V. Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization. Cell Calcium 1998; 24: 137-151. (Pubitemid 28470431)
    • (1998) Cell Calcium , vol.24 , Issue.2 , pp. 137-151
    • Osterloh, D.1    Ivanenkov, V.V.2    Gerke, V.3
  • 22
    • 0242304100 scopus 로고    scopus 로고
    • Molecular mechanisms of S100-target protein interactions
    • Zimmer DB, Wright Sadosky P, Weber DJ. Molecular mechanisms of S100-target protein interactions. Microsc Res Tech 2003; 60: 552-559.
    • (2003) Microsc Res Tech , vol.60 , pp. 552-559
    • Zimmer, D.B.1    Wright Sadosky, P.2    Weber, D.J.3
  • 23
    • 18944390851 scopus 로고    scopus 로고
    • Affinity of S100A1 protein for calcium increases dramatically upon glutathionylation
    • DOI 10.1111/j.1742-4658.2005.04680.x
    • Goch G, Vdovenko S, Kozlowska H, Bierzynski A. Affinity of S100A1 protein for calcium increases dramatically upon glutathionylation. FEBS J 2005; 272: 2557-2565. (Pubitemid 40705075)
    • (2005) FEBS Journal , vol.272 , Issue.10 , pp. 2557-2565
    • Goch, G.1    Vdovenko, S.2    Kozlsowska, H.3    Bierzynski, A.4
  • 25
    • 10044223332 scopus 로고    scopus 로고
    • Redox modifications of the C-terminal cysteine residue cause structural changes in S100A1 and S100B proteins
    • DOI 10.1016/j.bbamcr.2004.10.002, PII S0167488904002526, 8th Symposium on Calcium
    • Zhukova L, Zhukov I, Bal W, Wyslouch-Cieszynska A. Redox modifications of the C-terminal cysteine residue cause structural changes in S100A1 and S100B proteins. Biochim Biophys Acta 2004; 1742: 191-201. (Pubitemid 39601780)
    • (2004) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1742 , Issue.1-3 , pp. 191-201
    • Zhukova, L.1    Zhukov, I.2    Bal, W.3    Wyslouch-Cieszynska, A.4
  • 27
    • 69249212388 scopus 로고    scopus 로고
    • S100A1 in cardiovascular health and disease: Closing the gap between basic science and clinical therapy
    • Kraus C, Rohde D, Weidenhammer C, Qiu G, Pleger ST, Voelkers M et al. S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy. J Mol Cell Cardiol 2009; 47: 445-455.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 445-455
    • Kraus, C.1    Rohde, D.2    Weidenhammer, C.3    Qiu, G.4    Pleger, S.T.5    Voelkers, M.6
  • 28
    • 77951668568 scopus 로고    scopus 로고
    • S100A1: A regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function
    • Volkers M, Rohde D, Goodman C, Most P. S100A1: a regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function. J Biomed Biotechnol 2010; 2010: 178614.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 178614
    • Volkers, M.1    Rohde, D.2    Goodman, C.3    Most, P.4
  • 29
    • 0022428087 scopus 로고
    • 0 (alphaalpha) protein is mainly located in the heart and striated muscles
    • DOI 10.1016/0304-4165(85)90196-5
    • Kato K, Kimura S. S100ao (alpha alpha) protein is mainly located in the heart and striated muscles. Biochim Biophys Acta 1985; 842: 146-150. (Pubitemid 15239658)
    • (1985) Biochimica et Biophysica Acta - General Subjects , vol.842 , Issue.2-3 , pp. 146-150
    • Kato, K.1    Kimura, S.2
  • 30
    • 0034695003 scopus 로고    scopus 로고
    • Transcriptional regulation of S100A1 and expression during mouse heart development
    • Kiewitz R, Lyons GE, Schafer BW, Heizmann CW. Transcriptional regulation of S100A1 and expression during mouse heart development. Biochim Biophys Acta 2000; 1498: 207-219.
    • (2000) Biochim Biophys Acta , vol.1498 , pp. 207-219
    • Kiewitz, R.1    Lyons, G.E.2    Schafer, B.W.3    Heizmann, C.W.4
  • 31
    • 0023818922 scopus 로고
    • 0 (alphaalpha) protein in cardiac muscle. Isolation from human cardiac muscle and ultrastructural localization
    • Haimoto H, Kato K. S100a0 (alpha alpha) protein in cardiac muscle. Isolation from human cardiac muscle and ultrastructural localization. Eur J Biochem 1988; 171: 409-415. (Pubitemid 18042907)
    • (1988) European Journal of Biochemistry , vol.171 , Issue.1-2 , pp. 409-415
    • Haimoto, H.1    Kato, K.2
  • 33
    • 0025943211 scopus 로고
    • Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues
    • Zimmer DB, Song W, Zimmer WE. Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues. Brain Res Bull 1991; 27: 157-162.
    • (1991) Brain Res Bull , vol.27 , pp. 157-162
    • Zimmer, D.B.1    Song, W.2    Zimmer, W.E.3
  • 34
    • 0022558435 scopus 로고
    • S100a(O) (alphaalpha) protein: Distribution in muscle tissues of various animals and purification from human pectoral muscle
    • Kato K, Kimura S, Haimoto H, Suzuki F. S100a0 (alpha alpha) protein: distribution in muscle tissues of various animals and purification from human pectoral muscle. J Neurochem 1986; 46: 1555-1560. (Pubitemid 16062560)
    • (1986) Journal of Neurochemistry , vol.46 , Issue.5 , pp. 1555-1560
    • Kato, K.1    Kimura, S.2    Haimoto, H.3    Suzuki, F.4
  • 37
    • 27944500736 scopus 로고    scopus 로고
    • Co-expression/co-location of S100 proteins (S100B, S100A1 and S100A2) and protein kinase C (PKC-beta, -eta and -zeta) in a rat model of cerebral basilar artery vasospasm
    • DOI 10.1111/j.1365-2990.2005.00682.x
    • Lefranc F, Decaestecker C, Brotchi J, Heizmann CW, Dewitte O, Kiss R et al. Co-expression/co-location of S100 proteins (S100B, S100A1 and S100A2) and protein kinase C (PKC-beta,-eta and-zeta) in a rat model of cerebral basilar artery vasospasm. Neuropathol Appl Neurobiol 2005; 31: 649-660. (Pubitemid 41668375)
    • (2005) Neuropathology and Applied Neurobiology , vol.31 , Issue.6 , pp. 649-660
    • Lefranc, F.1    Decaestecker, C.2    Brotchi, J.3    Heizmann, C.W.4    Dewitte, O.5    Kiss, R.6    Mijatovic, T.7
  • 40
    • 27644548655 scopus 로고    scopus 로고
    • S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes
    • DOI 10.1016/j.yjmcc.2005.06.018, PII S0022282805002166
    • Kettlewell S, Most P, Currie S, Koch WJ, Smith GL. S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular cardiomyocytes. J Mol Cell Cardiol 2005; 39: 900-910. (Pubitemid 41572323)
    • (2005) Journal of Molecular and Cellular Cardiology , vol.39 , Issue.6 , pp. 900-910
    • Kettlewell, S.1    Most, P.2    Currie, S.3    Koch, W.J.4    Smith, G.L.5
  • 48
    • 0037266936 scopus 로고    scopus 로고
    • Understanding ATP synthesis: Structure and mechanism of the F1-ATPase (Review)
    • DOI 10.1080/09687680307078
    • Leyva JA, Bianchet MA, Amzel LM. Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review). Mol Membr Biol 2003; 20: 27-33. (Pubitemid 36460643)
    • (2003) Molecular Membrane Biology , vol.20 , Issue.1 , pp. 27-33
    • Leyva, J.A.1    Bianchet, M.A.2    Amzel, L.M.3
  • 49
    • 0036773295 scopus 로고    scopus 로고
    • Cardiac energy metabolism homeostasis: Role of cytosolic calcium
    • DOI 10.1016/S0022-2828(02)92082-1
    • Balaban RS. Cardiac energy metabolism homeostasis: role of cytosolic calcium. J Mol Cell Cardiol 2002; 34: 1259-1271. (Pubitemid 35244399)
    • (2002) Journal of Molecular and Cellular Cardiology , vol.34 , Issue.10 , pp. 1259-1271
    • Balaban, R.S.1
  • 51
    • 77952490479 scopus 로고    scopus 로고
    • Titin-isoform dependence of titin-actin interaction and its regulation by S100A1/Ca2+ in skinned myocardium
    • Fukushima H, Chung CS, Granzier H. Titin-isoform dependence of titin-actin interaction and its regulation by S100A1/Ca2+ in skinned myocardium. J Biomed Biotechnol 2010; 2010: 727239.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 727239
    • Fukushima, H.1    Chung, C.S.2    Granzier, H.3
  • 53
    • 33750061609 scopus 로고    scopus 로고
    • Cardiac titin: Structure, functions and role in disease
    • DOI 10.1016/j.cca.2006.06.035, PII S0009898106004086
    • LeWinter MM, Wu Y, Labeit S, Granzier H. Cardiac titin: structure, functions and role in disease. Clin Chim Acta 2007; 375: 1-9. (Pubitemid 44584235)
    • (2007) Clinica Chimica Acta , vol.375 , Issue.1-2 , pp. 1-9
    • Lewinter, M.M.1    Wu, Y.2    Labeit, S.3    Granzier, H.4
  • 54
    • 0036278824 scopus 로고    scopus 로고
    • The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes
    • Remppis A, Most P, Loffler E, Ehlermann P, Bernotat J, Pleger S et al. The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes. Basic Res Cardiol 2002; 97 (Suppl 1): I56-I62.
    • (2002) Basic Res Cardiol , vol.97 , Issue.SUPPL. 1
    • Remppis, A.1    Most, P.2    Loffler, E.3    Ehlermann, P.4    Bernotat, J.5    Pleger, S.6
  • 55
    • 34548781421 scopus 로고    scopus 로고
    • Immunocytochemical localization of S100A1 in mitochondria on cryosections of the rat heart
    • Brezova A, Heizmann CW, Uhrik B. Immunocytochemical localization of S100A1 in mitochondria on cryosections of the rat heart. Gen Physiol Biophys 2007; 26: 143-149. (Pubitemid 47422813)
    • (2007) General Physiology and Biophysics , vol.26 , Issue.2 , pp. 143-149
    • Brezova, A.1    Heizmann, C.W.2    Uhrik, B.3
  • 57
    • 84860390373 scopus 로고    scopus 로고
    • S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes
    • Brinks H, Rohde D, Voelkers M, Qiu G, Pleger ST, Herzog N et al. S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes. J Am Coll Cardiol 2011; 58: 966-973.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 966-973
    • Brinks, H.1    Rohde, D.2    Voelkers, M.3    Qiu, G.4    Pleger, S.T.5    Herzog, N.6
  • 61
    • 69249230113 scopus 로고    scopus 로고
    • Retroinfusionfacilitated inotropic AAV9-S100A1 gene therapy restores global cardiac function in a clinically relevant pig heart failure model
    • Pleger STSC, Kziencek J, Mueller O, Bekeredjian R, Remppis A et al. Retroinfusionfacilitated inotropic AAV9-S100A1 gene therapy restores global cardiac function in a clinically relevant pig heart failure model. Circulation 2008; 118: S792.
    • (2008) Circulation , vol.118
    • Stsc, P.1    Kziencek, J.2    Mueller, O.3    Bekeredjian, R.4    Remppis, A.5
  • 64
    • 0032126258 scopus 로고    scopus 로고
    • Animal models of human cardiovascular disease, heart failure and hypertrophy
    • DOI 10.1016/S0008-6363(98)00110-2, PII S0008636398001102
    • Hasenfuss G. Animal models of human cardiovascular disease, heart failure and hypertrophy. Cardiovasc Res 1998; 39: 60-76. (Pubitemid 28322380)
    • (1998) Cardiovascular Research , vol.39 , Issue.1 , pp. 60-76
    • Hasenfuss, G.1
  • 66
    • 79960696509 scopus 로고    scopus 로고
    • Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model
    • Pleger ST, Shan C, Ksienzyk J, Bekeredjian R, Boekstegers P, Hinkel R et al. Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model. Sci Transl Med 2011; 3: 92ra64.
    • (2011) Sci Transl Med , vol.3
    • Pleger, S.T.1    Shan, C.2    Ksienzyk, J.3    Bekeredjian, R.4    Boekstegers, P.5    Hinkel, R.6
  • 67
    • 84860420158 scopus 로고    scopus 로고
    • S100A1: Another step toward therapeutic development for heart failure
    • Belmonte SL, Margulies KB, Blaxall BC. S100A1: another step toward therapeutic development for heart failure. J Am Coll Cardiol 2011; 58: 974-976.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 974-976
    • Belmonte, S.L.1    Margulies, K.B.2    Blaxall, B.C.3
  • 69
    • 79952299939 scopus 로고    scopus 로고
    • Rescuing the failing heart by targeted gene transfer
    • Kawase Y, Ladage D, Hajjar RJ. Rescuing the failing heart by targeted gene transfer. J Am Coll Cardiol 2011; 57: 1169-1180.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 1169-1180
    • Kawase, Y.1    Ladage, D.2    Hajjar, R.J.3
  • 70
    • 62649133817 scopus 로고    scopus 로고
    • Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial
    • Jaski BE, Jessup ML, Mancini DM, Cappola TP, Pauly DF, Greenberg B et al. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial. J Card Fail 2009; 15: 171-181.
    • (2009) J Card Fail , vol.15 , pp. 171-181
    • Jaski, B.E.1    Jessup, M.L.2    Mancini, D.M.3    Cappola, T.P.4    Pauly, D.F.5    Greenberg, B.6


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