Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Krajewski, Stefanie ^a   Kurz, Julia ^a   Geisler, Tobias ^a   Peter, Karlheinz ^b   Wendel, Hans Peter ^a   Straub, Andreas ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 MESAMP; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; 9 (1 ANILINOETHYL) 7 METHYL 2 MORPHOLINOPYRIDO[1,2 A]PYRIMIDIN 4 ONE; ANTITHROMBOCYTIC AGENT; CD11B ANTIGEN; CELL MARKER; FIBRINOGEN RECEPTOR; PADGEM PROTEIN; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOINOSITIDE 3 KINASE P110BETA; PROPYLENE GLYCOL; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; THROMBIN RECEPTOR; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; ADENOSINE DIPHOSPHATE; DRUG DERIVATIVE; MORPHOLINE DERIVATIVE; N(6) METHYL 2' DEOXYADENOSINE 3',5' DIPHOSPHATE; N(6)-METHYL-2'-DEOXYADENOSINE 3',5'-DIPHOSPHATE; PIK3CB PROTEIN, HUMAN; PURINERGIC P2 RECEPTOR ANTAGONIST; PYRIMIDINONE DERIVATIVE;

ARTICLE; CELL INTERACTION; CELL LOSS; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; EXTRACORPOREAL CIRCULATION; FLOW CYTOMETRY; GRANULOCYTE; HUMAN; HUMAN CELL; HYPOTHERMIA; LEUKOCYTE ACTIVATION; MONOTHERAPY; PLATELET MICROPARTICLE; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR BLOCKING; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE COUNT; UPREGULATION; ANALYSIS OF VARIANCE; BIOLOGICAL MODEL; DRUG ANTAGONISM; HEART SURGERY; IN VITRO STUDY; INDUCED HYPOTHERMIA; LEUKOCYTE; METABOLISM; METHODOLOGY; PHYSIOLOGY;

ADENOSINE DIPHOSPHATE; ANALYSIS OF VARIANCE; CARDIAC SURGICAL PROCEDURES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACORPOREAL CIRCULATION; FLOW CYTOMETRY; HUMANS; HYPOTHERMIA, INDUCED; LEUKOCYTES; MODELS, BIOLOGICAL; MORPHOLINES; P-SELECTIN; PHOSPHATIDYLINOSITOL 3-KINASES; PLATELET ACTIVATION; PLATELET COUNT; PURINERGIC P2 RECEPTOR ANTAGONISTS; PYRIMIDINONES;

EID: 84862005637     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038455     Document Type: Article

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