Platelet anaesthesia during extracorporeal circulation: Differential effects of GP IIb/IIIa blockers on platelet activation marker P-selectin expression at hypothermia

Thrombosis Research

Volumn 122, Issue 3, 2008, Pages 383-389

  Straub, Andreas ^a   Schiebold, Daniela ^a   Wendel, Hans Peter ^a   Azevedo, Ruben ^a   Dietz, Klaus ^a   Ziemer, Gerhard ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Extracorporeal circulation; GP IIb IIIa blockade; Platelets

Indexed keywords

4 (4 AMIDINOPHENOXY)BUTYRYLASPARTYLVALINE; EPTIFIBATIDE; FIBRINOGEN RECEPTOR ANTAGONIST; PADGEM PROTEIN; THROMBIN ANTITHROMBIN COMPLEX; TIROFIBAN;

ANESTHESIA; ARTICLE; CIRCULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; EXTRACORPOREAL CIRCULATION; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

ADENOSINE DIPHOSPHATE; ANTITHROMBIN III; BLOOD PLATELETS; DIPEPTIDES; EXTRACORPOREAL CIRCULATION; FLOW CYTOMETRY; HUMANS; HYPOTHERMIA, INDUCED; MALE; P-SELECTIN; PEPTIDE HYDROLASES; PLATELET ACTIVATION; PLATELET COUNT; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; TEMPERATURE;

EID: 45849125010     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2008.01.001     Document Type: Article

References (23)

1. Li N., Astudillo R., Ivert T., and Hjemdahl P. Biphasic pro-thrombotic and inflammatory responses after coronary artery bypass surgery. J Thromb Haemost 1 (2003) 470-476
2. Weerasinghe A., and Taylor K.M. The platelet in cardiopulmonary bypass. Ann Thorac Surg 66 (1998) 2145-2152
3. Straub A., Breuer M., Wendel H.P., Peter K., Dietz K., and Ziemer G. Critical temperature ranges of hypothermia-induced platelet activation: possible implications for cooling patients in cardiac surgery. Thromb Haemost 97 (2007) 608-616
4. Hiramatsu Y., Gikakis N., Anderson III H.L., Gorman III J.H., Marcinkiewicz C., Gould R.J., et al. Tirofiban provides "platelet anesthesia" during cardiopulmonary bypass in baboons. J Thorac Cardiovasc Surg 113 (1997) 182-193
5. Bizzarri F., Scolletta S., Tucci E., Lucidi M., Davoli G., Toscano T., et al. Perioperative use of tirofiban hydrochloride (Aggrastat) does not increase surgical bleeding after emergency or urgent coronary artery bypass grafting. J Thorac Cardiovasc Surg 122 (2001) 1181-1185
6. C.M. Dyke, D. Bhatia, T.J. Lorenz, S.P. Marso, B.E. Tardiff, C. Hogeboom and R.A. Harrington Immediate coronary artery bypass surgery after platelet inhibition with eptifibatide: results from PURSUIT. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrelin Therapy. Ann Thorac Surg 2000;70:866-71; discussion 871-2.
7. Genoni M., Zeller D., Bertel O., Maloigne M., and Turina M. Tirofiban therapy does not increase the risk of hemorrhage after emergency coronary surgery. J Thorac Cardiovasc Surg 122 (2001) 630-632
8. Aoki T., Cox D., Senzaki K., Seki J., Tanaka A., Takasugi H., et al. The anti-platelet and anti-thrombotic effects of FK633, a peptide-mimetic GPIIB/IIIA antagonist. Thromb Res 81 (1996) 439-450
9. Schrör K., and Weber A.A. Comparative pharmacology of GP IIb/IIIa antagonists. J Thromb Thrombolysis 15 (2003) 71-80
10. Peter K., Schwarz M., Ylanne J., Kohler B., Moser M., Nordt T., et al. Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitors. Blood 92 (1998) 3240-3249
11. Bassler N., Loeffler C., Mangin P., Yuan Y., Schwarz M., Hagemeyer C.E., et al. A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists. Arterioscler Thromb Vasc Biol 27 (2007) e9-e15
12. Straub A., Azevedo R., Beierlein W., Wendel H.P., Dietz K., and Ziemer G. Glycoprotein IIb/IIIa inhibition reduces prothrombotic events under conditions of deep hypothermic circulatory arrest. Thromb Haemost 94 (2005) 115-122
13. Dickfeld T., Ruf A., Pogatsa-Murray G., Muller I., Engelmann B., Taubitz W., et al. Differential antiplatelet effects of various glycoprotein IIb-IIIa antagonists. Thromb Res 101 (2001) 53-64
14. Straub A., Azevedo R., Beierlein W., Wendel H.P., Dietz K., and Ziemer G. Tirofiban (Aggrastat) protects platelets and decreases platelet-granulocyte binding in an extracorporeal circulation model. Thorac Cardiovasc Surg 54 (2006) 162-167
15. Kanemitsu S., Nishikawa M., Onoda K., Shimono T., Shimpo H., Yazaki A., et al. Pharmacologic platelet anesthesia by glycoprotein IIb/IIIa complex antagonist and argatroban during in vitro extracorporeal circulation. J Thorac Cardiovasc Surg 126 (2003) 428-435
16. Kondo N., Wakayama F., Suzuki Y., Fukui K., Takaya S., and Fukuda I. The state of platelets preserved in extracorporeal circulation with a glycoprotein IIb/IIIa inhibitor. Thromb Res 113 (2004) 303-310
17. Tabata S., Yamaguchi S., Nagamine H., Tomita S., Arai S., Takemura H., et al. Efficacy of FK633, an ultra-short acting glycoprotein IIb/IIIa antagonist on platelet preservation during and after cardiopulmonary bypass. Eur J Cardiothorac Surg 26 (2004) 289-293
18. Schneider D.J., Taatjes D.J., and Sobel B.E. Paradoxical inhibition of fibrinogen binding and potentiation of alpha-granule release by specific types of inhibitors of glycoprotein IIb-IIIa. Cardiovasc Res 45 (2000) 437-446
19. Honda S., Tomiyama Y., Aoki T., Shiraga M., Kurata Y., Seki J., et al. Association between ligand-induced conformational changes of integrin IIbbeta3 and IIbbeta3-mediated intracellular Ca2+ signaling. Blood 92 (1998) 3675-3683
20. Blue R., Murcia M., Karan C., Jirouskova M., and Coller B.S. Application of high throughput screening to identify a novel αIIb-specific small molecule inhibitor of αIIbβ3-mediated platelet interaction with fibrinogen. Blood 111 3 (2008) 1248-1256 (Feb 1)
21. Xiao T., Takagi J., Coller B.S., Wang J.H., and Springer T.A. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature 432 (2004) 59-67
22. Gawaz M. Blood platelets (2001), New York Thieme, Stuttgart
23. Goto S., Tamura N., Li M., Handa M., Ikeda Y., Handa S., et al. Different effects of various anti-GPIIb-IIIa agents on shear-induced platelet activation and expression of procoagulant activity. J Thromb Haemost 1 (2003) 2022-2030