Combination of the Suzuki-Miyaura cross-coupling and nucleophilic aromatic substitution of hydrogen (S N H) reactions as a versatile route to pyrimidines bearing thiophene fragments

Tetrahedron

Volumn 68, Issue 27-28, 2012, Pages 5445-5452

  Verbitskiy, Egor V ^a   Cheprakova, Ekaterina M ^a   Slepukhin, Pavel A ^a   Kodess, Mikhail I ^a   Ezhikova, Marina A ^a   Pervova, Marina G ^a   Rusinov, Gennady L ^a,b   Chupakhin, Oleg N ^a,b   Charushin, Valery N ^a,b  

^a INSTITUTE OF ORGANIC SYNTHESIS   (Russian Federation)

^b URAL FEDERAL UNIVERSITY   (Russian Federation)

Author keywords

Microwave assisted synthesis; Nucleophilic aromatic substitution of hydrogen; Pyrimidines; Suzuki Miyaura reaction; Thiophenes

Indexed keywords

2 BROMOTHIOPHENE; 4 (5 BROMOTHIOPHEN 2 YL) 5 (THIOPHEN 2 YL) 3, 4 DIHYDROPYRIDIN 1 IUM; 4 (5 BROMOTHIOPHEN 2 YL) 5 THIOPHEN 2 YL PYRIMIDINE; 4 (5 BROMOTHIOPHEN 2 YL) PYRIMIDINE; 4 [2,2'] BITHIOPHENYL 5 YL PYRIMIDINE; 4 THIOPHEN 2 YL PYRIMIDINE; 4,5 DITHIOPHEN 2 YL PYRIMIDINE; 5 BROMO 4 (5 BROMOTHIOPHEN 2 YL) PYRIMIDINE; 5 BROMO 4 THIOPHEN 2 YL PYRIMIDINE; 5 BROMOPYRIMIDINE; 5 THIOPHEN 2 YL PYRIMIDINE; HYDROGEN; PYRIMIDINE DERIVATIVE; THIOPHENE; THIOPHENE (THIOPHENYL)PYRIMIDINE; TRIFLUOROACETATE 5 BROMO 4 (5 BOMOTHIOPHEN 2 YL) 3,4 DIHYDROPYRIMIDINIUM; TRIFLUOROACETATE 5 BROMO 4 THIOPHEN 2 YL 3,4 DIHYDROPYRIMIDINIUM; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; GAS LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEOPHILIC AROMATIC SUBSTITUTION OF HYDROGEN; PRIORITY JOURNAL; SUBSTITUTION REACTION; SUZUKI MIYAURA CROSS COUPLING; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

EID: 84862001348     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2012.04.095     Document Type: Article

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