Ectopic acromegaly due to a pancreatic neuroendocrine tumor producing growth hormone-releasing hormone

Endocrine Practice

Volumn 17, Issue 1, 2011, Pages 79-84

  Weiss, Danielle E ^a   Vogel, Hannes ^a   Lopes, M Beatriz S ^b   Chang, Steven D ^a   Katznelson, Laurence ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CABERGOLINE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; OCTREOTIDE; PEGVISOMANT; PENTETREOTIDE; PROLACTIN; SOMATOMEDIN C;

ABDOMINAL PAIN; ABDOMINAL SCINTISCANNING; ACROMEGALY; ADULT; ARTICLE; CASE REPORT; FEMALE; GENE MUTATION; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE SECRETING CELL; HISTOPATHOLOGY; HORMONE RELEASE; HUMAN; MULTIPLE ENDOCRINE NEOPLASIA; NEUROENDOCRINE TUMOR; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS RESECTION; PANCREAS TUMOR; PARATHYROID HYPERPLASIA;

ACROMEGALY; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MIDDLE AGED; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS;

EID: 79952429652     PISSN: 1530891X     EISSN: None     Source Type: Journal    
DOI: 10.4158/EP10165.CR     Document Type: Article

References (20)

1. Chanson P, Salenave S. Acromegaly. Orphanet J Rare Dis. 2008;3:17.
2. Agha, Farrell L, Downey P, Keeling P, Leen E, Sreenan S. Acromegaly secondary to growth hormone releasing hormone secretion. Ir J Med Sci. 2004;173:215-216. (Pubitemid 40347679)
3. Doga M, Bonadonna S, Burattin A, Giustina A. Ectopic secretion of growth hormone-releasing hormone (GHRH) in neuroendocrine tumors: Relevant clinical aspects. Ann Oncol. 2001;12(Suppl 2):S89-S94. (Pubitemid 33069694)
4. Nasr C, Mason A, Mayberg M, Staugaitis SM, Asa SL. Acromegaly and somatotroph hyperplasia with adenomatous transformation due to pituitary metastasis of a growth hormone-releasing hormone-secreting pulmonary endocrine carcinoma. J Clin Endocrinol Metab. 2006;91:4776-4780. (Pubitemid 44917306)
5. Losa M, von Werder K. Pathophysiology and clinical aspects of the ectopic GH-releasing hormone syndrome. Clin Endocrinol (Oxf). 1997;47:123-135. (Pubitemid 27359892)
6. Biermasz NR, Smit JW, Pereira AM, Frölich M, Romijn JA, Roelfsema F. Acromegaly caused by growth hormone-releasing hormone-producing tumors: Long-term observational studies in three patients. Pituitary. 2007;10:237-249. (Pubitemid 350055035)
7. Colak Ozbey N, Kapran Y, Bozbora A, Erbil Y, Tascioglu C, Asa SL. Ectopic growth hormone-releasing hormone secretion by a neuroendocrine tumor causing acromegaly: Long-term follow-up results. Endocr Pathol. 2009;20:127-132.
8. Liu SW, van de Velde CJ, Heslinga JM, Kievit J, Roelfsema F. Acromegaly caused by growth hormone-relating hormone in a patient with multiple endocrine neoplasia type I. Jpn J Clin Oncol. 1996;26:49-52. (Pubitemid 126469266)
9. Cwikla JB, Nasierowska-Guttmejer A, Jeziorski KG, et al. Diagnostic imaging approach to gastro-enteropancreatic carcinomas of neuroendocrine origin - single NET center experience in Poland. Neuro Endocrinol Lett. 2007;28:789-800.
10. Ehehalt F, Saeger HD, Schmidt CM, Grützmann R. Neuroendocrine tumors of the pancreas. Oncologist. 2009;14:456-467.
11. Kouvaraki MA, Shapiro SE, Cote GJ, et al. Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. World J Surg. 2006;30:643-653. (Pubitemid 43724089)
12. Dean PG, van Heerden JA, Farley DR, et al. Are patients with multiple endocrine neoplasia type I prone to premature death? World J Surg. 2000;24:1437-1441.
13. de Jager CM, de Heide LJ, van den Berg G, Wolthuis A, van Schelven WD. Acromegaly caused by a growth hormone-releasing hormone secreting carcinoid tumour of the lung: The effect of octreotide treatment. Neth J Med. 2007;65:263-266.
14. Drange MR, Melmed S. Long-acting lanreotide induces clinical and biochemical remission of acromegaly caused by disseminated growth hormone-releasing hormone-secreting carcinoid. J Clin Endocrinol Metab. 1998;83:3104-3109. (Pubitemid 28500942)
15. van Hoek M, Hofland LJ, de Rijke YB, et al. Effects of somatostatin analogs on a growth hormone-releasing hormone secreting bronchial carcinoid, in vivo and in vitro studies. J Clin Endocrinol Metab. 2009;94:428-433.
16. Bertherat J, Turpin G, Rauch C, et al. Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide. J Clin Endocrinol Metab. 1994;79:1457-1464.
17. Othman NH, Ezzat S, Kovacs K, et al. Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly. Clin Endocrinol (Oxf). 2001;55:135-140. (Pubitemid 34204310)
18. Jaffe CA, DeMott-Friberg R, Frohman LA, Barkan AL. Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist. J Clin Endocrinol Metab. 1997;82:634-637. (Pubitemid 27068642)
19. Trouillas J, Labat-Moleur F, Sturm N, et al; Groupe d'études des Tumeurs Endocrines. Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): A case-control study in a series of 77 patients versus 2509 non-MEN1 patients. Am J Surg Pathol. 2008;32:534-543. (Pubitemid 351458295)
20. Kineman RD, Teixeira LT, Amargo GV, Coschigano KT, Kopchick JJ, Frohman LA. The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling. Endocrinology. 2001;142:3764-3773. (Pubitemid 32802647)