Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): A case-control study in a series of 77 patients versus 2509 non-MEN1 patients

American Journal of Surgical Pathology

Volumn 32, Issue 4, 2008, Pages 534-543

  Trouillas, Jacqueline ^a,b,c   Labat Moleur, Françoise ^d   Sturm, Nathalie ^d   Kujas, Michèle ^e   Heymann, Marie Françoise ^f   Figarella Branger, Dominique ^g   Patey, Martine ^h   Mazucca, Marc ⁱ   Decullier, Evelyne ^c   Vergès, Bruno ^j   Chabre, Olivier ^d   Calender, Alain ^c  

^a INSERM   (France)

^b UNIVERSITÉ DE LYON   (France)

^c EDOUARD HERRIOT HOSPITAL   (France)

^d GRENOBLE UNIVERSITY HOSPITAL   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f CHU de Nantes   (France)

^g TIMONE HOSPITAL   (France)

^h SERVICE DE DERMATOLOGIE   (France)

ⁱ LILLE UNIVERSITY HOSPITAL   (France)

^j DIJON UNIVERSITY HOSPITAL   (France)

more..

Author keywords

MEN1; Menin gene; Pituitary; Pituitary hyperplasia; Pituitary tumors

Indexed keywords

CORTICOTROPIN; FOLLITROPIN; GROWTH HORMONE; KI 67 ANTIGEN; LUTEINIZING HORMONE; METHIONINE; PROLACTIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; FRAMESHIFT MUTATION; GENE DELETION; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; HORMONE RELEASE; HUMAN; HUMAN TISSUE; HYPOPHYSIS TUMOR; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MULTIPLE ENDOCRINE NEOPLASIA; NONSENSE MUTATION; PLURIHORMONAL ADENOMA;

ADENOMA; ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CELL PROLIFERATION; FEMALE; FOLLICLE STIMULATING HORMONE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN GROWTH HORMONE; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LUTEINIZING HORMONE; MALE; MIDDLE AGED; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; MUTATION; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PITUITARY GLAND; PITUITARY NEOPLASMS; PROLACTIN; PROTO-ONCOGENE PROTEINS; THYROTROPIN;

EID: 41449096570     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31815ade45     Document Type: Article

References (51)

1. Agarwal SK, Ice Burns A, Sukhodolets KE, et al. Molecular pathology of the MEN1 genes. Ann NY Acad Sci. 2004;1014:189-198.
2. Anlauf M, Schlenger R, Perren A, et al. Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome. Am J Surg Pathol. 2006;30:560-574.
3. Asa SL. Tumors of the Pituitary Gland. 3rd ed. Washington, DC: Armed Forces Institute of Pathology; 1997.
4. Berger G, Trouillas J, Bloch B, et al. Multihormonal carcinoid tumor of the pancreas secreting growth hormone-releasing factor as a cause of acromegaly. Cancer. 1984;54:2097-2108.
5. Bertolino P, Tong WM, Galendo M, et al. Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type1. Mol Endocrinol. 2003;17:1880-1892.
6. Biondi CA, Gartside MG, Waring P, et al. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol. 2004;24:3125-3131.
7. Burgess JR, Shepherd JJ, Parameswaran V, et al. Prolactinomas in a large kindred with multiple endocrine neoplasia type1: clinical features and inheritance pattern. J Clin Endocrinol Metab. 1996;81:1841-1845.
8. Calender A, Morrison CD, Komminoth P, et al. Multiple endocrine neoplasia type 1. In: DeLellis RA, Lloyd RV, Heitz PU, et al, eds. Pathology and Genetics: Tumours of Endocrine Organs. WHO Classification of Tumors. Lyon, France: IARC Press; 2004:218-227.
9. Capella C, Riva C, Leutner M, et al. Pituitary lesions in multiple endocrine neoplasia syndrome (MEN1) type 1. Pathol Res Pract. 1995;191:343-347.
10. Casilli F, Di Rocco ZC, Gad S, et al. Rapid detection of novel BRCA1 rearrangements in high-risk breast-ovarian cancer families using multiplex PCR of short fluorescent fragments. Hum Mutat. 2002;20:218-226.
11. Chandrasekharappa SC, Guru SC, Manickam P, et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 1997;276:404-407.
12. Colman SD, Rasmussen SA, Ho VT, et al. Somatic mosaicism in a patient with neurofibromatosis type 1. Am J Hum Genet. 1996;58:484-490.
13. Crabtree JS, Scacheri PC, Ward JM, et al. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci USA. 2001;98:1118-1123.
14. Delgrange E, Tourniaire J, Maiter D, et al. Sex-related difference in the growth of prolactinomas: a clinical and proliferation marker study. J Clin Endocrinol Metab. 1997;82:2102-2107.
15. Evans CO, Brown MR, Parks JS, et al. Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors. J Endocrinol Invest. 2000;23:304-309.
16. Franklin DS, Godfrey VL, O'Brien DA, et al. Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Mol Cell Biol. 2000;20:6147-6158.
17. Giraud S, Zhang CX, Serova-Sinilnikova O, et al. Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders. Am J Hum Genet. 1998;63:455-467.
18. Guillemin R, Brazeau P, Böhlen P, et al. Growth hormone releasing factor from a human pancreatic tumor that caused acromegaly. Science. 1982;218:585-587.
19. Guo SS, Sawicki MP. Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1. Mol Endocrinol. 2001;15:1653-1664.
20. Hao W, Skarulis MC, Simonds WF, et al. MEN1 variant with frequent prolactinoma and rare gastrinoma. J Clin Endocrinol Metab. 2004;89:3776-3784.
21. Heitz PU. Multihormonal pituitary adenomas. Horm Res. 1979;10:1-13.
22. Heitz PU, Komminoth P, Perren A, et al. Pancreatic endocrine tumours. In: DeLellis RA, Lloyd RV, Heitz PU, et al, eds. Pathology and Genetics: Tumours of Endocrine Organs. WHO Classification of Tumors. Lyon, France: IARC Press; 2004:177-182.
23. Klöppel G, Willemer S, Stamm B, et al. Pancreatic lesions and hormonal profile of pancreatic tumors in multiple endocrine neoplasia type I: an immunocytochemical study of nine patients. Cancer. 1986;57:1824-1832.
24. Komminoth P, Heitz PU, Klöppel G. Pathology of MEN-1: morphology, clinicopathologic correlations and tumour development. J Intern Med. 1998;243:455-464.
25. Kouvaraki MA, Lee JE, Shapiro SE, et al. Genotype-phenotype analysis in multiple endocrine neoplasia type 1. Arch Surg. 2002;137:641-647.
26. Labat-Moleur F, Trouillas J, Seret-Begue D, et al. Evaluation of 28 monoclonal and polyclonal antibodies used in diagnosis of pituitary adenomas. Path Res Pract. 1991;187:534-538.
27. Le Bodic MF, Heymann MF, Lecomte M, et al. Immunohistochemical study of 100 pancreatic tumors in 28 patients with multiple endocrine neoplasia, type I. Am J Surg Pathol. 1996;20:1378-1384.
28. Lecomte P, Jan M, Trouillas J, et al. Les adénomes hypophysaires multiples. Feuill Biol. 2001;42:57-66.
29. Lemmens I, Van de Ven WJ, Kas K, et al. Identification of multiple endocrine neoplasia type 1 (MEN1) gene: the European Consortium on MEN1. Hum Mol Genet. 1997;6:1177-1183.
30. Lloyd RV, Kovacs K, Young WF Jr, et al. Pituytary tumours: introduction. In: DeLellis RA, Lloyd RV, Heitz PU, et al, eds. Pathology and Genetics: Tumours of Endocrine Organs. WHO Classification of Tumors. Lyon, France: IARC Press; 2004:10-13.
31. Marx SJ, Nieman LK. Aggressive pituitary tumors in MEN1: do they refute the two-hit model of tumorigenesis? J Clin Endocrinol Metab. 2002;87:453-456.
32. Marx SJ, Agarwal SK, Kester MB, et al. Germline and somatic mutation of the gene for multiple endocrine neoplasia type 1 (MEN1). J Int Med. 1998;243:447-453.
33. Marx SJ, Agarwal SK, Kester MB, et al. Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasia. Recent Prog Horm Res. 1999;54:397-438.
34. Meij BP, Lopes MB, Vance ML, et al. Double pituitary lesions in three patients with Cushing's disease. Pituitary. 2000;3:159-168.
35. O'Brien T, O'Riordan DS, Gharib H, et al. Results of treatment of pituitary disease in multiple endocrine neoplasia, type 1. Neurosurgery. 1996;39:273-279.
36. Poncin J, Stevenaert A, Beckers A. Somatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis. Eur J Endocrinol. 1999;140:573-576.
37. Prezant TR, Levine J, Melmed S. Molecular characterization of the MEN1 tumor suppressor gene in sporadic pituitary tumors. J Clin Endocrinol Metab. 1998;83:1388-1391.
38. Sahdev A, Jäger R. Bilateral pituitary adenomas occurring with multiple endocrine neoplasia type one. Am J Neuroradiol. 2000;21:1067-1069.
39. Samaan NA, Ouais S, Ordonez NG, et al. Multiple endocrine syndrome type 1. Clinical, laboratory findings, and management in five families. Cancer. 1989;64:741-752.
40. Sassolas G, Trouillas J, Berger F, et al. Hormonal and pathological studies of endocrine tissues in a patient presenting with a multihormonal carcinoid tumor of the pancreas with acromegaly. Regulatory Peptides in Digestive, Nervous and Endocrine Systems. INSERM Symposium. 1985;25:379-387.
41. Scheithauer BW, Laws ER, Kovacs K, et al. Pituitary adenomas of the multiple endocrine neoplasia type 1 syndrome. Semin Diagn Pathol. 1987;4:205-211.
42. Skogseid B, Eriksson B, Lundqvist G, et al. Multiple endocrine neoplasia type 1; a 10-year prospective screening study in four kindreds. J Clin Endocrinol Metab. 1991;73:281-287.
43. Trouillas J, Girod C. Pathology of pituitary adenomas. In: Landolt AM, Vance ML, Reilly PL, eds. Pituitary Adenomas. Churchill Livingstone: New-York Publishers; 1996:27-46.
44. Trouillas J, Girod C, Claustrat B, et al. Spontaneous pituitary tumors in the Wistar/Furth/Ico rat strain. An animal model of human prolactin adenoma. Am J Pathol. 1982;109:57-70.
45. Trouillas J, Girod C, Sassolas G, et al. Immunocytochemistry, what does it add to clinical management of pituitary adenomas? Adv Biosci. 1988;69:11-20.
46. Trouillas J, Guigard MP, Fonlupt P, et al. Mapping of corticotropic cells in the normal human pituitary. J Histochem Cytochem. 1996;44:473-479.
47. Vasen HFA, Lamers CBHW, Cees JML. Screening for the multiple endocrine neoplasia syndrome type 1: a study of 11 kindreds in the Netherlands. Arch Intern Med. 1989;149:2717-2722.
48. Verges B, Boureille F, Goudet P, et al. Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study. J Clin Endocrinol Metab. 2002;87:457-465.
49. Wautot V, Vercherat C, Lespinasse J, et al. Germline mutation profile of MEN1 in multiple endocrine neoplasia type1: search for correlation between phenotype and functional domains of MEN1 protein. Human Mutat. 2002;20:35-47.
50. Wrocklage C, Gold H, Hackl W, et al. Increased menin expression in sporadic pituitary adenomas. Clin Endocrinol. 2002;56:589-594.
51. Zhuang Z, Ezzat SZ, Vortmeyer AO, et al. Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Res. 1997;57:5446-5451.