Apple pomace, a by-product from the Asturian cider industry, inhibits herpes simplex virus types 1 and 2 in vitro replication: Study of its mechanisms of action

Journal of Medicinal Food

Volumn 15, Issue 6, 2012, Pages 581-587

  Álvarez, Ángel L ^a   Melón, Santiago ^b   Dalton, Kevin P ^a   Nicieza, Inés ^a   Roque, Annele ^c   Suárez, Belén ^d   Parra, Francisco ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b Central University Hospital of Asturias   (Spain)

^c UNIVERSITY OF HAVANA   (Cuba)

^d Servicio Regional de Investigación y Desarrollo Agroalimentario de Asturias   (Spain)

Author keywords

antiviral; apple pomace; HSV; polyphenols

Indexed keywords

ACICLOVIR; APPLE POMACE EXTRACT; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PROCYANIDIN; QUERCITRIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; APPLE POMACE; ARTICLE; CELL SURFACE; CIDER; DRUG MECHANISM; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS ATTACHMENT; VIRUS ENTRY; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; FOOD INDUSTRY; FRUIT; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; MALUS; PHYTOTHERAPY; PLANT PREPARATIONS; VERO CELLS; VIRUS REPLICATION;

HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; MALUS X DOMESTICA; SIMPLEXVIRUS;

EID: 84861996389     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2011.0308     Document Type: Article

References (28)

1. Suárez B, Álvarez AL, Diñeiro Y, del Barrio G, Picinelli A, Parra F: Phenolic profiles, antioxidant activity and in vitro antiviral properties of apple pomace. Food Chem 2010;120:339-342.
2. Masooi FA, Sharma B, Chauhan GS: Use of apple pomace as a source of dietary fiber in cakes. Plant Foods Hum Nutr 2002;57:121-128. (Pubitemid 34536020)
3. Figuerola F, Hurtado M, Estévez AM, Chiffelle I, Asenjo F: Fibre concentrates from apple pomace and citrus peel as potential fibre sources for food enrichment. Food Chem 2005;91:395-401. (Pubitemid 40023269)
4. Leontowicz H, Gorinstein S, Lojek A, Leontowicz M, CižM, Soliva-Fortuny R, Park YS, Jung ST, Trakhtenberg S, Martin-Belloso O: Comparative content of some bioactive compounds in apples, peaches and pears and their influence on lipids and antioxidant capacity in rats. J Nutr Biochem 2002;13:603-610. (Pubitemid 35246550)
5. Boyer J, Liu RH: Apple phytochemicals and their health benefits. Nutr J 2004;3:5.
6. Whitley RJ, Kimberlin DW, Roizman B: Herpes simplex viruses. Clin Infect Dis 1998;26:97-109.
7. Whitley RJ, Roizman B: Herpes simplex virus infections. Lancet 2001;357:1513-1518. (Pubitemid 32488876)
8. Diñeiro Y, Suárez B, Picinelli A: Phenolic and antioxidant composition of by-products from the cider industry: apple pomace. Food Chem 2009;117:731-738.
9. Reed LJ, Muench H: A simple method of estimating fifty per cent endpoints. Am J Hyg 1938;27:493-497.
10. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
11. Al Jabri AA, Wigg MD, Oxford JS: Initial in vitro screening of drug candidates for their potential antiviral activities. In: Virology Methods Manual. (Mahy BWJ, Kangro HO, eds.) Academic Press, London, 1996, pp. 293-307.
12. Cann A: Antiviral testing. In: Virus Culture: A Practical Approach. (Cann A, ed.) Oxford University Press, New York, 1999, pp. 201-219.
13. del Barrio G, Spengler I, García T, Roque A, Álvarez AL, Calderón JS, Parra F: Antiviral activity of Ageratina havanensis and major chemical compounds from the most active fraction. Braz J Pharmacogn 2011;21:915-920.
14. Álvarez AL, Habtemariam S, Juan-Badaturuge M, Jackson C, Parra F: In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: an approach to their mechanisms of action. Phytother Res 2011;25:296-301.
15. Álvarez AL, del Barrio G, Kourí V, Martínez PA, Suárez B, Parra F: In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis. Phytomedicine 2009;16:960-966.
16. Gescher K, Hensel A, Hafezi W, Derksen A, Kuhn J: Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1. Antiviral Res 2011;89:9-18.
17. Tsuchiya Y, Shimizu M, Hiyama Y, Itoh K, Hashimoto Y, Nakayama M, Horie T, Morita N: Antiviral activity of natural occurring flavonoids in vitro. Chem Pharm Bull 1985;33:3881-3886. (Pubitemid 16235643)
18. De Clercq E: Antivirals for the treatment of herpesvirus infections. J Antimicrob Chemother 1993;32 Suppl A:121-132.
19. Sydiskis RJ, Owen DG, Lohr JL, Rosler KH, Blomster RN: Inactivation of enveloped viruses by anthraquinones extracted from plants. Antimicrob Agents Chemother 1991;35:2463-2466.
20. de Bruyne T, Pieters L, Witvrouw M, De Clercq E, Vanden Berghe D, Vlietinck AJ: Biological evaluation of proanthocyanidin dimers and related polyphenols. J Nat Prod 1999;62:954-958. (Pubitemid 29357439)
21. Hu JM, Hsiung GD: Evaluation of new antiviral agents: I. In vitro perspectives. Antiviral Res 1989;11:217-232. (Pubitemid 19182395)
22. Phelan A, Dunlop J, Patel AH, Stow ND, Clements JB: Nuclear sites of herpes simplex virus type 1 DNA replication and transcription colocalize at early times postinfection and are largely distinct from RNA processing factors. J Virol 1997;71:1124-1132. (Pubitemid 27030284)
23. Oh J, Fraser NW: Temporal association of the herpes simplex virus genome with histone proteins during a lytic infection. J Virol 2008;82:3530-3537. (Pubitemid 351429928)
24. Mucsi I, Gyulai Z, Beladi I: Combined effects of flavonoids and acyclovir against herpes viruses in cell cultures. Acta Microbiol Hung 1992;39:137-147.
25. Chiang LC, Chiang W, Chang MY, Ng LT, Lin CC: Antiviral activity of Plantago major extracts and related compounds in vitro. Antiviral Res 2002;55:53-62. (Pubitemid 34655642)
26. Schnitzler P, Neuner A, Nolkemper S, Zundel C, Nowack H, Sensch KH, Reichling J: Antiviral activity and mode of action of propolis extracts and selected compounds. Phytother Res 2010;24 Suppl 1:S20-S28.
27. Abou-Karam M, Shier WT: Isolation and characterization of an antiviral flavonoid from Waldsteinia fragarioides. J Nat Prod 1992;55:1525-1527.
28. Kane CJ, Menna JH, Sung CC, Yeh YC: Methyl gallate, methyl-3,4,5- trihydoxybenzoate, is a potent and highly specific inhibitor of herpes simplex virus in vitro. II. Antiviral activity of methyl gallate and its derivatives. Biosci Rep 1988;8:95-102.