Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: A pilot study

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 6, 2012, Pages

  Monteleone, Palmiero ^a,b   Piscitelli, Fabiana ^c   Scognamiglio, Pasquale ^a   Monteleone, Alessio Maria ^a   Canestrelli, Benedetta ^a   Di Marzo, Vincenzo ^c   Maj, Mario ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ANANDAMIDE; ENDOCANNABINOID; GHRELIN; GLUCOSE; N OLEOYLETHANOLAMINE; PALMIDROL;

ADULT; ARTICLE; BODY MASS; CALORIC INTAKE; CONTROLLED STUDY; EATING; FEEDING BEHAVIOR; FEMALE; FOOD AVAILABILITY; FOOD DEPRIVATION; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEDONIC EATING; HORMONE ACTION; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUNGER; MALE; NORMAL HUMAN; NUTRIENT CONTENT; PILOT STUDY; PLEASURE; PRIORITY JOURNAL; SATIETY; SIGNAL TRANSDUCTION;

ADULT; APPETITE; ARACHIDONIC ACIDS; BLOOD GLUCOSE; ENDOCANNABINOIDS; ENERGY INTAKE; FEEDING BEHAVIOR; FEMALE; GHRELIN; GLYCERIDES; HUMANS; MALE; OLEIC ACIDS; PALMITIC ACIDS; PILOT PROJECTS; PLEASURE; POLYUNSATURATED ALKAMIDES; REFERENCE VALUES; SATIETY RESPONSE; YOUNG ADULT;

EID: 84861988176     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-3018     Document Type: Article

References (30)

1. Murphy KG, Bloom SR 2006 Gut hormones and the regulation of energy homeostasis. Nature 444:854-859 (Pubitemid 46024992)
2. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671 (Pubitemid 30205071)
3. Lowe MR, Butryn ML 2007 Hedonic hunger: a new dimension of appetite? Physiol Behav 91:432-439 (Pubitemid 47016537)
4. Finlayson G, King N, Blundell JE 2007 Liking vs. wanting food: importance for human appetite control and weight regulation. Neurosci Biobehav Rev 31:987-1002 (Pubitemid 47332618)
5. Lutter M, Nestler EJ 2009 Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr 139:629-632
6. Jerlhag E, Egecioglu E, Dickson SL, Douhan A, Svensson L, Engel JA 2007 Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addict Biol 12:6-16 (Pubitemid 46405994)
7. Di Marzo V, Ligresti A, Cristino L 2009 The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation. Int J Obes (Lond) 33:18-24
8. First MB, Gibbon M, Spitzer RL, Williams JB 1996 Structured clinical interview for Axis I DSM-IV disorders-non-patient ed (SCID-I/NP, version 2.0). New York: New York State Psychiatric Institute, Biometrics Research Department
9. Monteleone P, Matias I, Martiadis V, De Petrocellis L, Maj M, Di Marzo V 2005 Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. Neuropsychopharmacology 30:1216-1221 (Pubitemid 40720981)
10. Annuzzi G, Piscitelli F, Di Marino L, Patti L, Giacco R, Costabile G, Bozzetto L, Riccardi G, Verde R, Petrosino S, Rivellese AA, Di Marzo V 2010 Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients. Lipids Health Dis 9:43
11. Dixon J 1985 BMDP statistical software. Berkeley, CA: University of California Press
12. Di Marzo V, Goparaju SK, Wang L, Liu J, Bätkai S, Järai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, Kunos G 2001 Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410:822-825 (Pubitemid 32303781)
13. Simonian HP, Kresge KM, Boden GH, Parkman HP 2005 Differential effects of sham feeding and meal ingestion on ghrelin and pancreatic polypeptide levels: evidence for vagal efferent stimulation mediating ghrelin release. Neurogastroenterol Motil 17:348-354 (Pubitemid 40768907)
14. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719 (Pubitemid 33641587)
15. Malik S, McGlone F, Bedrossian D, Dagher A 2008 Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 7:400-409 (Pubitemid 351598026)
16. Berridge KC, Robinson TE 1998 What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28:309-369 (Pubitemid 29012677)
17. Melis T, Succu S, Sanna F, Boi A, Argiolas A, Melis MR 2007 The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food. Neurosci Lett 419:231-235 (Pubitemid 46755483)
18. Simiand J, Keane M, Keane PE, Soubrië P 1998 SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Behav Pharmacol 9:179-181
19. Izzo AA, Piscitelli F, Capasso R, Aviello G, Romano B, Borrelli F, Petrosino S, Di Marzo V 2009 2009 Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. Br J Pharmacol 158:451-461
20. DiPatrizio NV, Astarita G, Schwartz G, Li X, Piomelli D 2011 Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci USA 108:12904-12908
21. Di Marzo V 2011 Endocannabinoids: an appetite for fat. Proc Natl Acad Sci USA 108:12567-12568
22. Caraceni P, Viola A, Piscitelli F, Giannone F, Berzigotti A, Cescon M, Domenicali M, Petrosino S, Giampalma E, Riili A, Grazi G, Golfieri R, Zoli M, Bernardi M, Di Marzo V 2010 Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. Liver Int 30:816-825
23. Centonze D, Battistini L, Maccarrone M 2008 The endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases. Curr Pharm Des 14:2370-2342
24. Kola B, Farkas I, Christ-Crain M, Wittmann G, Lolli F, Amin F, Harvey-White J, Liposits Z, Kunos G, Grossman AB, Fekete C, Korbonits M 2008 The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PloS One 3:e1797
25. Cani PD, Montoya ML, Neyrinck AM,Delzenne NM, Lambert DM 2004 Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide. Br J Nutr 92:757-761 (Pubitemid 39562153)
26. Gatta-Cherifi B, Matias I, Vallëe M, Tabarin A, Marsicano G, Piazza PV, Cota D 16 August 2011 Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity. Int J Obes (Lond) 10.1038/ijo. 2011.165
27. Mascia P, Pistis M, Justinova Z, Panlilio LV, Luchicchi A, Lecca S, Scherma M, Fratta W, Fadda P, Barnes C, Redhi GH, Yasar S, Le Foll B, Tanda G, Piomelli D, GoldbergSR2011 Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry 69:633-641
28. Matias I, Gonthier MP, Orlando P, Martiadis V, De Petrocellis L, Cervino C, Petrosino S, Hoareau L, Festy F, Pasquali R, Roche R, Maj M, Pagotto U, Monteleone P, Di Marzo V 2006 Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia. J Clin Endocrinol Metab 91:3171-3180 (Pubitemid 44271774)
29. Matias I, Gonthier MP, Petrosino S, Docimo L, Capasso R, Hoareau L, Monteleone P, Roche R, Izzo AA, Di Marzo V 2007 Role and regulation of acylethanolamides in energy balance: focus on adipocytes and beta-cells. Br J Pharmacol 152:676-690 (Pubitemid 350041540)
30. Di Marzo V, Verrijken A, Hakkarainen A, Petrosino S, Mertens I, Lundbom N, Piscitelli F, Westerbacka J, Soro-Paavonen A, Matias I, Van Gaal L, Taskinen MR 2009 Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. Eur J Endocrinol 161:715-722