An in vitro evaluation of the effects of homocysteine thiolactone on key steps of angiogenesis and tumor invasion

Biochemical and Biophysical Research Communications

Volumn 311, Issue 3, 2003, Pages 649-653

  Martínez Poveda, Beatriz ^a   Chavarría, Teresa ^a   Sánchez Jiménez, Francisca ^a   Quesada, Ana R ^a   Medina, Miguel Ángel ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Angiogenesis; Bovine aorta endothelial cells; Homocysteine; Homocysteine thiolactone; HT 1080 fibrosarcoma cells

Indexed keywords

GELATINASE A; GELATINASE B; HOMOCYSTEINE; HOMOCYSTEINE THIOLACTONE;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CANCER INVASION; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EVALUATION; FIBROSARCOMA; HUMAN; HUMAN CELL; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; TUMOR CELL;

BOVINAE;

EID: 0242493262     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.10.044     Document Type: Article

References (26)

1. Medina M.A., Amores-Sánchez M.I. Homocysteine: an emergent cardiovascular risk factor? Eur. J. Clin. Invest. 30:2000;754-762.
2. Hankey G.J., Eikelboom J.W. Homocysteine and vascular disease. Lancet. 354:1999;407-413.
3. Medina M.A., Urdiales J.L., Amores-Sánchez M.I. Roles of homocysteine in cell metabolism. Old and new functions. Eur. J. Biochem. 268:2001;3871-3882.
4. The Homocysteine Study Collaboration, Homocysteine and the risk of ischemic heart disease and stroke. A meta-analysis, JAMA 288 (2002) 2015-2023.
5. Refsum H., Ueland P.M., Nygard O., Vollset S.E. Homocysteine and cardiovascular disease. Annu. Rev. Med. 49:1998;31-62.
6. Duan J., Murohara T., Ikeda H., Sasaki K., Shintani S., Akita T., Shimada T., Imaizumi T. Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia. Arteroscler. Thromb. Vasc. Biol. 20:2000;2579.
7. Nagai Y., Tasaki H., Takatsu H., Nihei S., Yamashita K., Toyokawa T., Nakashima Y. Homocysteine inhibits angiogenesis in vitro and in vivo. Biochem. Biophys. Res. Commun. 281:2001;726-731.
8. Rodríguez-Nieto S., Chavarría T., Martínez-Poveda B., Sánchez-Jiménez F., Quesada A.R., Medina M.A. Anti-angiogenic effects of homocysteine on cultured endothelial cells. Biochem. Biophys. Res. Commun. 293:2002;497-500.
9. Chavarría T., Sánchez-Jiménez F., Quesada A.R., Medina M.A. Homocysteine inhibits the proliferation and invasive potential of HT-1080 human fibrosarcoma cells. Biochem. Biophys. Res. Commun. 301:2003;540-544.
10. Chavarría T., Rodríguez-Nieto S., Sánchez- Jiménez F., Quesada A.R., Medina M.A. Homocysteine is apotent inhibitor of human tumor cell gelatinases. Biochem. Biophys. Res. Commun. 303:2003;572-575.
11. Jakubowski H., Goldman E. Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells. FEBS Lett. 317:1993;237-240.
12. Jakubowski H., Zhang L., Bardeguez A., Aviv A. Homocysteine thiolactone and protein homocysteinylation in human endothelial cells. Implications for atherosclerosis. Circ. Res. 87:2000;45-51.
13. Jakubowski H. Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J. Nutr. 130:2000;377S-381S.
14. Jakubowski H. Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J. 13:1999;2277-2283.
15. Jakubowski H. Homocysteine is a protein amino acid in humans: implications for homocysteine-linked disease. J. Biol. Chem. 277:2002;30425-30428.
16. 12 and causes cytotoxicity in HL60 cells: methionine protects cells completely. Blood. 89:1997;4600-4607.
17. Hansen D.K., Grafton T.F., Melnyk S., James S.J. Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro. Reprod. Toxicol. 15:2001;239-244.
18. Djurhuus R., Svardal A.M., Ueland P.M., Male R., Lillehaug J.R. Growth support and toxicity of homocysteine and its effects on methionine metabolism in non-transformed and chemically transformed C3H/10T1/2 cells. Carcinogenesis. 9:1988;9-16.
19. Mercié P., Garnier O., Lascoste L., Renard M., Closse C., Durrieu F., Marit G., Boisseau R.M., Belloc F. Homocysteine-thiolactone induces caspase-independent vascular endothelial cell death with apoptotic features. Apoptosis. 5:2000;403-411.
20. Huang R.F.S., Huang S.M., Lin B.S., Wei J.S., Liu T.Z. Homocysteine thiolactone induces apoptotic DNA damage mediated by increased intracellular hydrogen peroxide and caspase 3 activation in HL-60 cells. Life Sci. 68:2001;2799-2811.
21. Endresen P.C., Eide T.J., Aarbakke J. Cell death initiated by 3-deazaadenosine in HL-60 cells is apoptosis and is partially inhibited by homocysteine. Biochem. Pharmacol. 46:1993;1893-1901.
22. Liotta L.A., Steeg P.S., Stetler-Stevenson W.G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell. 64:1991;327-336.
23. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell. 100:2000;57-70.
24. Fajardo I., Quesada A.R., Núñez de Castro I., Sánchez-Jiménez F., Medina M.A. A comparative study of the effects of genistein and 2-methoxyestradiol on the proteolytic balance and tumour cell proliferation. Br. J. Cancer. 80:1999;17-24.
25. Albini A., D'Agostini F., Giunciuglio D., Paglieri I., Balansky R., De Flora S. Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine. Int. J. Cancer. 61:1995;121-129.
26. Cai T., Fassina G., Morini M., Aluigi M.G., Masiello L., Fontanini G., D'Agostini F., De Flora S., Noonan D.M., Albini A. N-Acetylcysteine inhibits endothelial cell invasion and angiogenesis. Lab Invest. 79:1999;1151-1159.