Endothelial dysfunction and subdinical hypothyroidism: A brief review

Journal of Endocrinological Investigation

Volumn 35, Issue 1, 2012, Pages 96-103

  La Vignera, S ^a   Condorelli, R ^a   Vicari, E ^a   Calogero, A E ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Atherosclerosis; Endothelial dysfunction; Subclinical hypothyroidism

Indexed keywords

ANGIOTENSIN RECEPTOR; C REACTIVE PROTEIN; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE; THYROTROPIN; THYROXINE;

ATHEROSCLEROSIS; CHRONIC INFLAMMATION; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HORMONE SUBSTITUTION; HUMAN; RISK FACTOR; SHORT SURVEY; SUBCLINICAL HYPOTHYROIDISM; THYROTROPIN BLOOD LEVEL; CARDIOVASCULAR DISEASE; HYPOTHYROIDISM; PATHOPHYSIOLOGY; REVIEW; VASCULAR ENDOTHELIUM;

CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; HUMANS; HYPOTHYROIDISM;

EID: 84861969570     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/8190     Document Type: Short Survey

References (35)

1. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 2001, 344: 501-9. (Pubitemid 32164903)
2. Kasahara T, Tsunekawa K, Seki K, Mori M, Murakami M. Regulation of iodothyronine deiodinase and roles of thyroid hormones in human coronary artery smooth muscle cells. Atherosclerosis 2006, 18: 207-14.
3. Klein I, Ojamaa K. Thyroid hormone: targeting the vascular smooth muscle cell. Circ Res 2001, 88: 260-1. (Pubitemid 32173746)
4. Ojamaa K, Klemperer JD, Klein I. Acute effects of thyroid hormone on vascular smooth muscle. Thyroid 1996, 6: 505-12. (Pubitemid 26398659)
5. Colantuoni A, Marchiafava PL, Lapi D, Forini FS, Iervasi G. Effects of tetraiodothyronine and triiodothyronine on hamster cheek pouch microcirculation. Am J Physiol Heart Circ Physiol 2005, 288: H1931-6. (Pubitemid 40418023)
6. Napoli R, Guardasole V, Angelini V, et al. Acute effects of triiodothyronine on endothelial function in human subjects. J Clin Endocrinol Metab 2007, 92: 250-4. (Pubitemid 46067540)
7. Quesada A, Sainz J, Wangensteen R, Rodriguez-Gomez I, Vargas F, Osuna A. Nitric oxide synthase activity in hyperthyroid and hypothyroid rats. Eur J Endocrinol 2002, 147: 117-22. (Pubitemid 34814748)
8. Mizuma H, Murakami M, Mori M. Thyroid hormone activation in human vascular smooth muscle cells: expression of type II iodothyronine deiodinase. Circ Res 2001, 88: 313-8. (Pubitemid 32173755)
9. Fukuyama K, Ichiki T, Takeda K, et al. Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone. Hypertension 2003, 41: 598-603. (Pubitemid 36314638)
10. Türemen EE, Çetinarslan B, Sahin T, Cantürk Z, Tarkun I. Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis. Endocr J 2011, 58: 349-54.
11. Alibaz Oner F, Yurdakul S, Oner E, Kubat Uzum A, Erguney M. Evaluation of the effect of L-thyroxin therapy on endothelial functions in patients with subdinical hypothyroidism. Endocrine 2011, 40: 280-4.
12. Lekakis J, Papamichael C, Alevizaki M, et al. Flow-mediated, endothelium-dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism, and high-normal serum thyrotropin (TSH) values. Thyroid 1997, 7: 411-4. (Pubitemid 27295140)
13. Shavdatuashvili T. Lipoprotein profile and endothelial function in patients with subclinical and overt hypothyroidism. Georgian Med News 2005, 129: 57-60.
14. Xiang GD, He YS, Zhao LS, Hou J, Yue L, Xiang HJ. Impairment of endothelium-dependent arterial dilation in Hashimoto's thyroiditis patients with euthyroidism. Clin Endocrinol (Oxf) 2006, 64: 698-702. (Pubitemid 43775010)
15. Biondi B, Galderisi M, Pagano L, et al. Endothelial-mediated coronary flow reserve in patients with mild thyroid hormone deficiency. Eur J Endocrinol 2009, 161: 323-9.
16. Yilmaz MI, Sonmez A, Karaman M et al. Low triiodothyronine alters flow-mediated vasodilatation in advanced nondiabetic kidney disease. Am J Nephrol 2011, 33: 25-32.
17. Taddei S, Caraccio N, Virdis A et al. Impaired endothelium-dependent vasodilatation in subdinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab 2003, 88: 3731-7. (Pubitemid 37034521)
18. Monzani F, Caraccio N, Kozàkowà M, et al. Effect of levothyroxine replacement on lipid profile and intima-media thickness in subdinical hypothyroidism: a double-blind, placebo- controlled study. J Clin Endocrinol Metab 2004, 89: 2099-106. (Pubitemid 38619837)
19. Guang-Da X, Hui-Ling S, Zhi-Song C, Lin-Shuang Z. Alteration of plasma concentrations of OPG before and after levothyroxine replacement therapy in hypothyroid patients. J Endocrinol Invest 2005, 28: 965-72. (Pubitemid 43265760)
20. Xiang GD, Sun HL, Zhao LS, Hou J, Yue L. Changes in plasma concentrations of osteoprotegerin before and after levothyroxine replacement therapy in hypothyroid patients. Zhonghua Yi Xue Za Zhi 2007, 87: 2121-5. (Pubitemid 350019946)
21. Akinci B, Comlekci A, Yener S et al. The alteration of serum soluble CD40 ligand levels in overt and subclinical hypothyroidism. Hormones (Athens) 2007, 6: 327-33.
22. Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab 2007, 92: 1715-23. (Pubitemid 46997177)
23. Dagre AG, Lekakis JP, Protogerou AD, et al. Abnormal endothelial function in female patients with hypothyroidism and borderline thyroid function. Int J Cardiol 2007, 114: 332-8. (Pubitemid 44855911)
24. Adrees M, Gibney J, El-Saeity N, Boran G. Effects of 18 months of L-T4 replacement in women with subclinical hypothyroidism. Clin Endocrinol (Oxf) 2009, 71: 298-303.
25. Kosar F, Sahin I, Turan N, Topal E, Aksoy Y, Taskapan C. Evaluation of right and left ventricular function using pulsed-wave tissue Doppler echocardiography in patients with subclinical hypothyroidism. J Endocrinol Invest 2005, 28: 704-10. (Pubitemid 43162855)
26. Owen PJ, Rajiv C, Vinereanu D, Mathew T, Fraser AG, Lazarus JH. Subclinical hypothyroidism, arterial stiffness, and myocardial reserve. J Clin Endocrinol Metab 2006, 91: 2126-32. (Pubitemid 43854994)
27. Oflaz H, Kurt R, Cimen A, et al. Coronary flow reserve is also impaired in patients with subclinical hypothyroidism. Int J Cardiol 2007, 120: 414-6. (Pubitemid 47069553)
28. Taddei S, Caraccio N, Virdis A, et al. Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis. J Clin Endocrinol Metab 2006, 91: 5076-82. (Pubitemid 44917353)
29. Xiang GD, Pu J, Sun H, Zhao L, Yue L, Hou J. Regular aerobic exercise training improves endothelium-dependent arterial dilation in patients with subclinical hypothyroidism. Eur J Endocrinol 2009, 161: 755-61.
30. Xiang GD, Pu JH, Sun HL, Zhao LS. Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism. Exp Clin Endocrinol Diabetes 2010, 118: 625-9.
31. Shakoor SK, Aldibbiat A, Ingoe LE, et al. Endothelial progenitor cells in subclinical hypothyroidism: the effect of thyroid hormone replacement therapy. J Clin Endocrinol Metab 2010, 95: 319-22.
32. Mariotti S, Cambuli VM. Cardiovascular risk in elderly hypothyroid patients. Thyroid 2007, 17: 1067-73. (Pubitemid 350207761)
33. Biondi B, Klein I. Hypothyroidism as a risk factor for cardiovascular disease. Endocrine 2004, 24: 1-13. (Pubitemid 41364165)
34. Duman D, Sahin S, Esertas K, Demirtunc R. Simvastatin improves endothelial function in patents with subclinical hypothyroidism. Heart Vessels 2007, 22: 88-93. (Pubitemid 46510547)
35. Cabrai MD, Teixeira PF, Silva NA et al. Normal flow-mediated vasodilatation of the brachial artery and carotid artery intima-media thickness in subclinical hypothyroidism. Braz J Med Biol Res 2009, 42: 426-32.