Cardiovascular risk in elderly hypothyroid patients

Thyroid

Volumn 17, Issue 11, 2007, Pages 1067-1073

  Mariotti, Stefano ^a,b   Cambuli, Valentina Maria ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b Policlinico Universitario di Monserrato   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HOMOCYSTEINE; LEVOTHYROXINE; OXYGEN;

AGE DISTRIBUTION; ATHEROGENESIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MALFORMATION; CARDIOVASCULAR RISK; DRUG DOSE INCREASE; ENDOTHELIAL DYSFUNCTION; EPIDEMIOLOGICAL DATA; GERIATRIC PATIENT; HUMAN; HYPOTHYROIDISM; ISCHEMIC HEART DISEASE; LOW DRUG DOSE; MIDDLE AGED; MORTALITY; OVERT HYPOTHYROIDISM; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVIEW; SUBCLINICAL HYPOTHYROIDISM;

AGED; AGED, 80 AND OVER; AGING; AUTOIMMUNE DISEASES; CARDIOVASCULAR DISEASES; CORONARY DISEASE; FEMALE; HUMANS; HYPOTHYROIDISM; MALE; MIDDLE AGED; RISK FACTORS; THYROID GLAND;

EID: 36749088882     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2007.0130     Document Type: Review

References (82)

1. Mariotti S, Franceschi C, Cossarizza A, Pinchera A 1995 The aging thyroid. Endocr Rev 16:686-715.
2. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC 2000 The Colorado thyroid disease prevalence study. Arch Intern Med 160:526-534.
3. Helfand M, Redfern CC 1998 Clinical Guideline, part 2. Screening for thyroid disease: an update. American College of Physicians. Ann Intern Med 129:144-158.
4. Campbell AJ, Reinken J, Allan BC 1981 Thyroid disease in the elderly in the community. Age Ageing 10:47-52.
5. Riniker M, Tièche M, Lupi GA, Grob P, Studer H, Burgi H 1981 Prevalence of various degrees of hypothyroidism among patients of a general medical department. Clin Endocrinol (Oxf) 14:69-74.
6. Livingston EH, Hershman JM, Sawin CT, Yoshikawa TT 1987 Prevalence of thyroid disease and abnormal thyroid tests in older hospitalized and ambulatory persons. J Am Geriatr Soc 35:109-114.
7. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE 2002 Serum TSH, T(4), and thyroid antibodies in the United States Population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489-499.
8. Robuschi G, Safran M, Braverman LE, Gnudi A, Roti E 1987 Hypothyroidism in the elderly. Endocr Rev 8:142-153.
9. Safran M, Paul TL, Roti E, Braverman LE 1987 Environmental factors affecting autoimmune thyroid disease. Endocrinol Metab Clin North Am 16:327-342.
10. Martino E, Bartalena L, Bogazzi F, Braverman LE 2001 The effects of amiodarone on the thyroid. Endocr Rev 22:240-254.
11. Morley JE 1995 Hormones, aging, and endocrine diseases. In: Felig P, Baxter JD, Frohman LA (eds) Endocrinology and Metabolism. 3rd ed. McGraw-Hill, New York, pp 1813-1836.
12. Melmed S, Hershman JM 1983 The thyroid and aging. In: Korenman SG (ed) Endocrine Aspects of Aging. Elsevier Biomedical, New York, pp 33-53.
13. Wartofsky L, Burman KD 1982 Alterations in thyroid function in patients with systemic illness: the "euthyroid sick syndrome." Endocr Rev 3:164-217.
14. van den Berghe G 2000 Novel insights into the neuroendocrinology of critical illness. Eur J Endocrinol 143:1-13.
15. Zondek H 1918 Das myxodemhertz. Munch Med Wochenschr 65:1180-1181.
16. Vora J, O'Malley P, Peterson S, McCullogh A, Rosenthal FD, Barnett DB 1985 Reversible abnormalities of myocardial relaxation in hypothyroidism. J Clin Endocrinol Metab 61:269-272.
17. Saito I, Saruta T 1994 Hypertension in thyroid disorders. Endocrinol Metab Clin North Am 23:379-386.
18. Graettinger JS, Muenster JJ, Checchia CS, Grisson RL, Campbell JA 1958 A correlation of clinical and hemodynamic studies in patients with hypothyroidism. J Clin Invest 9:502-510.
19. Obuobie K, Smith J, Evans LM, John R, Davies JS, Lazarus JH 2002 Increased arterial stiffness in hypothyroidism. J Clin Endocrinol Metab 87:4662-4666.
20. Klein I, Ojamaa K 2001 Thyroid hormone and the cardiovascular system. N Engl J Med 344:501-509.
21. Vanhaelst L, Neve P, Chailly P, Bastenie PA 1967 Coronary artery disease in hypothyroidism. Observations in clinical myxoedema. Lancet 2:800-802.
22. Cappola AR, Ladenson PW 2003 Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab 88:2438-2444.
23. O'Brien T, Dinneen SF, O'Brien PC, Palumbo PJ 1993 Hyperlipidemia in patients with primary and secondary hypothyroidism. Mayo Clin Proc 68:860-866.
24. Christ-Crain M, Meier C, Guglielmetti M, Huber PR, Riesen W, Staub JJ, Muller B 2003 Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial. Atherosclerosis 166:379-386.
25. Morris MS, Bostom AG, Jacques PF, Selhub J, Rosenberg IH 2001 Hyperhomocysteinemia and hypercholesterolemia associates with hypothyroidism in the third U.S. National Health and Nutrition Examination Survey. Atherosclerosis 155:195-200.
26. Lekakis J, Papamichael C, Alevizaki M, Piperingos G, Marafelia P, Mantzos J, Stamatelopoulos S, Koutras DA 1997 Flow-mediated, endothelium-dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism and high-normal serum thyrotropin (TSH) values. Thyroid 7:411-414.
27. Chadarevian R, Bruckert E, Leenhardt L, Giral P, Ankri A, Turpin G 2001 Components of the fibrinolytic system are differently altered in moderate and severe hypothyroidism. J Clin Endocrinol Metab 86:732-737.
28. Marongiu F, Cauli C, Mariotti S 2004 Thyroid, hemostasis and thrombosis. J Endocrinol Invest 27:1065-1071.
29. Roos A, Linn-Rasker SP, van Domburg RT, Tijssen JP, Berghout A 2005 The starting dose of levothyroxine in primary hypothyroidism treatment: a prospective, randomized, double-blind trial. Arch Intern Med 165:1714-1720.
30. Becker C 1985 Hypothyroidism and atherosclerotic heart disease: pathogenesis, medical management, and the role of coronary artery bypass surgery. Endocr Rev 6:432-440.
31. Levine HD 1980 Compromise therapy in the patient with angina pectoris and hypothyroidism. A clinical assessment. Am J Med 69:411-418.
32. Col NF, Surks MI, Daniels GH 2004 Subclinical thyroid disease: clinical applications. JAMA 291:239-243.
33. Helfand M 2004 Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 140:128-141.
34. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ 2004 Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 291:228-238.
35. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT 2005 Consensus Statement #1: Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. Thyroid 15:24-28; response 32-33.
36. Pinchera A 2005 Subclinical thyroid disease: to treat or not to treat? Thyroid 15:1-2.
37. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC 2000 Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 132:270-278.
38. Lindeman RD, Romero LJ, Schade DS, Wayne S, Baumgartner RN, Garry PJ 2003 Impact of subclinical hypothyroidism on serum total homocysteine concentrations, the prevalence of coronary heart disease (CHD) and CHD risk factors in the New Mexico Elder Health Survey. Thyroid 13:595-600.
39. Imaizumi M, Akahoshi M, Ichimaru S, Nakashima E, Hida A, Soda M, Usa T, Ashizawa K, Yokoyama N, Maeda R, Nagataki S, Eguchi K 2004 Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism. J Clin Endocrinol Metab 89:3365-3370.
40. Walsh JP, Bremner AL, Bulsara MK, O'Leary P, Leedman PJ, Feddema P, Michelangeli V 2005 Subclinical thyroid dysfunction as a risk factor for cardiovascular disease. Arch Intern Med 165:2467-2472.
41. Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J 2004 Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clin Endocrinol (Oxf) 61:232-238.
42. Parle JV, Maisonneuve P, Sheppard MC, Boyle P, Franklin JA 2001 Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet 358:861-865.
43. Rodondi N, Newman AB, Vittinghof E, de Rekeneire N, Satterfield S, Harris TB, Bauer DC 2005 Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med 165:2460-2466.
44. Cappola AR, Fried LP, Arnold AM, Danese MD, Kuller LH, Burke GL, Tracy RP, Ladenson PW 2006 Thyroid status, cardiovascular risk, and mortality in older adults. JAMA 295:1033-1041.
45. Rodondi N, Aujesky D, Vittinghoff E, Cornuz J, Bauer DC 2006 Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis. Am J Med 119:541-551.
46. Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frolich M, Westendorp RG 2004 Thyroid status, disability and cognitive function, and survival in old age. JAMA 292:2591-2599.
47. Parle JV, Franklin JA, Cross KW, Jones SR, Sheppard MC 1992 Circulating lipids and minor abnormalities of thyroid function. Clin Endocrinol (Oxf) 39:275-280.
48. Geul KW, van Sluiveld IL, Grobbee DE, Docter R, de Bruyn AM, Hooykaas H, van der Merwe JP, van Hemert AM, Krenning EP, Nennemann G, Weber RFA 1993 The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: associations with serum lipids. Clin Endocrinol (Oxf) 39:275-280.
49. Walsh JP, Bremner AL, Bulsara MK, O'Leary P, Leedman PJ, Feddema P, Michelangeli V 2005 Thyroid dysfunction and serum lipids: a community-based study. Clin Endocrinol (Oxf) 63:670-675.
50. Kanaya AM, Harris F, Volpato S, Perez-Stable EJ, Harris T, Bauer DC 2002 Association between thyroid dysfunction and total cholesterol level in an older biracial population: the health, aging and body composition study. Arch Intern Med 162:773-779.
51. Bogner U, Arntz HR, Peters H, Schleusener H 1993 Subclinical hypothyroidism and hyperlipoproteinemia: indiscriminate L-thyroxine treatment not justified. Acta Endocrinol (Copenh) 128:202-206.
52. Franklyn JA, Daykin J, Betteridge J, Hughes EA, Holder R, Jones SR, Sheppard MC 1993 Thyroxine replacement therapy and circulating lipid concentrations. Clin Endocrinol (Oxf) 38:453-459.
53. Miura S, Iitaka M, Yoshimura H, Kitahama S, Fukasawa N, Kawakami Y, Sakurai S, Urabe M, Sakatsume Y, Ito K, Ishii J 1994 Disturbed lipid metabolism in patients whit subclinical hypothyroidism: effect of L-thyroxine therapy. Internal Med 33:413-417.
54. Caraccio N, Ferranini E, Monzani F 2002 Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study. J Clin Endocrinol Metab 87:1533-1538.
55. Jaeschke R, Guyatt G, Gerstein H, Patterson C, Molloy W, Cook D, Harper S, Griffith L, Carbotte R 1996 Does treatment whit L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism? J Gen intern Med 11:744-749.
56. Kong WM, Sheikh MH, Lumb PJ, Freedman DB, Crook M, Dore CJ, Finer N 2002 A 6-month randomized trial of thyroxine treatment in women whit mild subclinical hypothyroidism. Am J Med 112:348-354.
57. Efstathiadou Z, Bitsis S, Milionis HJ, Kukuvitis A, Bairaktari ET, Elisaf MS, Tsatsoulis A 2001 Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial? Eur J Endocrinol 145:705-710.
58. Beyhan Z, Erturk K, Ucraya G, Bolu E, Yaman H, Kutlu M 2006 Restoration of euthyroidism does not improve cardiovascular risk factors in patients with subclinical hypothyroidism in the short term. J Endocrinol Invest 29:505-510.
59. Danese MD, Ladenson PW, Meinert CL, Powe NR 2000 Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J Clin Endocrinol Metab 85:2993-3001.
60. Luboshitzky R, Herer P 2004 Cardiovascular risk factors in middle-aged women with subclinical hypothyroidism. Neuro Endocrinol Lett 25:262-266.
61. Biondi B, Palmieri EA, Lombardi G, Fazio S 2002 Effects of subclinical thyroid dysfunction on the heart. Ann Intern Med 137:904-914.
62. Zoncu S, Pigliaru F, Putzu C, Pisano L, Vargiu S, Deidda M, Mariotti S, Mercuro G 2005 Cardiac function in borderline hypothyroidism: a study by pulsed wave tissue Doppler imaging. Eur J Endocrinol 152:527-533.
63. Hueston WJ, King DE, Geesey ME 2005 Serum biomarkers for cardiovascular inflammation in subclinical hypothyroidism. Clin Endocrinol (Oxf) 63:582-587.
64. Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, Ghiadoni L, Salvetti A, Ferranini E, Monzani F 2003 Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab 88:3731-3737.
65. Muller B, Tsakiris DA, Roth CB, Guglielmetti M, Staub JJ, Marbet GA 2001 Haemostatic profile in hypothyroidism as potential risk factor for vascular or thrombotic disease. Eur J Clin Invest 31:131-137.
66. Wick G, Schett G, Amberger A, Kleindienst R, Xu Q 1995 Is atherosclerosis an immunologically mediated disease? Immunol Today 16:27-33.
67. Palinski W, Tangirala RK, Miller E, Young SG, Witztum JL 1995 Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis. Arterioscler Thromb Vasc Biol 15:1569-1576.
68. Xu Q, Willeit J, Marosi M, Kleindienst R, Oberhollenzer F, Kiechl S, Stulnig T, Luef G, Wick G 1993 Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet 341:255-259.
69. Bastenie PA, Vanhaelst L, Neve P 1967 Coronary-artery disease in hypothyroidism. Lancet 2:1221-1222.
70. Bastenie PA, Vanhaelst L, Bonnyns M, Neve P, Staquet M 1971 Preclinical hypothyroidism: a risk factor for coronary heart-disease. Lancet 1::203-204.
71. Bastenie PA, Vanhaelst L, Golstein J, Smets P 1977 Asymptomatic autoimmune thyroiditis and coronary heart-disease. Cross-sectional and prospective studies. Lancet 2:155-158.
72. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, Grimley Evans J, Rodgers H, Tunbridge F, Young ET 1996 The development of ischemic heart disease in relation to autoimmune thyroid disease in a 20-year follow-up study of an English community. Thyroid 6:155-160.
73. Wells BJ, Hueston WJ 2005 Are thyroid antibodies associated with cardiovascular disease risk in patients with subclinical hypothyroidism? Clin Endocrinol (Oxf) 62:580-584.
74. Mariotti S, Barbesino G, Caturegli P, Bartalena S, Sansoni P, Fagnoni F, Monti D, Fagiolo U, Franchesci C, Pinchera A 1993 Complex alteration of thyroid function in healthy centenarians. J Clin Endocrinol Metab 77:1130-1134.
75. van den Beld AW, Visser TJ, Feelders RA, Grobbee DE, Lamberts SWJ 2005 Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 90:6403-6409.
76. Mariotti S 2005 Thyroid function and aging: do serum 3,5,3′- triiodothyronine and thyroid-stimulating hormone concentrations give the Janus response? J Clin Endocrinol Metab 90:6735-6737.
77. Mariotti S, Sansoni P, Barbesino G, Caturegli P, Monti D, Cossarizza A, Giacomelli T, Passeri G, Fagiolo U, Pinchera A, Franceschi C 1992 Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet 339:1506-1508.
78. Franceschi C, Monti D, Sansoni P, Cossarizza A 1995 The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 16:12-16.
79. Moulias R, Proust J, Wang A, Congy F, Marescot MR, Deville Chabrolle A, Paris Hamelin A, Lesourd B 1984 Age-related increase in autoantibodies. Lancet 1:1128-1129.
80. Szabolcs I, Bernard W, Horster FA 1995 Thyroid autoantibodies in hospitalised chronic geriatrics patients: prevalence, effect of age, nonthyroidal clinical state, and thyroid function. J Am Geriatr Soc 43:670-673.
81. Pinchera A, Mariotti S, Barbesino G, Bechi R, Sansoni P, Fagiolo U, Cossarizza A, Franceschi C 1995 Thyroid autoimmunity and ageing. Horm Res 43:64-68.
82. Mariotti S, Barbesino G, Chiovato L, Marino M, Pinchera A, Zuliani G, Mezzetti A, Fellin R 1999 Circulating thyroid autoantibodies in a sample of Italian octo-nonagenarians: relationship to age, sex, disability, and lipid profile. Aging (Milano) 11:362-366.