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Volumn 3, Issue 1, 2012, Pages 1-16

A review of exenatide: Optimizing glycemic control and associated cardiovascular risk factors in type 2 diabetes

Author keywords

Cardiovascular risk factors; Diabetes; Exenatide; Extended release; GLP 1 analog; Glycemic control; Hypoglycemia; Incretin mimetics; Type 2 diabetes obesity

Indexed keywords

ALOGLIPTIN; BIPHASIC INSULIN; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLITAZONE DERIVATIVE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INCRETIN; INSULIN; INSULIN ASPART; INSULIN GLARGINE; LINAGLIPTIN; LIRAGLUTIDE; LONG ACTING DRUG; LONG ACTING INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; ORAL ANTIDIABETIC AGENT; PIOGLITAZONE; PLACEBO; SAXAGLIPTIN; SHORT ACTING DRUG; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN;

EID: 84861916881     PISSN: 18696953     EISSN: 18696961     Source Type: Journal    
DOI: 10.1007/s13300-012-0003-x     Document Type: Review
Times cited : (5)

References (50)
  • 1
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87:4-14.
    • (2010) Diabetes Res Clin Pract , vol.87 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 2
    • 38949210220 scopus 로고    scopus 로고
    • Effect of a multifactorial intervention on mortality in type 2 diabetes
    • Gaede P, Lund-Andersen H, Parving HH, et al. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358:580-91.
    • (2008) N Engl J Med , vol.358 , pp. 580-591
    • Gaede, P.1    Lund-Andersen, H.2    Parving, H.H.3
  • 4
    • 64749100501 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan D, Buse J, Mayer B, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.1    Buse, J.2    Mayer, B.3
  • 5
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down?
    • Nauck M, Vardarli I, Deacon CF, et al. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia. 2011;54: 10-8.
    • (2011) Diabetologia , vol.54 , pp. 10-18
    • Nauck, M.1    Vardarli, I.2    Deacon, C.F.3
  • 6
    • 77955480007 scopus 로고    scopus 로고
    • Glucagonlike peptide-1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxidedependent mechanisms in conscious dogs with dilated cardiomyopathy
    • Bhashyam S, Fields AV, Paterson B, et al. Glucagonlike peptide-1 increases myocardial glucose uptake via p38alpha MAP kinase-mediated, nitric oxidedependent mechanisms in conscious dogs with dilated cardiomyopathy. Circ Heart Fail. 2010;3: 512-21.
    • (2010) Circ Heart Fail , vol.3 , pp. 512-521
    • Bhashyam, S.1    Fields, A.V.2    Paterson, B.3
  • 7
    • 33644909581 scopus 로고    scopus 로고
    • Heme oxygenase- 1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function
    • Liu X, Pachori AS, Ward CA, et al. Heme oxygenase- 1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function. FASEB J. 2006;20: 207-16.
    • (2006) FASEB J , vol.20 , pp. 207-216
    • Liu, X.1    Pachori, A.S.2    Ward, C.A.3
  • 8
    • 79951884751 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-based therapies and cardiovascular disease: Looking beyond glycaemic control
    • Anagnostis P, Athyros VG, Adamidou F, et al. Glucagon-like peptide-1-based therapies and cardiovascular disease: looking beyond glycaemic control. Diabetes Obes Metab. 2011;13:302-12.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 302-312
    • Anagnostis, P.1    Athyros, V.G.2    Adamidou, F.3
  • 9
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptordependent and -independent pathways
    • Ban K, Noyan-Ashraf MH, Hoefer J, et al. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptordependent and -independent pathways. Circulation. 2008;117:2340-50.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3
  • 10
    • 9944251347 scopus 로고    scopus 로고
    • Glucagonlike peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
    • Nyström T, Gonon AT, Sjöholm A, et al. Glucagonlike peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism. Regul Pept. 2005;125:173-7.
    • (2005) Regul Pept , vol.125 , pp. 173-177
    • Nyström, T.1    Gonon, A.T.2    Sjöholm, A.3
  • 11
    • 78650733949 scopus 로고    scopus 로고
    • Cardiovascular comorbidities of type 2 diabetes mellitus: Defining the potential of glucagon-like peptide-1-based therapies
    • Chilton R, Wyatt J, Nandish S, et al. Cardiovascular comorbidities of type 2 diabetes mellitus: defining the potential of glucagon-like peptide-1-based therapies. Am J Med. 2011;124:S35-53.
    • (2011) Am J Med , vol.124
    • Chilton, R.1    Wyatt, J.2    Nandish, S.3
  • 14
    • 18144401971 scopus 로고    scopus 로고
    • Effectsofexenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • De Fronzo RA, Ratner RE, Han J, et al. Effectsofexenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care. 2005;28:1092-100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • de Fronzo, R.A.1    Ratner, R.E.2    Han, J.3
  • 15
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han JJ, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. 2004;27:2628-35.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.J.3
  • 16
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care. 2005;28:1083-91.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3
  • 17
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L, Klein EJ, Han J, et al. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab. 2006;8:436-47.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3
  • 18
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff DC, Buse JB, Nielsen LL, et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin. 2008;24:275-86.
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3
  • 19
    • 34247259577 scopus 로고    scopus 로고
    • The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes
    • Zinman B, Hoogwerf BJ, Garcia SD, et al. The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes. Ann Intern Med. 2007;146:477-85.
    • (2007) Ann Intern Med , vol.146 , pp. 477-485
    • Zinman, B.1    Hoogwerf, B.J.2    Garcia, S.D.3
  • 20
    • 77958540163 scopus 로고    scopus 로고
    • A placebocontrolled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin
    • Liutkus J, Rosas GJ, Norwood P, et al. A placebocontrolled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin. Diabetes Obes Metab. 2010;12: 1058-65.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 1058-1065
    • Liutkus, J.1    Rosas, G.J.2    Norwood, P.3
  • 21
    • 55949121579 scopus 로고    scopus 로고
    • Addition of thiazolidinedione or exenatide to oral agents in type 2 diabetes: A meta-analysis
    • Pinelli NR, Cha R, Brown MB, et al. Addition of thiazolidinedione or exenatide to oral agents in type 2 diabetes: a meta-analysis. Ann Pharmacother. 2008;42:1541-51.
    • (2008) Ann Pharmacother , vol.42 , pp. 1541-1551
    • Pinelli, N.R.1    Cha, R.2    Brown, M.B.3
  • 22
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes
    • Heine RJ, Van Gaal LF, Johns D, et al. Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes. Ann Intern Med. 2005;143:559-69.
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.J.1    van Gaal, L.F.2    Johns, D.3
  • 23
    • 70450199755 scopus 로고    scopus 로고
    • Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: Results of the Helping Evaluate Exenatide in patients with diabetes compared with Long-Acting insulin (HEELA) study
    • Davies MJ, Donnelly R, Barnett AH, et al. Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: results of the Helping Evaluate Exenatide in patients with diabetes compared with Long-Acting insulin (HEELA) study. Diabetes Obes Metab. 2009;11:1153-62.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1153-1162
    • Davies, M.J.1    Donnelly, R.2    Barnett, A.H.3
  • 24
    • 65949122087 scopus 로고    scopus 로고
    • One year treatment with exenatide improves β-cell function, compared with insulin glargine, in metformin treated type 2 diabetic patients
    • Bunck M, Diamant M, Corner A, et al. One year treatment with exenatide improves β-cell function, compared with insulin glargine, in metformin treated type 2 diabetic patients. Diabetes Care. 2009;32:762-8.
    • (2009) Diabetes Care , vol.32 , pp. 762-768
    • Bunck, M.1    Diamant, M.2    Corner, A.3
  • 25
    • 37349008890 scopus 로고    scopus 로고
    • Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulphonylurea: A multinational, randomized, open-label, twoperiod, crossover noninferiority trial
    • Barnett AH, Burger J, Johns D, et al. Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulphonylurea: a multinational, randomized, open-label, twoperiod, crossover noninferiority trial. Clin Ther. 2007;29:2333-48.
    • (2007) Clin Ther , vol.29 , pp. 2333-2348
    • Barnett, A.H.1    Burger, J.2    Johns, D.3
  • 26
    • 34247195226 scopus 로고    scopus 로고
    • A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: A non-inferiority study
    • Nauck M, Duran S, Kim D, et al. A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study. Diabetologia. 2007;50:259-67.
    • (2007) Diabetologia , vol.50 , pp. 259-267
    • Nauck, M.1    Duran, S.2    Kim, D.3
  • 27
    • 85046980116 scopus 로고    scopus 로고
    • Use of twice daily exenatide in basal insulin-treated patients with type 2 diabetes. A randomised controlled trial
    • Buse JB, Bergenstel RM, Glass LC, et al. Use of twice daily exenatide in basal insulin-treated patients with type 2 diabetes. A randomised controlled trial. Ann Intern Med. 2011;154:1-10.
    • (2011) Ann Intern Med , vol.154 , pp. 1-10
    • Buse, J.B.1    Bergenstel, R.M.2    Glass, L.C.3
  • 28
    • 79959428521 scopus 로고    scopus 로고
    • Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit
    • Thong KY, Jose B, Sukumar N, et al. Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit. Diabetes Obes Metab. 2011;13:703-10.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 703-710
    • Thong, K.Y.1    Jose, B.2    Sukumar, N.3
  • 29
    • 68649099986 scopus 로고    scopus 로고
    • Exenatide added to insulin therapy: A retrospective review of clinical practice over 2 years in an academic endocrinology outpatient setting
    • Yoon NM, Cavaghan MK, Brunelle RL, et al. Exenatide added to insulin therapy: a retrospective review of clinical practice over 2 years in an academic endocrinology outpatient setting. Clin Ther. 2009;31:1511-23.
    • (2009) Clin Ther , vol.31 , pp. 1511-1523
    • Yoon, N.M.1    Cavaghan, M.K.2    Brunelle, R.L.3
  • 30
    • 48949098988 scopus 로고    scopus 로고
    • Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus
    • Sheffield CA, Kane MP, Busch RS, et al. Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus. Endocr Pract. 2008;14:285-92.
    • (2008) Endocr Pract , vol.14 , pp. 285-292
    • Sheffield, C.A.1    Kane, M.P.2    Busch, R.S.3
  • 31
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;274:39-47.
    • (2009) Lancet , vol.274 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 32
    • 0035432607 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment
    • Larsen J, Hylleberg B, Ng K, et al. Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment. Diabetes Care. 2001;24:1416-21.
    • (2001) Diabetes Care , vol.24 , pp. 1416-1421
    • Larsen, J.1    Hylleberg, B.2    Ng, K.3
  • 33
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K, et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet. 2008;372:1240-50.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 34
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct tometformin for treatment of type 2 diabetes (DURATION-2): A randomised trial
    • Bergenstal RM, Wysham C, MacConell L, et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct tometformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet. 2010;376:431-9.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3
  • 35
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): An open-label randomised trial
    • Diamant M, Goal LV, Stranks S, et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial. Lancet. 2010;375:2234-43.
    • (2010) Lancet , vol.375 , pp. 2234-2243
    • Diamant, M.1    Goal, L.V.2    Stranks, S.3
  • 36
    • 84859013614 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as a monotherapy in drug-nai{dotless}̈ve patients with type 2 diabetes (DURATION-4): A 26-week double-blind study
    • Russell-Jones D, Cuddihy RM, Hanefeld M, et al. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as a monotherapy in drug-nai{dotless}̈ve patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. Diabetes Care. 2012;35:252-8.
    • (2012) Diabetes Care , vol.35 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3
  • 37
    • 79955661908 scopus 로고    scopus 로고
    • DURATION-5: Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patientswith type 2 diabetes
    • Blevins T, Pullman J, Malloy J, et al. DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patientswith type 2 diabetes. J Clin EndocrinolMetab. 2011;96:1301-10.
    • (2011) J Clin EndocrinolMetab , vol.96 , pp. 1301-1310
    • Blevins, T.1    Pullman, J.2    Malloy, J.3
  • 38
    • 84857385645 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus liraglutide in subjects with type 2 diabetes (DURATION 6): A randomised, open-label study
    • Buse J, Nauck M, Frost T, et al. Efficacy and safety of exenatide once weekly versus liraglutide in subjects with type 2 diabetes (DURATION 6): a randomised, open-label study. Diabetologia. 2011;54:S38.
    • (2011) Diabetologia , vol.54
    • Buse, J.1    Nauck, M.2    Frost, T.3
  • 39
    • 77953828230 scopus 로고    scopus 로고
    • DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
    • Buse J, Drucker DJ, Taylor KL, et al. DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care. 2010;33:1255-61.
    • (2010) Diabetes Care , vol.33 , pp. 1255-1261
    • Buse, J.1    Drucker, D.J.2    Taylor, K.L.3
  • 40
    • 53749096863 scopus 로고    scopus 로고
    • 10-Year follow-up of intensive glucose control in type 2 diabetes
    • Holman RR, Paul SK, Bethel MA, et al. 10-Year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577-89.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3
  • 41
    • 45149131667 scopus 로고    scopus 로고
    • Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD). Effects of intensive glucose lowering in type 2 diabetes
    • The ACCORD study group
    • The ACCORD study group, Gerstein HC, Miller ME, et al. Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD). Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358:2545-59.
    • (2008) N Engl J Med , vol.358 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2
  • 42
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • The ADVANCE collaborative group
    • The ADVANCE collaborative group, Patel A, MacMahon S, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;48:2560-72.
    • (2008) N Engl J Med , vol.48 , pp. 2560-2572
    • Patel, A.1    Macmahon, S.2
  • 43
    • 0035675342 scopus 로고    scopus 로고
    • Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: The epidemiological evidence
    • Bonora E, Muggeo M. Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: the epidemiological evidence. Diabetologia. 2001;44:2107-14.
    • (2001) Diabetologia , vol.44 , pp. 2107-2114
    • Bonora, E.1    Muggeo, M.2
  • 44
    • 0033807248 scopus 로고    scopus 로고
    • Intentional weight loss and mortality among overweight individuals with diabetes
    • Williamson DF, Thompson TJ, Thun M, et al. Intentional weight loss and mortality among overweight individuals with diabetes. Diabetes Care. 2000;23:1499-504.
    • (2000) Diabetes Care , vol.23 , pp. 1499-1504
    • Williamson, D.F.1    Thompson, T.J.2    Thun, M.3
  • 45
    • 79951702236 scopus 로고    scopus 로고
    • Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the GLP-1 receptor agonist exenatide twice daily or other glucose-lowering therapies: A retrospective analysis of the LifeLinkTM database
    • Best JH, Hoogwerf BJ, Herman WH, et al. Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the GLP-1 receptor agonist exenatide twice daily or other glucose-lowering therapies: a retrospective analysis of the LifeLinkTM database. Diabetes Care. 2010;34:90-5.
    • (2010) Diabetes Care , vol.34 , pp. 90-95
    • Best, J.H.1    Hoogwerf, B.J.2    Herman, W.H.3
  • 46
    • 80052518181 scopus 로고    scopus 로고
    • Cardiovascular outcomes associated with a new once-weekly GLP-q receptor agonist vs. traditional therapies for type 2 diabetes: A simulation analysis
    • Peskin B, Shcheprov A, Boye K, et al. Cardiovascular outcomes associated with a new once-weekly GLP-q receptor agonist vs. traditional therapies for type 2 diabetes: a simulation analysis. Diabetes Obes Metab. 2011;13:921-7.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 921-927
    • Peskin, B.1    Shcheprov, A.2    Boye, K.3
  • 48
    • 59649122584 scopus 로고    scopus 로고
    • Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model
    • Hirata K, Kume S, Araki S, et al. Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model. Biochem Biophys Res Commun. 2009;380: 44-9.
    • (2009) Biochem Biophys Res Commun , vol.380 , pp. 44-49
    • Hirata, K.1    Kume, S.2    Araki, S.3
  • 49
    • 76749161358 scopus 로고    scopus 로고
    • Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes
    • Okerson T, Yan P, Stonehouse A, et al. Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes. Am J Hypertens. 2010;23: 334-9.
    • (2010) Am J Hypertens , vol.23 , pp. 334-339
    • Okerson, T.1    Yan, P.2    Stonehouse, A.3
  • 50
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review andmeta-analysis
    • Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review andmeta-analysis. JAMA. 2007;298:194-206.
    • (2007) JAMA , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.