메뉴 건너뛰기




Volumn 109, Issue 22, 2012, Pages 8635-8640

Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice

Author keywords

Functional genomics; RNA seq; Thermoregulation; Transcriptomics

Indexed keywords

BIOFUEL; FATTY ACID; MUSCLE ENZYME;

EID: 84861909700     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120523109     Document Type: Article
Times cited : (152)

References (66)
  • 1
    • 0022817617 scopus 로고
    • Heat loss from deer mice (Peromyscus): Evaluation of seasonal limits to thermoregulation
    • Conley KE, Porter WP (1986) Heat loss from deer mice (Peromyscus): Evaluation of seasonal limits to thermoregulation. J Exp Biol 126:249-269.
    • (1986) J Exp Biol , vol.126 , pp. 249-269
    • Conley, K.E.1    Porter, W.P.2
  • 2
    • 13444305420 scopus 로고    scopus 로고
    • Nonshivering thermogenesis capacity associated to mitochondrial DNA haplotypes and gender in the greater white-toothed shrew, Crocidura russula
    • DOI 10.1111/j.1365-294X.2004.02414.x
    • Fontanillas P, Dépraz A, Giorgi MS, Perrin N (2005) Nonshivering thermogenesis capacity associated to mitochondrial DNA haplotypes and gender in the greater white-toothed shrew, Crocidura russula. Mol Ecol 14:661-670. (Pubitemid 40210693)
    • (2005) Molecular Ecology , vol.14 , Issue.2 , pp. 661-670
    • Fontanillas, P.1    Depraz, A.2    Giorgi, M.S.3    Perrin, N.4
  • 3
    • 0032880602 scopus 로고    scopus 로고
    • Natural selection on thermogenic capacity of high-altitude deer mice
    • Hayes JP, O'Connor CS (1999) Natural selection on therogenic capacity of high-altitude deer mice. Evolution 53:1280-1287. (Pubitemid 29416968)
    • (1999) Evolution , vol.53 , Issue.4 , pp. 1280-1287
    • Hayes, J.P.1    O'Connor, C.S.2
  • 5
    • 0000919037 scopus 로고
    • Effects of cold acclimation on maximum oxygen consumption during cold exposure and treadmill exercise in deer mice, Peromyscus maniculatus
    • Hayes JP, Chappell MA (1986) Effects of cold acclimation on maximum oxygen consumption during cold exposure and treadmill exercise in deer mice, Peromyscus maniculatus. Physiol Zool 59:473-481.
    • (1986) Physiol Zool , vol.59 , pp. 473-481
    • Hayes, J.P.1    Chappell, M.A.2
  • 6
    • 0016155336 scopus 로고
    • Maximum oxygen consumption and heat loss facilitation in small homeotherms by He-O2
    • Rosenmann M, Morrison P (1974) Maximum oxygen consumption and heat loss facilitation in small homeotherms by He-O2. Am J Physiol 226:490-495.
    • (1974) Am J Physiol , vol.226 , pp. 490-495
    • Rosenmann, M.1    Morrison, P.2
  • 8
    • 34249816617 scopus 로고    scopus 로고
    • Into thin air: Physiology and evolution of alpine insects
    • Dillon ME, Frazier MR, Dudley R (2006) Into thin air: Physiology and evolution of alpine insects. Integr Comp Biol 46:49-61.
    • (2006) Integr Comp Biol , vol.46 , pp. 49-61
    • Dillon, M.E.1    Frazier, M.R.2    Dudley, R.3
  • 9
    • 52149112510 scopus 로고    scopus 로고
    • Contribution of shivering and nonshivering thermogenesis to thermogenic capacity for the deer mouse (Peromyscus maniculatus)
    • Van Sant MJ, Hammond KA (2008) Contribution of shivering and nonshivering thermogenesis to thermogenic capacity for the deer mouse (Peromyscus maniculatus). Physiol Biochem Zool 81:605-611.
    • (2008) Physiol Biochem Zool , vol.81 , pp. 605-611
    • Van Sant, M.J.1    Hammond, K.A.2
  • 10
    • 78651335627 scopus 로고    scopus 로고
    • Metabolic fuels: Regulating fluxes to select mix
    • Weber J-M (2011) Metabolic fuels: Regulating fluxes to select mix. J Exp Biol 214: 286-294.
    • (2011) J Exp Biol , vol.214 , pp. 286-294
    • Weber, J.-M.1
  • 11
    • 0025975736 scopus 로고
    • Increased dependence on blood glucose after acclimatization to 4,300 m
    • Brooks GA, et al. (1991) Increased dependence on blood glucose after acclimatization to 4,300 m. J Appl Physiol 70:919-927.
    • (1991) J Appl Physiol , vol.70 , pp. 919-927
    • Brooks, G.A.1
  • 12
    • 0026769312 scopus 로고
    • Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m
    • Brooks GA, et al. (1992) Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m. J Appl Physiol 72: 2435-2445.
    • (1992) J Appl Physiol , vol.72 , pp. 2435-2445
    • Brooks, G.A.1
  • 13
    • 0032053158 scopus 로고    scopus 로고
    • Mechanism and evolution of hypoxia-tolerance in humans
    • Hochachka PW (1998) Mechanism and evolution of hypoxia-tolerance in humans. J Exp Biol 201:1243-1254.
    • (1998) J Exp Biol , vol.201 , pp. 1243-1254
    • Hochachka, P.W.1
  • 14
    • 0025906416 scopus 로고
    • Metabolic and work efficiencies during exercise in Andean natives
    • Hochachka PW, et al. (1991) Metabolic and work efficiencies during exercise in Andean natives. J Appl Physiol 70:1720-1730.
    • (1991) J Appl Physiol , vol.70 , pp. 1720-1730
    • Hochachka, P.W.1
  • 15
    • 8444244146 scopus 로고    scopus 로고
    • Fat to the fire: The regulation of lipid oxidation with exercise and environmental stress
    • McClelland GB (2004) Fat to the fire: The regulation of lipid oxidation with exercise and environmental stress. Comp Biochem Physiol B Biochem Mol Biol 139:443-460.
    • (2004) Comp Biochem Physiol B Biochem Mol Biol , vol.139 , pp. 443-460
    • McClelland, G.B.1
  • 16
    • 84947648641 scopus 로고
    • Increased capacity for circulatory fatty acid transport in a highly aerobic mammal
    • McClelland GB, Zwingelstein G, Taylor CR, Weber J-M (1994) Increased capacity for circulatory fatty acid transport in a highly aerobic mammal. Am J Physiol 266: R1280-R1286.
    • (1994) Am J Physiol , vol.266
    • McClelland, G.B.1    Zwingelstein, G.2    Taylor, C.R.3    Weber, J.-M.4
  • 17
    • 22844434241 scopus 로고    scopus 로고
    • Fuel selection in shivering humans
    • DOI 10.1111/j.1365-201X.2005.01465.x
    • Weber J-M, Haman F (2005) Fuel selection in shivering humans. Acta Physiol Scand 184:319-329. (Pubitemid 41039737)
    • (2005) Acta Physiologica Scandinavica , vol.184 , Issue.4 , pp. 319-329
    • Weber, J.-M.1    Haman, F.2
  • 18
    • 69949093555 scopus 로고    scopus 로고
    • Fuel selection in Wistar rats exposed to cold: Shivering thermogenesis diverts fatty acids from re-esterification to oxidation
    • Vaillancourt E, Haman F, Weber J-M (2009) Fuel selection in Wistar rats exposed to cold: Shivering thermogenesis diverts fatty acids from re-esterification to oxidation. J Physiol 587:4349-4359.
    • (2009) J Physiol , vol.587 , pp. 4349-4359
    • Vaillancourt, E.1    Haman, F.2    Weber, J.-M.3
  • 19
    • 0001501462 scopus 로고
    • Hemoglobin polymorphisms in deer mice (Peromyscus maniculatus), physiology of beta-globin variants and alpha-globin recombinants
    • Chappell MA, Hayes JP, Snyder LRG (1988) Hemoglobin polymorphisms in deer mice (Peromyscus maniculatus), physiology of beta-globin variants and alpha-globin recombinants. Evolution 42:681-688.
    • (1988) Evolution , vol.42 , pp. 681-688
    • Chappell, M.A.1    Hayes, J.P.2    Snyder, L.R.G.3
  • 20
    • 0021489105 scopus 로고
    • Biochemical and physiological correlates of deer mouse alpha-chain hemoglobin polymorphisms
    • Chappell MA, Snyder LRG (1984) Biochemical and physiological correlates of deer mouse alpha-chain hemoglobin polymorphisms. Proc Natl Acad Sci USA 81: 5484-5488.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 5484-5488
    • Chappell, M.A.1    Snyder, L.R.G.2
  • 22
    • 0033197692 scopus 로고    scopus 로고
    • Morphological and physiological responses to altitude in deer mice Peromyscus maniculatus
    • Hammond KA, Roth J, Janes DN, Dohm MR (1999) Morphological and physiological responses to altitude in deer mice Peromyscus maniculatus. Physiol Biochem Zool 72: 613-622.
    • (1999) Physiol Biochem Zool , vol.72 , pp. 613-622
    • Hammond, K.A.1    Roth, J.2    Janes, D.N.3    Dohm, M.R.4
  • 23
    • 0035746204 scopus 로고    scopus 로고
    • Effects of altitude and temperature on organ phenotypic plasticity along an altitudinal gradient
    • Hammond KA, Szewczak J, Król E (2001) Effects of altitude and temperature on organ phenotypic plasticity along an altitudinal gradient. J Exp Biol 204:1991-2000. (Pubitemid 34869516)
    • (2001) Journal of Experimental Biology , vol.204 , Issue.11 , pp. 1991-2000
    • Hammond, K.A.1    Szewczak, J.2    Krol, E.3
  • 24
    • 0024944417 scopus 로고
    • Field and maximal metabolic rates of deer mice (Peromyscus maniculatus) at low and high altitudes
    • Hayes JP (1989) Field and maximal metabolic rates of deer mice (Peromyscus maniculatus) at low and high altitudes. Physiol Zool 62:732-744.
    • (1989) Physiol Zool , vol.62 , pp. 732-744
    • Hayes, J.P.1
  • 25
    • 0024350304 scopus 로고
    • Altitudinal and seasonal effects on aerobic metabolism of deer mice
    • Hayes JP (1989) Altitudinal and seasonal effects on aerobic metabolism of deer mice. J Comp Physiol B 159:453-459.
    • (1989) J Comp Physiol B , vol.159 , pp. 453-459
    • Hayes, J.P.1
  • 26
    • 0035197250 scopus 로고    scopus 로고
    • Muscle adaptation to altitude: Tissue capillarity and capacity for aerobic metabolism
    • Mathieu-Costello O (2001) Muscle adaptation to altitude: Tissue capillarity and capacity for aerobic metabolism. High Alt Med Biol 2:413-425.
    • (2001) High Alt Med Biol , vol.2 , pp. 413-425
    • Mathieu-Costello, O.1
  • 27
    • 0001656948 scopus 로고
    • Deer mouse hemoglobins: Is there genetic adaptation to high altitude?
    • Snyder LRG (1981) Deer mouse hemoglobins: Is there genetic adaptation to high altitude? Bioscience 31:299-304.
    • (1981) Bioscience , vol.31 , pp. 299-304
    • Snyder, L.R.G.1
  • 28
    • 0024200414 scopus 로고
    • Alpha-chain hemoglobin polymorphisms are correlated with altitude in the deer mouse Peromyscus maniculatus
    • Snyder LRG, Hayes JP, Chappell MA (1988) Alpha-chain hemoglobin polymorphisms are correlated with altitude in the deer mouse, Peromyscus maniculatus. Evolution 42: 689-697. (Pubitemid 19324193)
    • (1988) Evolution , vol.42 , Issue.4 , pp. 689-697
    • Synder, L.R.G.1    Hayes, J.P.2    Chappell, M.A.3
  • 29
    • 77954843627 scopus 로고    scopus 로고
    • Genetic differences in hemoglobin function between highland and lowland deer mice
    • Storz JF, Runck AM, Moriyama H, Weber RE, Fago A (2010) Genetic differences in hemoglobin function between highland and lowland deer mice. J Exp Biol 213: 2565-2574.
    • (2010) J Exp Biol , vol.213 , pp. 2565-2574
    • Storz, J.F.1    Runck, A.M.2    Moriyama, H.3    Weber, R.E.4    Fago, A.5
  • 30
    • 70149102931 scopus 로고    scopus 로고
    • Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin
    • Storz JF, et al. (2009) Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin. Proc Natl Acad Sci USA 106:14450-14455.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14450-14455
    • Storz, J.F.1
  • 31
    • 33847668843 scopus 로고    scopus 로고
    • Hemoglobin function and physiological adaptation to hypoxia in high-altitude mammals
    • Storz JF (2007) Hemoglobin function and physiological adaptation to hypoxia in high-altitude mammals. J Mammal 88:24-31.
    • (2007) J Mammal , vol.88 , pp. 24-31
    • Storz, J.F.1
  • 32
    • 38949166751 scopus 로고    scopus 로고
    • Development partly determines the aerobic performance of adult deer mice, Peromyscus maniculatus
    • DOI 10.1242/jeb.012658
    • Russell GA, Rezende EL, Hammond KA (2008) Development partly determines the aerobic performance of adult deer mice, Peromyscus maniculatus. J Exp Biol 211: 35-41. (Pubitemid 351212188)
    • (2008) Journal of Experimental Biology , vol.211 , Issue.1 , pp. 35-41
    • Russell, G.A.1    Rezende, E.L.2    Hammond, K.A.3
  • 34
    • 1642423541 scopus 로고    scopus 로고
    • Cold-acclimation in Peromyscus: Temporal effects and individual variation in maximum metabolism and ventilatory traits
    • DOI 10.1242/jeb.00760
    • Rezende EL, Chappell MA, Hammond KA (2004) Cold-acclimation in Peromyscus: Temporal effects and individual variation in maximum metabolism and ventilatory traits. J Exp Biol 207:295-305. (Pubitemid 38106733)
    • (2004) Journal of Experimental Biology , vol.207 , Issue.2 , pp. 295-305
    • Rezende, E.L.1    Chappell, M.A.2    Hammond, K.A.3
  • 36
    • 0020576146 scopus 로고
    • Calculation of substrate oxidation rates in vivo from gaseous exchange
    • Frayn KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634.
    • (1983) J Appl Physiol , vol.55 , pp. 628-634
    • Frayn, K.N.1
  • 39
    • 26844542817 scopus 로고    scopus 로고
    • Roles of hierarchical and metabolic regulation in the allometric scaling of metabolism in Panamanian orchid bees
    • DOI 10.1242/jeb.01778
    • Suarez RK, Darveau C-A, Hochachka PW (2005) Roles of hierarchical and metabolic regulation in the allometric scaling of metabolism in Panamanian orchid bees. J Exp Biol 208:3603-3607. (Pubitemid 41463280)
    • (2005) Journal of Experimental Biology , vol.208 , Issue.18 , pp. 3603-3607
    • Suarez, R.K.1    Darveau, C.-A.2    Hochachka, P.W.3
  • 40
    • 0035999672 scopus 로고    scopus 로고
    • Analysis of mRNA expression and protein abundance data: An approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts
    • Greenbaum D, Jansen R, Gerstein M (2002) Analysis of mRNA expression and protein abundance data: An approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts. Bioinformatics 18:585-596. (Pubitemid 34525064)
    • (2002) Bioinformatics , vol.18 , Issue.4 , pp. 585-596
    • Greenbaum, D.1    Jansen, R.2    Gerstein, M.3
  • 41
    • 71149108056 scopus 로고    scopus 로고
    • Correlation of mRNA and protein in complex biological samples
    • Maier T, Güell M, Serrano L (2009) Correlation of mRNA and protein in complex biological samples. FEBS Lett 583:3966-3973.
    • (2009) FEBS Lett , vol.583 , pp. 3966-3973
    • Maier, T.1    Güell, M.2    Serrano, L.3
  • 42
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M (2009) RNA-Seq: A revolutionary tool for transcriptomics. Nat Rev Genet 10:57-63.
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 43
    • 22144440528 scopus 로고    scopus 로고
    • Toward a neutral evolutionary model of gene expression
    • DOI 10.1534/genetics.104.037135
    • Khaitovich P, Pääbo S, Weiss G (2005) Toward a neutral evolutionary model of gene expression. Genetics 170:929-939. (Pubitemid 40980692)
    • (2005) Genetics , vol.170 , Issue.2 , pp. 929-939
    • Khaitovich, P.1    Paabo, S.2    Weiss, G.3
  • 44
    • 33645754491 scopus 로고    scopus 로고
    • Neutral and adaptive variation in gene expression
    • Whitehead A, Crawford DL (2006) Neutral and adaptive variation in gene expression. Proc Natl Acad Sci USA 103:5425-5430.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5425-5430
    • Whitehead, A.1    Crawford, D.L.2
  • 45
    • 0022761823 scopus 로고
    • Maximum catalytic activity of some key enzymes in provision of physiologically useful information about metabolic fluxes
    • Newsholme EA, Crabtree B (1986) Maximum catalytic activity of some key enzymes in provision of physiologically useful information about metabolic fluxes. J Exp Zool 239: 159-167.
    • (1986) J Exp Zool , vol.239 , pp. 159-167
    • Newsholme, E.A.1    Crabtree, B.2
  • 50
    • 0029151795 scopus 로고
    • Enhanced cardiac metabolism of plasma glucose in high-altitude natives: Adaptation against chronic hypoxia
    • Holden JE, et al. (1995) Enhanced cardiac metabolism of plasma glucose in high-altitude natives: Adaptation against chronic hypoxia. J Appl Physiol 79:222-228.
    • (1995) J Appl Physiol , vol.79 , pp. 222-228
    • Holden, J.E.1
  • 51
    • 0029665283 scopus 로고    scopus 로고
    • 31P magnetic resonance spectroscopy of the Sherpa heart: A phosphocreatine/adenosine triphosphate signature of metabolic defense against hypobaric hypoxia
    • Hochachka PW, et al. (1996) 31P magnetic resonance spectroscopy of the Sherpa heart: A phosphocreatine/adenosine triphosphate signature of metabolic defense against hypobaric hypoxia. Proc Natl Acad Sci USA 93:1215-1220.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1215-1220
    • Hochachka, P.W.1
  • 52
    • 0028025422 scopus 로고
    • Higher exercise performance and lower VO2max in Tibetan than Han residents at 4,700 m altitude
    • Ge RL, et al. (1994) Higher exercise performance and lower VO2max in Tibetan than Han residents at 4,700 m altitude. J Appl Physiol 77:684-691.
    • (1994) J Appl Physiol , vol.77 , pp. 684-691
    • Ge, R.L.1
  • 54
    • 78650071722 scopus 로고    scopus 로고
    • Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates
    • Storz JF, Scott GR, Cheviron ZA (2010) Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates. J Exp Biol 213:4125-4136.
    • (2010) J Exp Biol , vol.213 , pp. 4125-4136
    • Storz, J.F.1    Scott, G.R.2    Cheviron, Z.A.3
  • 55
    • 33745179545 scopus 로고    scopus 로고
    • An automatic activity-monitoring system for small mammals under natural conditions
    • DOI 10.1644/05-MAMM-A-220R2.1
    • Rehmeier RL, Kaufman GA, Kaufman DW (2006) An automatic activity-monitoring system for small mammals under natural conditions. J Mammal 87:628-634. (Pubitemid 43902260)
    • (2006) Journal of Mammalogy , vol.87 , Issue.3 , pp. 628-634
    • Rehmeier, R.L.1    Kaufman, G.A.2    Kaufman, D.W.3
  • 56
    • 33645225818 scopus 로고    scopus 로고
    • Individual variation in thermogenic capcity affects above-ground activity of high-altitude deer mice
    • Sears MW, Hayes JP, O'Connor CS, Geluso K, Sedinger JS (2006) Individual variation in thermogenic capcity affects above-ground activity of high-altitude deer mice. Funct Ecol 20:97-104.
    • (2006) Funct Ecol , vol.20 , pp. 97-104
    • Sears, M.W.1    Hayes, J.P.2    O'Connor, C.S.3    Geluso, K.4    Sedinger, J.S.5
  • 57
    • 0031846994 scopus 로고    scopus 로고
    • Utilization of skeletal muscle triacylglycerol during post-exercise recovery in humans
    • Kiens B, Richter EA (1998) Utilization of skeletal muscle triacylglycerol during post-exercise recovery in humans. Am J Physiol 275:E332-E337.
    • (1998) Am J Physiol , vol.275
    • Kiens, B.1    Richter, E.A.2
  • 59
    • 0025830045 scopus 로고
    • Importance of fat as a support nutrient for energy: Metabolism of athletes
    • Bjorntorp P (1991) Importance of fat as a support nutrient for energy: Metabolism of athletes. J Sports Sci 9(Spec No):71-76.
    • (1991) J Sports Sci , vol.9 , Issue.SPEC NO , pp. 71-76
    • Bjorntorp, P.1
  • 60
    • 33745715519 scopus 로고    scopus 로고
    • Skeletal muscle adaptation to endurance training
    • eds MacLeod D, et al. E and FN Spon, London
    • Henriksson J, Hickner R (1996) Skeletal muscle adaptation to endurance training. Intermittent High Intensity Excercise, eds MacLeod D, et al. (E and FN Spon, London).
    • (1996) Intermittent High Intensity Excercise
    • Henriksson, J.1    Hickner, R.2
  • 61
    • 34047218882 scopus 로고    scopus 로고
    • The molecular basis of high-altitude adaptation in deer mice
    • Storz JF, et al. (2007) The molecular basis of high-altitude adaptation in deer mice. PLoS Genet 3:e45.
    • (2007) PLoS Genet , vol.3
    • Storz, J.F.1
  • 62
    • 34249651787 scopus 로고    scopus 로고
    • Evolvability of physiological and biochemical traits: Evolutionary mechanisms including and beyond single-nucleotide mutation
    • Feder ME (2007) Evolvability of physiological and biochemical traits: Evolutionary mechanisms including and beyond single-nucleotide mutation. J Exp Biol 210: 1653-1660.
    • (2007) J Exp Biol , vol.210 , pp. 1653-1660
    • Feder, M.E.1
  • 63
    • 46249106990 scopus 로고    scopus 로고
    • Mapping and quantifying mammalian transcriptomes by RNA-Seq
    • DOI 10.1038/nmeth.1226, PII NMETH.1226
    • Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5:621-628. (Pubitemid 351911867)
    • (2008) Nature Methods , vol.5 , Issue.7 , pp. 621-628
    • Mortazavi, A.1    Williams, B.A.2    McCue, K.3    Schaeffer, L.4    Wold, B.5
  • 64
    • 79551587720 scopus 로고    scopus 로고
    • Cytoscape 2.8: New features for data integration and network visualization
    • Smoot ME, Ono K, Ruscheinski J, Wang P-L, Ideker T (2011) Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics 27:431-432.
    • (2011) Bioinformatics , vol.27 , pp. 431-432
    • Smoot, M.E.1    Ono, K.2    Ruscheinski, J.3    Wang, P.-L.4    Ideker, T.5
  • 65
    • 38449101120 scopus 로고    scopus 로고
    • Integration of biological networks and gene expression data using Cytoscape
    • Cline MS, et al. (2007) Integration of biological networks and gene expression data using Cytoscape. Nat Protoc 2:2366-2382.
    • (2007) Nat Protoc , vol.2 , pp. 2366-2382
    • Cline, M.S.1
  • 66
    • 84946031884 scopus 로고
    • Procedures for identifying outlying observations in samples
    • Grubbs FE (1969) Procedures for identifying outlying observations in samples. Technometrics 11:1-21.
    • (1969) Technometrics , vol.11 , pp. 1-21
    • Grubbs, F.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.