Fuel selection in Wistar rats exposed to cold: Shivering thermogenesis diverts fatty acids from re-esterification to oxidation

Journal of Physiology

Volumn 587, Issue 17, 2009, Pages 4349-4359

  Vaillancourt, Eric ^a   Haman, François ^a   Weber, Jean Michel ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FATTY ACID; OLEIC ACID; PALMITIC ACID; LIPID; MONOUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ARTICLE; CALORIMETRY; COLD EXPOSURE; CONTROLLED STUDY; ESTERIFICATION; FATTY ACID OXIDATION; MALE; METABOLIC RATE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SHIVERING; THERMOGENESIS; WISTAR RAT; ANIMAL TISSUE; FATTY ACID ANALYSIS; FATTY ACID METABOLISM; FATTY ACID TRANSPORT; FUEL OXIDATION; GAS EXCHANGE; METABOLIC FUEL SELECTION; MOLECULAR DYNAMICS; OXIDATION; PHYSICAL PHENOMENA; REESTERIFICATION; SHIVERING THERMOGENESIS; STEADY STATE;

ACCLIMATIZATION; ANIMALS; CHOICE BEHAVIOR; COLD TEMPERATURE; EATING; ESTERIFICATION; FATTY ACIDS; FEEDING BEHAVIOR; HEAT-SHOCK RESPONSE; MALE; OXIDATION-REDUCTION; RATS; RATS, WISTAR; SHIVERING;

EID: 69949093555     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2009.175331     Document Type: Article

References (47)

1. Abdul-Malak N, Brichon G, Meister R & Zwingelstein G (1989). Environmental temperature and metabolism of molecular species of phosphatidylcholine in the tissues of the rainbow trout. Lipids 24, 318-324.
2. Adán C, Ardévol A, Remesar X, Alemany M & Fernández-López JA (1995). Hindleg muscle energy and substrate balances in cold-exposed rats. J Exp Biol 198, 1243-1251.
3. Arola L, Herrera E & Alemany M (1979). A method for the estimation of striated muscle mass in small laboratory animals. Rev Esp Fisiol 35, 215-218.
4. Banet M, Hensel H & Liebermann H (1978). The central control of shivering and non-shivering thermogenesis in the rat. J Physiol 283, 569-584.
5. Blem CR (1990). Avian energy storage. Curr Ornithol 7, 59-113.
6. Cannon B & Nedergaard J (2004). Brown adipose tissue: Function and physiological significance. Physiol Rev 84, 277-359.
7. Daenzer M, Petzke KJ, Bequette BJ & Metges CC (2001). Whole-body nitrogen and splanchnic amino acid metabolism differ in rats fed mixed diets containing casein or its corresponding amino acid mixture. J Nutr 131, 1965-1972.
8. Drummond GB (2009). Reporting ethical matters in The Journal of Physiology: Standards and advice. J Physiol 587, 713-719.
9. Florant GL, Nuttle LC, Mullinex DE & Rintoul DA (1990). Plasma and white adipose tissue lipid composition in marmots. Am J Physiol Regul Integr Comp Physiol 258, R1123-R1131.
10. Folch J, Lees M & Sloane-Stanley GH (1957). A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497-509.
11. Frayn KN (1983). Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55, 628-634.
12. Friedlander AL, Casazza GA, Horning MA, Usaj A & Brooks GA (1999). Endurance training increases fatty acid turnover, but not fat oxidation, in young men. J Appl Physiol 86, 2097-2105.
13. Friman G, Ilbäck N-G, Crawford DJ & Neufeld HA (1991). Metabolic responses to swimming exercise in Streptococcus pneumoniae infected rats. Med Sci Sports Exerc 23, 415-421.
14. Fuller CA, Horwitz BA & Horowitz JM (1975). Shivering and nonshivering thermogenic responses of cold-exposed rats to hypothalamic warming. Am J Physiol 228, 1519-1524.
15. Gautier H (2000). Body temperature regulation in the rat. J Therm Biol 25, 273-279.
16. Gautier H, Bonora M, Ben M, Barek S & Sinclair JD (1991). Effects of hypoxia and cold acclimation on thermoregulation in the rat. J Appl Physiol 71, 1355-1363.
17. Haman F, Legault SR, Rakobowchuk M, Ducharme MB & Weber J-M (2004a). Effects of carbohydrate availability on sustained shivering: II. Relating muscle recruitment to fuel selection. J Appl Physiol 96, 41-49.
18. Haman F, Legault SR & Weber J-M (2004b). Fuel selection during intense shivering in humans: EMG pattern reflects carbohydrate oxidation. J Physiol 556, 305-313.
19. Haman F, Péronnet F, Kenny G, Doucet E, Massicotte D, Lavoie C & Weber J-M (2004c). Effects of carbohydrate availability on sustained shivering: I. Oxidation of plasma glucose, muscle glycogen and proteins. J Appl Physiol 96, 32-40.
20. Haman F, Péronnet F, Kenny G, Massicotte D, Lavoie C, Scott C & Weber J-M (2002). Effect of cold exposure on fuel utilization in humans: Plasma glucose, muscle glycogen and lipids. J Appl Physiol 93, 77-84.
21. Haman F, Péronnet F, Kenny GP, Massicotte D, Lavoie C & Weber J-M (2005). Partitioning oxidative fuels during cold exposure: Muscle glycogen becomes dominant as shivering intensifies. J Physiol 566, 247-256.
22. Himms-Hagen J (1996). Neural and hormonal responses to prolonged cold exposure. In Handbook of Physiology, section 4, vol. II, ed. Fregly MJ & Blatteis CM, pp. 439-480. Oxford University Press, New York.
23. Jacobs I, Martineau L & Vallerand AL (1994). Thermoregulatory thermogenesis in humans during cold stress. In Exercise Sport Science Review, ed. Holloszy JO, pp. 221-250. Williams and Wilkins, Baltimore.
24. Jezierska B, Hazel JR & Gerking SD (1982). Lipid mobilization during starvation in the rainbow trout Salmo gairdneri Richardson, with attention to fatty acids. J Fish Biol 21, 681-692.
25. Kalderon B, Mayorek N, Berry E, Zevit N & Bar-Tana J (2000). Fatty acid cycling in the fasting rat. Am J Physiol Endocrinol Metab 279, E221-E227.
26. 177Lu. J Nucl Med 45, 1260-1269.
27. Leyton J, Drury PJ & Crawford MA (1987). Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat. Br J Nutr 57, 383-393.
28. Lund ED & Sidell BD (1992). Neutral lipid compositions of Antarctic fish tissues may reflect use of fatty acyl substrates by catabolic systems. Mar Biol 112, 377-382.
29. McClelland GB, Hochachka PW, Reidy S & Weber J-M (2001). High-altitude acclimation increases the triacylglycerol/fatty acid cycle at rest and during exercise. Am J Physiol Endocrinol Metab 281, E537-E544.
30. McClelland GB, Hochachka PW & Weber J-M (1999). Effect of high-altitude acclimation on NEFA turnover and lipid utilization during exercise in rats. Am J Physiol Endocrinol Metab 277, E1095-E1102.
31. Oufara S, Barré H, Rouanet J-L & Chatonnet J (1987). Adaptation to extreme ambient temperatures in cold-acclimated gerbils and mice. Am J Physiol Regul Integr Comp Physiol 253, R39-R45.
32. Raclot T & Groscolas R (1993). Differential mobilization of white adipose tissue fatty acids according to chain length, unsaturation, and positional isomerism. J Lipid Res 34, 1515-1526.
33. Raclot T & Groscolas R (1995). Selective mobilization of adipose tissue fatty acids during energy depletion in the rat. J Lipid Res 36, 2164-2173.
34. Reidy SP & Weber J-M (2002). Accelerated substrate cycling: A new energy-wasting role for leptin in vivo. Am J Physiol Endocrinol Metab 282, E312-E317.
35. Sidell BD (1991). Physiological roles of high lipid content in tissues of Antarctic fish species. In Biology of Antarctic Fish, ed. di Prisco G, Maresca B & Tota B, pp. 220-231. Springer Verlag, New York.
36. Sidell BD, Crockett EL & Driedzic WR (1995). Antarctic fish tissues preferentially catabolize monoenoic fatty acids. J Exp Zool 271, 73-81.
37. Smith OLK & Davidson SB (1982). Shivering thermogenesis and glucose uptake by muscles of normal or diabetic rats. Am J Physiol Regul Integr Comp Physiol 242, R109-R115.
38. Steele R (1959). Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Med Sci 82, 420-430.
39. Vaillancourt E, Prud'Homme S, Haman F, Guglielmo CG & Weber J-M (2005). Energetics of a long-distance migrant shorebird (Philomachus pugnax) during cold exposure and running. J Exp Biol 208, 317-325.
40. Vaillancourt E & Weber J-M (2007). Lipid mobilization of long-distance migrant birds in vivo: The high lipolytic rate of ruff sandpipers is not stimulated during shivering. J Exp Biol 210, 1161-1169.
41. a and TG/FFA cycling in humans. Aviat Space Environ Med 70, 42-50.
42. Weber J-M, Brichon G, Zwingelstein G, McClelland G, Saucedo C, Weibel ER & Taylor CR (1996). Design of the oxygen and substrate pathways: IV. Partitioning energy provision from fatty acids. J Exp Biol 199, 1667-1674.
43. Weber J-M & Haman F (2005). Fuel selection in shivering humans. Acta Physiol Scand 184, 319-329.
44. Weber J-M & O'Connor T (2000). Energy metabolism of the Virginia opossum during fasting and exercise. J Exp Biol 203, 1365-1371.
45. Wolfe RR, Klein S, Carraro F & Weber J-M (1990). Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. Am J Physiol Endocrinol Metab 258, E382-E389.
46. Younes H, Demigné C, Behr S & Rémésy C (1995). Resistant starch exerts a lowering effect on plasma urea by enhancing urea N transfer into the large intestine. Nutr Res 15, 1199-1210.
47. Young AJ (1988). Human adaptation to cold. In Human Performance Physiology and Environmental Medicine at Terrestrial Extremes, ed. Pandolf KB, Sawka MN & Gonzalez RR, pp. 401-434. Cooper Publishing Group, Traverse City, MI, USA.