Outcomes of cardiac transplantation in septuagenarians

Journal of Heart and Lung Transplantation

Volumn 31, Issue 7, 2012, Pages 679-685

  Goldstein, Daniel J ^a   Bello, Ricardo ^a   Shin, Jooyoung J ^a   Stevens, Gerin ^a   Zolty, Ronald ^a   Maybaum, Simon ^a   D'Alessandro, David ^a  

^a MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

age limit; cardiac transplant; rejection; septuagenarians; survival

Indexed keywords

ADULT; AGED; ARTICLE; ARTIFICIAL HEART PACEMAKER; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CHI SQUARE TEST; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GERIATRIC PATIENT; GRAFT REJECTION; GRAFT SURVIVAL; HAZARD RATIO; HEART ASSIST DEVICE; HEART FAILURE; HEART TRANSPLANTATION; HUMAN; INCIDENCE; KAPLAN MEIER METHOD; LENGTH OF STAY; LOG RANK TEST; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; ORGAN DONOR; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; STATISTICAL SIGNIFICANCE; STROKE; STUDENT T TEST; SURVIVAL; UNITED STATES; UNIVARIATE ANALYSIS;

AGE FACTORS; AGED; AGED, 80 AND OVER; FEMALE; GRAFT REJECTION; HEART FAILURE; HEART TRANSPLANTATION; HUMANS; INCIDENCE; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); RETROSPECTIVE STUDIES; SURVIVAL RATE; TRANSPLANTATION; UNITED STATES;

EID: 84861905330     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2012.03.019     Document Type: Article

References (22)

1. Bach V, Tramaille S, Chavanon O, et al. Isolated coronary surgery in the octogenarian. Immediate results and analysis of long term survival rate and quality of life. Can J Cardiol 2008;24:718-5.
2. Krane M, Voss B, Hiebinger A, et al. Twenty years of cardiac surgery in patients aged 80 years and older: risks and benefits. Ann Thorac Surg 2011;91:506-13.
3. Thourani V, Ailawadi G, Szeto WY, et al. Outcomes of surgical aortic valve replacement in high-risk patients: a multiinstitutional study. Ann Thorac Surg 2011;91:49-55.
4. Kurlansky PA, Willams DB, Traad EA, Zucker M, Ebra G. Eighteen-year follow-up demonstrates prolonged survival and enhanced quality of life for octogenarians after coronary bypass grafting. J Thorac Cardiovasc Surg 2011;141:394-9.
5. Blanche C, Matloff JM, Denton TA, et al. Heart transplantation in patients 70 years of age and older: initial experience. Ann Thorac Surg 1996;62:1731-6. (Pubitemid 26421107)
6. Blanche C, Blanche DA, Kearney B, et al. Heart transplantation in patients seventy years of age and older: a comparative analysis of outcome. J Thorac Cardiovasc Surg 2001;121:532-41. (Pubitemid 32230222)
7. Morgan JA, John R, Mancini DM, Edwards NM. Should heart transplantation considered as a treatment option for patients aged 70 years of older? J Thorac Cardiovasc Surg 2004;127:1817-9. (Pubitemid 38725469)
8. Centers for Disease Control and Prevention. Life expectancy at birth, 65 and 75 years of age by race and sex, US 2010. www.cdc.gov/nchs/data/hus/hus10. pdf#022.
9. Holzhey DM, Shi W, Borger MA, et al. Minimally invasive versus sternotomy approach for mitral valve surgery in patients greater than 70 years old: a propensity matched comparison. Ann Thorac Surg 2011;91:401-5.
10. Nakamura K, Nakamura E, Niina K, Kojima K. Outcome after valve surgery in octogenarians and efficacy of early mobilization with early cardiac rehabilitation. Gen Thorac Cardiovasc Surg 2010;58:606-11.
11. Ascione R, Culliford L, Rogers CA, Wild J, Narajan P, Angelini CD. Mechanical heart valves in septuagenarians. J Card Surg 2008;23:8-16. (Pubitemid 351286927)
12. Rylski B, Suedkamp M, Beyersdorf F, et al. Outcome after surgery for acute aortic dissection type A in patients over 70 years: data analysis form the German Registry for Acute Aortic Dissection Type A (GERAADA). Eur J Cardiothorac Surg 2011;40:435-40.
13. Demers P, Moffatt S, Oyer PE, Hunt SA, Reitz BA, Robbins RC. Long term results of heart transplantation in patient older than 60 years. J Thorac Cardiovasc Surg 2003;126:224-31. (Pubitemid 36909961)
14. Baran DA, Galin ID, Courtney MC, et al. Cardiac transplantation in the older recipient: excellent long-term survival based on pretransplant screening. Transpl Proc 2003;35:2465-7.
15. Daneshwar DA, Czer LSC, Phan A, Trento A, Schwarz ER. Heart transplantation in the elderly: Why cardiac transplantation does not need to be limited to younger patients but can be safely performed in patients above 65 years of age. Ann Transpl 2010;15:110-9.
16. Weiss ES, Nwakanma LU, Patel ND, Yuh DD. Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: An analysis of the UNOS database. J Heart Lung Transplant 2008;27:184-91. (Pubitemid 351221048)
17. Fonarow G. How old is too old for heart transplantation? Curr Op Cardiol 2000;15:97-109.
18. Hakim FT, Gress RE. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens 2007;70:179-89. (Pubitemid 47106657)
19. Boldizsar F, Mikecz K, Glant TT. Immunosenecence and its potential modulation: lessons from mouse models. Expert Rev Clin Immunol 2010;6:353-7.
20. Trzonkowski P, Debska-Slizien A, Jankowska M, et al. Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells. Mech Ageing Dev 2010;131:96-104.
21. Slaughter MS, Rogers JG, Milano CA, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med 2009;361:2241-51.
22. Adamson RM, Stahovich M, Chillcott S, et al. Clinical strategies and outcomes in advanced heart failure patients older than 70 years of age receiving the Heart Mate II left ventricular assist device: a community hospital experience. J Am Coll Cardiol 0211;57:2487-95.