Heart transplantation in the elderly: Why cardiac transplantation does not need to be limited to younger patients but can be safely performed in patients above 65 years of age

Annals of Transplantation

Volumn 15, Issue 4, 2010, Pages 110-119

  Daneshvar, Daniel A ^a   Czer, Lawrence S C ^a   Phan, Anita ^a   Trento, Alfredo ^a   Schwarz, Ernst R ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Age; Elderly; Heart failure; Heart transplantation

Indexed keywords

CYCLOSPORIN; OKT 3;

AGE DISTRIBUTION; ARTICLE; ASSISTED CIRCULATION; BABY BOOMER; CARDIAC GRAFT REJECTION; GERIATRIC CARE; GERIATRIC PATIENT; GERIATRIC SURGERY; GRAFT RECIPIENT; HEART FAILURE; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIFE EXPECTANCY; NONHUMAN; PATIENT SAFETY; POSTOPERATIVE CARE; QUALITY OF LIFE; SURGICAL TECHNIQUE; SURVIVAL RATE; TREATMENT OUTCOME;

AGE FACTORS; AGED; HEART FAILURE; HEART TRANSPLANTATION; HUMANS; TREATMENT OUTCOME;

EID: 78651234585     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Redfield MM: Heart failure - an epidemic of uncertain proportions. N Engl J Med, 2002; 347: 1442-1444
2. Heart Disease and Stroke Statistics - 2009 Update, American Heart Association
3. Roger VL, Weston SA, Redfield MM et al: Trends in heart failure incidence and survival in a community- based population. JAMA 2004; 292: 344-350
4. McMurray JJ, Pfeffer MA: Heart failure. Lancet, 2005; 365: 1877-1889
5. Heart Disease and Stroke Statistics - 2009 Update, American Heart Association
6. th ed. New York, NY: McGraw Hill; 1998; 1287-1298
7. Heart Failure Society of America. HFSA 2006 comprehensive heart failure practice guideline. J Card Fail, 2006; 12: e1-e122
8. O'Connell JB, Bourge RC, Costanzo-Nordin MR et al: Cardiac transplantation: recipient selection, donor procurement, and medical follow-up. A statement for health professionals from the Committee on Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association. Circulation, 1992; 86: 1061-1079
9. Carrel A, Guthrie CC: The transplantation of veins and organs. American Medicine, 1905; 10: 1101-1102
10. Mann FC, Priestley JT, Markowitz J, Yater WM: Transplantation of the intact mammalian heart. Arch Surg, 1933; 26: 219-224
11. Hardy JD, Kurrus FD, Chavez CM et al: Heart transplantation in man. JAMA, 1964; 188: 1132-1140
12. Barnard CN: The operation. S Afr Med J, 1967; 30: 1271-1274
13. McGregor CGA: Evolution of heart transplantation. Cardiol Clin, 1990; 8: 3-10
14. Clark DA, Schroeder JS, Griepp RB et al: Cardiac transplantation in man: review of first three years' experience. Arn J Med, 1973; 54: 563-576
15. Schroeder JS, Rider AK, Stinson EB, Shumway NE: Cardiac transplantation: review of seven years' experience. Transplant Proc, 1976; 8: 5-8
16. McGregor CGA: Evolution of heart transplantation. Cardiol Clin, 1990; 8: 3-10
17. Solis E, Kaye MP: The Registry of the International Society for Heart Transplantation: third official report-June 1986. J Heart Transplant, 1986; 5: 2-5
18. 2006 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1996-2005. Available at: http://www.optn.org
19. Lower RR, Shumway NE: Studies on orthotopic homotransplantation of the canine heart Surg Forum, 1960; 11: 18-19
20. Sievers HH, Weyand M, Kraatz EG, Bernhard A: An alternative technique for orthotopic cardiac transplantation, with preservation of the normal anatomy of the right atrium. Thorac Cardiovasc Surg, 1991; 39: 70-72
21. Schnoor M, Schafer T, Luhmann D, Sievers HH: Bicaval versus standard technique in orthotopic heart transplantation: a systematic review and meta-analysis. J Thorac Cardiovasc Surg, 2007; 134: 1322-1331
22. Blanche C, Valenza M, Aleksic I et al: Technical considerations of a new technique for orthotopic heart transplantation. Total excision of recipient's atria with bicaval and pulmonary venous anastomoses. J Cardiovasc Surg, 1994; 35: 283-287
23. Hosenpud JD, Bennett LE, Keck BM et al: The Registry of the International Society for Heart and Lung Transplantation: seventeenth official report- 2000. J Heart Lung Transplant 2000;19: 909-931
24. Deng MC: Cardiac transplantation. Heart, 2002; 87: 177-84
25. Hoffman FM: Outcomes and complications after heart transplantation: a review. J Cardiovasc Nurs, 2005; 20 (Suppl.): S31-S42
26. Grady KL, Jalowiec A, White-Williams C: Improvement in quality of life in patients with heart failure who undergo transplantation. J Heart LungTransplant, 1996; 15: 749-57
27. United Network for Organ Sharing. 2000. Available at: http://www.unos.org/frame_default.asp
28. 2006 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1996-2005. Available at: http://www.optn.org/AR2006/waitlist_outcomes.htm
29. Hertz MI, Taylor DO, Trulock EP et al: The registry of the international society for heart and lung transplantation: nineteenth official report - 2002. J Heart Lung Transplant, 2002; 21: 950-70
30. Steinman TI, Becker BN, Frost AE et al: Clinical Practice Committee, American Society of Transplantation. Guidelines for the referral and management of patients eligible for solid organ transplantation. Transplantation, 2001; 71(9): 1189-204
31. Defraigne JO, Demoulin JC, Beaujean MA et al: Cardiac transplantation beyond 55 years of age. Transpl Int, 1990; 3: 59-61
32. Morgan JA, John R, Mancini DM, Edwards NM: Should heart transplantation be considered as a treatment option for patients aged 70 years and older? J Thorac Cardiovasc Surg, 2004; 127: 1817-1819
33. Forni A, Faggian G, Chiominto B et al: Heart transplantation in older candidates. Transplant Proc, 2007; 39: 1963-1966
34. Nagendran J, Wildhirt SM, Modry D et al: A comparative analysis of outcome after heart transplantation in patients aged 60 years and older: the University of Alberta experience. J Card Surg, 2004; 19: 559-62
35. The Organ Procurement and Transplantation Network. National data. Available at: http://www.optn.org/latestData/step2.asp
36. Blanche C, Kamlot A, Blanche DA et al: Heart transplantation with donors fifty years of age and older. J Thorac Cardiovasc Surg, 2002; 123: 810-815
37. Laks H, Marelli D, Fonarow GC et al: Use of two recipient lists for adults requiring heart transplantation. J Thorac Cardiovasc Surg, 2003; 125: 49-59
38. Chen JM, Russo MJ, Hammond KM et al: Alternate waiting list strategies for heart transplantation maximize donor organ utilization. Ann Thorac Surg, 2005; 80: 224-228
39. Lima B, Rajagopal K, Petersen RP et al: Marginal cardiac allografts do not have increased primary graft dysfunction in alternate list transplantation. Circulation, 2006; 114(Suppl.1): I27-132
40. Marelli D, Bresson J, Laks H et al: Hepatitis C-positive donors in heart transplantation. Am J Transplant, 2002; 2: 443-447
41. Marelli D, Laks H, Fazio D et al: The use of donor hearts with left ventricular hypertrophy. J Heart Lung Transplant, 2000; 19: 496-503
42. Taylor DO, Edwards LB, Boucek MM et al: Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult heart transplant report - 2005. J Heart Lung Transplant, 2005; 24: 945-955
43. Itescu S, Tung TC, Burke EM et al: An immunological algorithm to predict risk of high-grade rejection in cardiac transplant recipients. Lancet, 1998; 352: 263-270
44. Taylor DO, Edwards LB, Boucek MM et al: Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth official adult heart transplant report - 2007. J Heart Lung Transplant, 2007; 26: 769-781
45. Kapadia SR, Nissen SE, Ziada KM et al: Development of transplantation vasculopathy and progression of donor-transmitted atherosclerosis: comparison by serial intravascular ultrasound imaging. Circulation, 1998; 98 2672-2678
46. El Oakley RM, Yonan NA, Simpson BM, Deiraniya AK: Extended criteria for cardiac allograft donors: a consensus study. J Heart Lung Transplant, 1996; 15: 255-259
47. Conraads VM, Denollet J, Vorlat A et al: Screening for solid organ malignancies prior to heart ransplantation. Transplantation, 2001; 71: 1481-1483
48. U.S. Census Bureau, "International Data Base" (as of 18 June 2008); http://www.census.gov Review Paper Ann Transplant, 2010; 15(4): 110-119
49. Central Intelligence Agency. The World Factbook 2008
50. Fried LP: Epidemiology of aging. Epidemiol Rev, 2000; 22: 95-106
51. Lloyd-Jones DM, Larson MG, Leip EP et al: Framingham Heart Study. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation, 2002; 106: 3068-3072
52. Carrier M, Emery RW, Riley JE et al: Cardiac transplantation in patients over 50 years of age. J Am Coll Cardiol 1986; 8: 285-288
53. Organ Procurement and Transplantation Network. Organ by age. United Network for Organ Sharing, 2007. Available from: http://www.optn.org/latestData/rptData.asp
54. Taylor DO, Edwards LB, Boucek MM et al: The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult heart transplant report - 2004. J Heart Lung Transplant, 2004; 23: 796-803
55. Rickenbacher PR, Lewis NP, Valantine HA et al: Heart transplantation in patients over 54 years of age. Mortality, morbidity and quality of life. Eur Heart J, 1997; 18: 870-878
56. Billingham ME, Cary NR, Hammond ME et al: A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. J Heart Transplant, 1990; 9: 587-592
57. Tjang YS, van der Heijden GJ, Tenderich G et al: Impact of recipient's age on heart transplantation outcome. Ann Thorac Surg, 2008; 85: 2051-2055
58. Taylor DO, Edwards LB, Boucek MM et al: Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult heart transplantation report - 2006. J Heart Lung Transplant, 2006; 25: 869-879
59. The International Society for Heart & Lung Transplantation: ISHLT Transplant Quarterly Reports for Heart in North America, 2008. Available from: http://www.ishlt.org/registries
60. Blanche C, Matloff JM, Denton TA et al: Heart transplantation in patients 70 years of age and older: initial experience. Ann Thorac Surg, 1996; 62: 1731-1736
61. Blanche C, Blanche DA, Kearney B et al: Heart transplantation in patients seventy years of age and older: A comparative analysis of outcome. J Thorac Cardiovasc Surg, 2001; 121: 532-541
62. Weiss ES, Nwakanma LU, Patel ND, Yuh DD: Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database. J Heart Lung Transplant, 2008; 27: 184-191
63. Robbins RC: Ethical implications of heart transplantation in elderly patients. J Thorac Cardiovasc Surg, 2001; 121: 434-435
64. Cleland JG, Daubert JC, Erdmann E et al: Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Eng J Med, 2005; 352: 1539-1549
65. Bardy GH, Lee KL, Mark DB et al: Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Eng J Med, 2005; 352: 225-237
66. Rose EA, Gelijns AC, Moskowitz AJ et al: Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med, 2001; 345: 1435-1443
67. de Jonge N, Kirkels H, Lahpor JR et al: Exercise performance in patients with end-stage heart failure after implantation of a left ventricular assist device and after heart transplantation: an outlook for permanent assisting? J Am Coll Cardiol, 2001; 37: 1794-1799
68. Miller LW, Pagani FD, Russell SD et al: HeartMate II Clinical Investigators. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med, 2007; 357: 885-896
69. Fedak PW: Cardiac regeneration with embryonic stem cells: historic recapitulation of heart transplantation. Stem Cells Dev, 2008; 17(6): 1021-1022