Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 23, 2012, Pages 9089-9094

  Ritprajak, Patcharee ^a,b   Hayakawa, Morisada ^a   Sano, Yasuyo ^a   Otsu, Kinya ^c,d   Park, Jin Mo ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Allergic contact dermatitis; Contact hypersensitivity; Hapten

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 14;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL FUNCTION; CELL TYPE; CONTROLLED STUDY; DENDRITIC CELL; DISEASE EXACERBATION; ENZYME INHIBITION; EXPERIMENTAL MODEL; GENETIC TRANSCRIPTION; IMMUNOPATHOGENESIS; KERATINOCYTE; LYMPHOID TISSUE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SKIN ALLERGY; SKIN INFLAMMATION; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; DENDRITIC CELLS; DERMATITIS, ALLERGIC CONTACT; DINITROFLUOROBENZENE; DNA PRIMERS; DRUG DELIVERY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HAPTENS; IMMUNOBLOTTING; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 14; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

MUS;

EID: 84861892129     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1202984109     Document Type: Article

References (28)

1. Lee JC, et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746.
2. Han J, Lee JD, Bibbs L, Ulevitch RJ (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811. (Pubitemid 24266145)
3. Rouse J, et al. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78:1027-1037. (Pubitemid 24292330)
4. Freshney NW, et al. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78:1039-1049. (Pubitemid 24292331)
5. Cohen SB, et al. (2009) Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate- controlled study of patients with active rheumatoid arthritis. Arthritis Rheum 60:335-344.
6. Damjanov N, Kauffman RS, Spencer-Green GT (2009) Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum 60:1232-1241.
7. Genovese MC, et al. (2011) A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis. J Rheumatol 38:846-854.
8. Nestle FO, Di Meglio P, Qin JZ, Nickoloff BJ (2009) Skin immune sentinels in health and disease. Nat Rev Immunol 9:679-691.
9. Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958-969.
10. Borregaard N (2010) Neutrophils, from marrow to microbes. Immunity 33:657-670.
11. Kim C, et al. (2008) The kinase p38 α serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol 9:1019-1027.
12. + T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene. Eur J Immunol 25:3006-3010.
13. + T cells. J Exp Med 183:1001-1012.
14. +) T cell-mediated contact hypersensitivity. J Exp Med 189:779-786.
15. + T cells are the dominant effector cells in trinitrophenyl-specific contact hypersensitivity. J Invest Dermatol 115:260-266.
16. Gaestel M (2006) MAPKAP kinases - MKs - two's company, three's a crowd. Nat Rev Mol Cell Biol 7:120-130.
17. Martin SF, et al. (2008) Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity. J Exp Med 205:2151-2162.
18. (H)1 response to cutaneous sensitization. J Allergy Clin Immunol 123:875-882, e1.
19. Alferink J, et al. (2003) Compartmentalized production of CCL17 in vivo: Strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J Exp Med 197:585-599. (Pubitemid 36314654)
20. + T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol 181:8576-8584.
21. Semmling V, et al. (2010) Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11:313-320.
22. Stutte S, et al. (2010) Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells. Proc Natl Acad Sci USA 107:8736-8741.
23. Nishida K, et al. (2004) p38α mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol 24:10611-10620. (Pubitemid 39603120)
24. - dendritic cells in the spleen. J Exp Med 204:1653-1664.
25. Hennet T, Hagen FK, Tabak LA, Marth JD (1995) T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci USA 92:12070-12074.
26. Ritprajak P, Hashiguchi M, Azuma M (2008) Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells. Mol Ther 16:1323-1330. (Pubitemid 351866065)
27. + T cell responses. J Immunol 184:4918-4925.
28. Park JM, Ng VH, Maeda S, Rest RF, Karin M (2004) Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med 200:1647-1655. (Pubitemid 40094188)