Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells

Breast Cancer Research

Volumn 14, Issue 3, 2012, Pages

  Ren, Xiu Rong ^a   Wei, Junping ^a   Lei, Gangjun ^a   Wang, Jiangbo ^a   Lu, Jiuyi ^a   Xia, Wenle ^a   Spector, Neil ^a   Barak, Larry S ^a   Clay, Timothy M ^b   Osada, Takuya ^a   Hamilton, Erika ^a   Blackwell, Kimberly ^a   Hobeika, Amy C ^a   Morse, Michael A ^a   Lyerly, H Kim ^a   Chen, Wei ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRASTUZUMAB; ANTIBODY; CANCER VACCINE; ERBB2 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYCLONAL ACTIVATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL; UBIQUITINATION; VACCINATION; ANIMAL; BREAST TUMOR; C57BL MOUSE; CANCER TRANSPLANTATION; CELL MEMBRANE; CELL PROLIFERATION; CELL STRAIN HEK293; COATED VESICLE; ENDOCYTOSIS; FEMALE; IMMUNOLOGY; METABOLISM; NONOBESE DIABETIC MOUSE; PHOSPHORYLATION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTIBODIES; BREAST NEOPLASMS; CANCER VACCINES; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CLATHRIN-COATED VESICLES; ENDOCYTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; NEOPLASM TRANSPLANTATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; TRANSPLANTATION, HETEROLOGOUS; UBIQUITINATION; VACCINATION;

EID: 84861880890     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3204     Document Type: Article

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