Optical spectroscopic characteristics of lactate and mitochondrion as new biomarkers in cancer diagnosis: Understanding Warburg effect

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 8220, Issue , 2012, Pages

  Liu, C H ^a   Ni, X H ^a   Pu, Yang ^a   Yang, Y L ^a   Zhou, F ^a   Zuzolo, R ^a   Wang, W B ^a   Masilamani, V ^b   Rizwan, A ^c   Alfano, R R ^a  

^a CITY COLLEGE OF NEW YORK   (United States)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Breast tissues; Lactate and mitochondrion; Native fluorescence spectroscopy; Optical spectroscopy

Indexed keywords

BIOCHEMICAL COMPONENTS; BREAST CANCER; BREAST TISSUES; CANCER CELLS; CANCER DIAGNOSIS; FLUORESCENCE SPECTRA; HIGH RATE; MODEL COMPONENTS; MOLECULAR MARKER; NORMAL TISSUE; OPTICAL SPECTRA; OPTICAL SPECTROSCOPIC; OPTICAL SPECTROSCOPIC TECHNIQUES; OPTICAL SPECTROSCOPY; PATHOPHYSIOLOGICAL; STOKES SHIFT; WARBURG EFFECTS;

AMINO ACIDS; BIOPSY; CELLS; DISEASES; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; GLUCOSE; RAMAN SPECTROSCOPY;

TISSUE;

EID: 84861865465     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.909249     Document Type: Conference Paper

References (22)

1. M. Lopez-Lazaro. "The Warburg effect: Why and how do cancer cells activate glycolysis in the presence of oxygen?", Anti-Cancer Agents in Medicinal Chemistry, 8, pp.305-312 (2008).
2. O. Warburg, "On the origin of cancer cells", Science, 123, pp. 309-314 (1956).
3. O. Warburg, "On respiratory impairment in cancer cells", Science, 124, pp.269-270 (1956).
4. P. Shkarin, Q. He, "Lactate detection in human breast cancer on 2.1T MR system", Proc. Incl. Soc. Mag. Reson. Med., 9, 2327 (2001).
5. M.M. Brentani and M.A. Nagai, "Lactate dehydrogenase in breast carcinoma: correlation with estrogen and progesterone receptors", Cancer Detect Prev., 6, pp241-247 (1983).
6. L. DE Bari, G. Chieppa, E. Marra and S. Passarella, "L-lactate metabolism can occur in normal and cancer prostate cells via novel mitochondrial L-lactate dehydrogenase", International Journal of Oncology, 37, pp.1607-1620 (2010).
7. R. Bartrons, and J. Caro, "Hypoxia, glucose metabolism and the Warburg's effect", J Bioenerg Biomembr, 39, pp.223-229 (2007).
8. V. Gogvadze, S. Orrenius , and B. Zhivotovsky, "Mitochondria in cancer cells: what is so special about them?", Trends Cell Biol. 18, pp.165-173 (2008);
9. H.H. Kim, H. Joo, T. Kim, E. Kim,S-J Park, J. K. Park and H.J. Kim, "The mitochondrial Warburg effect: A cancer enigma", IBC Interdisciplinary Bio Central, 7, pp. 1-7 (2009).
10. S. Weinhouse, "The Warburg hypothesis fifty years later", Z. Krebsforsch Klin. Onkol. Cancer Res. Clin. Oncol. 87, pp.115-126 (1976);
11. S. Weinhouse S, "On respiratory impairment in cancer cells", Science, 124, pp. 267-269 (1956).
12. B. Chance and B. Hess?"Spectroscopic evidence of metabolic control", Science, 129, pp.700-708 (1959).
13. "New 'Achilles' heel' in breast cancer: tumor cell mitochondria" http://medicalxpress.com/news/2011-12-achilles-heel-breast- cancer-tumor.html
14. C. H. Liu, W. B. Wang, A. Alimova, V. Sriramoju, V. Kartazayev, and R. R. Alfano, "Monitoring changes of proteins and lipids in laser welded aorta tissue using biochemical component analyses", SPIE Proceeding, 7175, 717504 (2009).
15. E. Ackerstaff, B.R. Pflug, J. B. Nelson, Z.M. Bhujwalla, "Increased Lactate characterizes malignant transformation in Human prostate cancer cells", Proc. Intl. Soc. Mag. Reson. Med., 9, 2234 (2001).
16. R. Hussien and G. A. Brooks, "Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines", Physiol Genomics, Mar 16; 43(5), pp255-64 (2011 ).
17. Y. Shapovalov, D.Hoffman, D.Zuck, KL. De Mesy Bentley and RA. Eliseev, "Mitochondrial dysfunction in cancer cells duo to aberrant mitochondrial replication", J. Biol. Chem. 286 (25), pp.22331-22338 (2011).
18. R. R. Alfano and S. L. Shapiro. "Ultrafast phenomena in liquids and solids." Scientific American, 228, pp. 42-55 (1973).
19. R. R. Alfano and Yuanlong Yang, "Stokes shift emission spectroscopy of human tissue and key biomolecules" IEEE Journal of Selected Topics in Quantum Electronics, 9, No.2, pp. 148-153 (2003).
20. G.C. Prendergast, "Cancer: Why tumours eat tryptophan", Nature, 478, pp. 192-194 (2011).
21. R.A. Gatenby, and R. J. Gillies, "Why do cancers have high aerobic glycolysis? ", Nat Rev Cance,,r 4, pp. 891-899 (2004).
22. M.G. Vander Heiden, L.C. Cantley and C.B. Thompson, "Understanding the Warburg effect: the metabolic requirements of cell proliferation", Science, 324, pp.1029-1033 (2009).