Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in chuanxiong rhizoma in rat

Current Drug Metabolism

Volumn 13, Issue 5, 2012, Pages 524-534

  Yan, Ru ^a,b   Ko, Nga Ling ^a   Ma, Bin ^a   Tam, Yun Kau ^c   Lin, Ge ^a  

^a Prince of Wales Hospital   (Hong Kong)

^b University of Macau   (Macao)

^c Sinoveda Canada Inc   (Canada)

Author keywords

Chuanxiong Rhizoma; Metabolic conversion; Pharmacokinetics; Z butylidenephthalide

Indexed keywords

3 HYDROXY 3 BUTYLPHTHALIDE; BUTYLIDENEPHTHALIDE; DRUG METABOLITE; LIGUSTICUM CHUANXIONG EXTRACT; LIGUSTILIDE; PHTHALIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG EXPOSURE; DRUG ISOLATION; DRUG MEGADOSE; DRUG METABOLISM; DRUG STRUCTURE; IN VITRO STUDY; INTESTINE; LIGUSTICUM CHUANXIONG; LIVER METABOLISM; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84861862908     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/1389200211209050524     Document Type: Article

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