Apoptosis and inflammation: Role of adipokines in inflammatory bowel disease

Clinical and Translational Gastroenterology

Volumn 1, Issue , 2010, Pages

  Ponemone, Venkatesh ^a   Keshavarzian, Ali ^b   Brand, Marc I ^b   Saclarides, Theodore ^b   Abcarian, Herand ^a   Cabay, Robert J ^a   Fletcher, Emma ^c   Larsen, Bianca ^c   Durstine, Larry J ^c   Fantuzzi, Giamila ^a   Fayad, Raja ^a,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b RUSH UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; CD3 ANTIBODY; CHEMOKINE; CORTICOSTEROID; GROWTH FACTOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 6; LEPTIN; PROTEIN BCL 2; PROTEIN BCL XL; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ADIPOCYTE; ADIPOSE TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL INFILTRATION; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ACTIVITY; ENTERITIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; INFLAMMATION; INFLAMMATORY INFILTRATE; INTESTINE MUCOSA; LAMINA PROPRIA T LYMPHOCYTE; MALE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; ULCERATIVE COLITIS;

EID: 84861853313     PISSN: None     EISSN: 2155384X     Source Type: Journal    
DOI: 10.1038/ctg.2010.1     Document Type: Article

References (47)

1. Bu P, Keshavarzian A, Stone DD et al. Apoptosis: one of the mechanisms that maintains unresponsiveness of the intestinal mucosal immune system. J Immunol 2001; 166: 6399-6403. (Pubitemid 32440774)
2. Qiao L, Golling M, Autschbach F et al. T cell receptor repertoire and mitotic responses of lamina propria T lymphocytes in inflammatory bowel disease. Clin Exp Immunol 1994; 97: 303-308. (Pubitemid 24263075)
3. Autschbach F, Schurmann G, Qiao L et al. Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn's disease. Virchows Arch 1995; 426: 51-60.
4. Liu Z, Geboes K, Colpaert S et al. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J Immunol 2000; 164: 3608-3615. (Pubitemid 30169814)
5. Blain A, Cattan S, Beaugerie L et al. Crohn's disease clinical course and severity in obese patients. Clin Nutr 2002; 21: 51-57.
6. Sitaraman S, Liu X, Charrier L et al. Colonic leptin: source of a novel proinflammatory cytokine involved in IBD. Faseb J 2004; 18: 696-698.
7. Desreumaux P, Ernst O, Geboes K et al. Inflammatory alterations in mesenteric adipose tissue in Crohn's disease. Gastroenterology 1999; 117: 73-81. (Pubitemid 29297622)
8. Sheehan AL, Warren BF, Gear MW et al. Fat-wrapping in Crohn's disease: pathological basis and relevance to surgical practice. Br J Surg 1992; 79: 955-958.
9. Borley NR, Mortensen NJ, Jewell DP et al. The relationship between inflammatory and serosal connective tissue changes in ileal Crohn's disease: evidence for a possible causative link. J Pathol 2000; 190: 196-202. (Pubitemid 30082494)
10. Barbier M, Vidal H, Desreumaux P et al. Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases. Gastroenterol Clin Biol 2003; 27: 987-991. (Pubitemid 37516823)
11. Yamamoto K, Kiyohara T, Murayama Y et al. Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. Gut 2005; 54: 789-796. (Pubitemid 40732095)
12. Lord GM, Matarese G, Howard JK et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897-901. (Pubitemid 28410912)
13. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005; 115: 911-919; quiz 920.
14. Fayad R, Pini M, Sennello JA et al. Adiponectin deficiency protects mice from chemically induced colonic inflammation. Gastroenterology 2007; 132: 601-614. (Pubitemid 46274660)
15. Ehling A, Schaffler A, Herfarth H et al. The potential of adiponectin in driving arthritis. J Immunol 2006; 176: 4468-4478. (Pubitemid 44264427)
16. Ogunwobi OO, Beales IL. Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regul Pept 2006; 134: 105-113.
17. Lovato P, Brender C, Agnholt J et al. Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J Biol Chem 2003; 278: 16777-16781. (Pubitemid 36799545)
18. Liao W, Yu C, Wen J et al. Adiponectin Induces Interleukin-6 Production and Activates STAT3 in Adult Mouse Cardiac Fibroblasts. Biol Cell 2008; 101: 263-272.
19. Akira S. IL-6-regulated transcription factors. Int J Biochem Cell Biol 1997; 29: 1401-1418. (Pubitemid 28153490)
20. Miyazaki T, Bub JD, Uzuki M et al. Adiponectin activates c-Jun NH(2)-terminal kinase and inhibits signal transducer and activator of transcription 3. Biochem Biophys Res Commun 2005; 333: 79-87. (Pubitemid 40813449)
21. Riley JK, Takeda K, Akira S et al. Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. J Biol Chem 1999; 274: 16513-16521.
22. Atreya R, Mudter J, Finotto S et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 2000; 6: 583-588. (Pubitemid 30305911)
23. Catlett-Falcone R, Landowski TH, Oshiro MM et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999; 10: 105-115. (Pubitemid 29077388)
24. Fayad R, Brand MI, Stone D et al. Apoptosis resistance in ulcerative colitis: high expression of decoy receptors by lamina propria T cells. Eur J Immunol 2006; 36: 2215-2222. (Pubitemid 44251766)
25. Haugen F, Drevon CA. Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Endocrinology 2007; 148: 5478-5486. (Pubitemid 350012628)
26. Neumeier M, Weigert J, Schaffler A et al. Different effects of adiponectin isoforms in human monocytic cells. J Leukoc Biol 2006; 79: 803-808. (Pubitemid 44835612)
27. Schaffler A, Furst A, Buchler C et al. Secretion of RANTES (CCL5) and interleukin-10 from mesenteric adipose tissue and from creeping fat in Crohn's disease: regulation by steroid treatment. J Gastroenterol Hepatol 2006; 21: 1412-1418. (Pubitemid 44154709)
28. Hue S, Ahern P, Buonocore S et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med 2006; 203: 2473-2483. (Pubitemid 44664617)
29. Saad MF, Damani S, Gingerich RL et al. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 1997; 82: 579-584. (Pubitemid 27068633)
30. Rovin BH, Song H. Chemokine induction by the adipocyte-derived cytokine adiponectin. Clin Immunol 2006; 120: 99-105. (Pubitemid 43903386)
31. Hemmrich K, Thomas GP, Abberton KM et al. Monocyte chemoattractant protein-1 and nitric oxide promote adipogenesis in a model that mimics obesity. Obesity (Silver Spring) 2007; 15: 2951-2957. (Pubitemid 351256656)
32. Sobhani I, Buyse M, Goiot H et al. Vagal stimulation rapidly increases leptin secretion in human stomach. Gastroenterology 2002; 122: 259-263. (Pubitemid 34116978)
33. Doering J, Begue B, Lentze MJ et al. Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease. Gut 2004; 53: 1632-1638. (Pubitemid 39434107)
34. Itoh J, de La Motte C, Strong SA et al. Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease. Gut 2001; 49: 35-41. (Pubitemid 32601877)
35. Fujita Y, Murakami M, Ogawa Y et al. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol 2002; 128: 21-26. (Pubitemid 34451175)
36. Brakenhielm E, Veitonmaki N, Cao R et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA 2004; 101: 2476-2481. (Pubitemid 38269336)
37. Rakatzi I, Mueller H, Ritzeler O et al. Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1. Diabetologia 2004; 47: 249-258. (Pubitemid 38315361)
38. Lu Y, Fukuyama S, Yoshida R et al. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. J Biol Chem 2006; 281: 36683-36690. (Pubitemid 46042135)
39. Coll ML, Rosen K, Ladeda V et al. Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells. Oncogene 2002; 21: 2908-2913. (Pubitemid 34499390)
40. Lappas M, Permezel M, Rice GE. Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase 1/2. Endocrinology 2005; 146: 3334-3342. (Pubitemid 41058105)
41. Alberti L, Gilardini L, Girola A et al. Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients. Diabetes Obes Metab 2007; 9: 344-349. (Pubitemid 46502053)
42. Shirogane T, Fukada T, Muller JM et al. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 1999; 11: 709-719. (Pubitemid 30030710)
43. Ina K, Itoh J, Fukushima K et al. Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol 1999; 163: 1081-1090. (Pubitemid 29328123)
44. Croker BA, Krebs DL, Zhang JG et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 2003; 4: 540-545. (Pubitemid 36701336)
45. Pajvani UB, Hawkins M, Combs TP et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004; 279: 12152-12162. (Pubitemid 38445780)
46. Tomizawa A, Hattori Y, Kasai K et al. Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells: globular adiponectin vs. high molecular weight adiponectin. Diab Vasc Dis Res 2008; 5: 123-127. (Pubitemid 351839284)
47. Hattori Y, Hattori S, Kasai K. Globular adiponectin activates nuclear factor-kappaB in vascular endothelial cells, which in turn induces expression of proinflammatory and adhesion molecule genes. Diabetes Care 2006; 29: 139-141. (Pubitemid 44033447)