Excess electron interactions with solvated DNA nucleotides: Strand breaks possible at room temperature

Journal of the American Chemical Society

Volumn 134, Issue 22, 2012, Pages 9122-9125

  Smyth, Maeve ^a   Kohanoff, Jorge ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MATTER; BOND CLEAVAGES; DNA FRAGMENT; DNA NUCLEOTIDES; EXCESS ELECTRONS; FIRST-PRINCIPLES STUDY; LOW ENERGIES; LOW ENERGY ELECTRONS; NUCLEOBASES; PHOSPHODIESTERS; ROOM TEMPERATURE; STRAND BREAKS; THERMAL FLUCTUATIONS;

IONIZING RADIATION; NUCLEOTIDES;

DNA;

DNA; DNA FRAGMENT; ESTER DERIVATIVE; GUANOSINE PHOSPHATE; NUCLEIC ACID BASE; NUCLEOTIDE DERIVATIVE; PHOSPHORUS DERIVATIVE;

ARTICLE; BINDING AFFINITY; CHEMICAL BOND; DNA CLEAVAGE; DNA STRAND; DNA STRAND BREAKAGE; ELECTRON; ENERGY; IONIZING RADIATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; ROOM TEMPERATURE; SOLVATION;

DNA; ELECTRONS; NUCLEOTIDES; SOLUBILITY; TEMPERATURE;

EID: 84861849914     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja303776r     Document Type: Article

References (31)

1. Baccarelli, I.; Gianturco, F. A.; Scifoni, E.; Solovyov, A. V.; Surdutovich, E. Eur. Phys. J. D 2010, 60, 1
2. Baccarelli, I.; Bald, I.; Gianturco, F. A.; Illenberger, E.; Kopyra, J. Phys. Rep. 2011, 508, 1
3. Boudaiffa, B.; Cloutier, P.; Hunting, D.; Huels, M. A.; Sanche, L. Science 2000, 287, 1658
4. Pan, X.; Cloutier, P.; Hunting, D.; Sanche, L. Phys. Rev. Lett. 2003, 90 208102
5. Winstead, C.; McKoy, V. J. Chem. Phys. 2006, 125 244302
6. Lyngdoh, R.; Schaeffer, H. Acc. Chem. Res. 2009, 42, 563
7. Siefermann, K. R.; Liu, Y.; Lugovoy, E.; Link, O.; Faubel, M.; Buck, U.; Winter, B.; Abel, B. Nat. Chem. 2010, 2, 274
8. Wang, C.-R.; Luo, T.; Lu, Q.-B. Phys. Chem. Chem. Phys. 2008, 10, 4463
9. Wang, C.-R.; Nguyen, J.; Lu, Q.-B. J. Am. Chem. Soc. 2009, 131, 11320
10. Li, X.; Sevilla, M.; Sanche, L. J. Am. Chem. Soc. 2003, 125, 13668
11. Berdys, J.; Anusiewicz, I.; Skurski, P.; Simons, J. J. Am. Chem. Soc. 2004, 126, 6441
12. Gu, J.; Xie, Y.; Schaeffer, H. ChemPhysChem. 2006, 7, 1885
13. Gu, J.; Wang, J.; Leszczynski, J. J. Am. Chem. Soc. 2006, 128, 9322
14. Kumar, A.; Sevilla, M. J. Phys. Chem. B 2007, 111, 5464
15. Li, Z.; Xheng, Y.; Cloutier, P.; Sanche, L.; Wagner, J. R. J. Am. Chem. Soc. 2008, 130, 5612
16. Gu, J.; Xie, Y.; Schaeffer, H. Nucleic Acids Res. 2007, 35, 5165
17. Gu, J.; Wang, J.; Leszczynski, J. Nucleic Acids Res. 2010, 38, 5280
18. Gu, J.; Wang, J.; Leszczynski, J. J. Phys. Chem. B 2011, 115, 14831
19. Simons, J. Acc. Chem. Res. 2006, 39, 772
20. Schyman, P.; Laaksonen, A. J. Am. Chem. Soc. 2008, 130, 12254
21. Gu, J.; Wang, J.; Leszczynski, J. ChemPhysChem 2010, 11, 175
22. Schyman, P.; Laaksonen, A.; Hogosson, H. Chem. Phys. Lett. 2008, 462, 289
23. Smyth, M.; Kohanoff, J. Phys. Rev. Lett. 2011, 106 238108
24. Youngs, T. G. A. J. Comput. Chem. 2009, 31, 639
25. Smith, W.; Yong, C. W.; Rodger, P. M. Mol. Simul. 2002, 28, 385
26. VandeVondele, J.; Krack, M.; Mohamed, F.; Parrinello, M.; Chassaing, T.; Hutter, J. Comput. Phys. Commun. 2005, 167, 103
27. Martyna, G. J.; Tuckerman, M. E. J. Chem. Phys. 1999, 110, 2810
28. Goedecker, S.; Teter, M.; Hutter, J. Phys. Rev. B 1996, 54, 1703
29. Perdew, J. P.; Burke, K.; Ernzerhof, M. Phys. Rev. Lett. 1996, 77, 3865
30. Sprik, M.; Cicotti, G. J. Chem. Phys. 1998, 109, 7737
31. Swarts, S. G.; Gilbert, D. C.; Sharma, K. K.; Razskazovskiy, Y.; Purkayastha, S.; Naumentko, K. A.; Bernhard, W. A. Radiat. Res. 2007, 168, 367