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Volumn 110, Issue 3, 2009, Pages 516-528

Desflurane-induced postconditioning is mediated by β-adrenergic signaling: Role of β1-and β2-adrenergic receptors, protein kinase A, and calcium/Calmodulin-dependent protein kinase II

Author keywords

[No Author keywords available]

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; DESFLURANE; ESMOLOL; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PENTOBARBITAL; PHOSPHOLAMBAN; PROTEIN KINASE B; TRIPHENYLTETRAZOLIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; DRUG DERIVATIVE; ISOFLURANE;

EID: 62349120462     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318197ff62     Document Type: Article
Times cited : (41)

References (50)
  • 1
    • 34548746306 scopus 로고    scopus 로고
    • Myocardial reperfusion injury
    • Yellon DM, Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med 2007; 357:1121-35
    • (2007) N Engl J Med , vol.357 , pp. 1121-1135
    • Yellon, D.M.1    Hausenloy, D.J.2
  • 2
    • 0031744198 scopus 로고    scopus 로고
    • Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo
    • Preckel B, Schlack W, Comfere T, Obal D, Barthel H, Thamer V: Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo. Br J Anaesth 1998; 81:905-12
    • (1998) Br J Anaesth , vol.81 , pp. 905-912
    • Preckel, B.1    Schlack, W.2    Comfere, T.3    Obal, D.4    Barthel, H.5    Thamer, V.6
  • 3
    • 0031743449 scopus 로고    scopus 로고
    • Effects of halothane, enflurane, isoflurane, sevoflurane and desflurane on myocardial reperfusion injury in the isolated rat heart
    • Schlack W, Preckel B, Stunneck D, Thamer V: Effects of halothane, enflurane, isoflurane, sevoflurane and desflurane on myocardial reperfusion injury in the isolated rat heart. Br J Anaesth 1998; 81:913-9
    • (1998) Br J Anaesth , vol.81 , pp. 913-919
    • Schlack, W.1    Preckel, B.2    Stunneck, D.3    Thamer, V.4
  • 5
    • 34547588184 scopus 로고    scopus 로고
    • Brodkin iG, Liu H: Anesthetic preconditioning combined with postconditioning offers no additional benefit over preconditioning or postconditioning alone
    • Deyhimy Di, Fleming NW, Brodkin iG, Liu H: Anesthetic preconditioning combined with postconditioning offers no additional benefit over preconditioning or postconditioning alone. Anesth Analg 2007; 105:316-24
    • (2007) Anesth Analg , vol.105 , pp. 316-324
    • Di, D.1    Fleming, N.W.2
  • 6
    • 33748133067 scopus 로고    scopus 로고
    • Lange M, Smul TM, Blomeyer CA, Redel A, Klotz KN, Roewer N, Kehl F: Role of the adrenergic pathway in anesthetic and ischemic preconditioning against myocardial infarction in the rabbit heart in vivo.ANESTHEsioLOGY 2006;105:503-10
    • Lange M, Smul TM, Blomeyer CA, Redel A, Klotz KN, Roewer N, Kehl F: Role of the adrenergic pathway in anesthetic and ischemic preconditioning against myocardial infarction in the rabbit heart in vivo.ANESTHEsioLOGY 2006;105:503-10
  • 7
    • 0000582530 scopus 로고    scopus 로고
    • Revised Guide for the Care and Use of Laboratory Animals available. American Physiological Society
    • Bayne K: Revised Guide for the Care and Use of Laboratory Animals available. American Physiological Society. Physiologist 1996; 39:199, 208-11
    • (1996) Physiologist , vol.39 , Issue.199 , pp. 208-211
    • Bayne, K.1
  • 8
    • 0025352812 scopus 로고
    • An evaluation of three intravenous anesthetic regimens in New Zealand rabbits
    • Borkowski GL, Danneman PJ, Russell GB, Lang CM: An evaluation of three intravenous anesthetic regimens in New Zealand rabbits. Lab Anim Sci 1990; 40:270-6
    • (1990) Lab Anim Sci , vol.40 , pp. 270-276
    • Borkowski, G.L.1    Danneman, P.J.2    Russell, G.B.3    Lang, C.M.4
  • 10
    • 0014991754 scopus 로고
    • Regional differentiation of sympathetic activity during hypothalamic heating and cooling in anesthetized rabbits
    • iriki M, Riedel W, Simon E: Regional differentiation of sympathetic activity during hypothalamic heating and cooling in anesthetized rabbits. Pflugers Arch 1971; 328:320-31
    • (1971) Pflugers Arch , vol.328 , pp. 320-331
    • iriki, M.1    Riedel, W.2    Simon, E.3
  • 13
    • 85175936353 scopus 로고    scopus 로고
    • Thandroyen FT, Muntz KH, Buja LM, Willerson JT: Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion Circulation 1990; 82:ii30-7
    • Thandroyen FT, Muntz KH, Buja LM, Willerson JT: Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion Circulation 1990; 82:ii30-7
  • 14
    • 67649843760 scopus 로고    scopus 로고
    • Prabu SK, Anandatheerthavarada HK, Raza H, Srinivasan S, Spear JF, Avadhani NG: Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury
    • Prabu SK, Anandatheerthavarada HK, Raza H, Srinivasan S, Spear JF, Avadhani NG: Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury.
  • 15
    • 33644867986 scopus 로고    scopus 로고
    • J Biol Chem 2006; 281:2061-70
    • (2006) J Biol Chem , vol.281 , pp. 2061-2070
  • 17
    • 0035852780 scopus 로고    scopus 로고
    • Galcera-Tomas J, Castillo-Soria FJ, Villegas-Garcia MM, Florenciano-Sanchez R, Sanchez-Villanueva JG, de La Rosa JA, Martinez-Caballero A, Valenti-Aldeguer JA, Jara-Perez P, Parraga-Ramirez M, Lopez-Martinez i, inigo-Garcia L, Pico-Aracil F: Effects of early use of atenolol or captopril on infarct size and ventricular A double-blind comparison in patients with anterior acute myocardial infarction. Circulation 2001; 103:813-9
    • Galcera-Tomas J, Castillo-Soria FJ, Villegas-Garcia MM, Florenciano-Sanchez R, Sanchez-Villanueva JG, de La Rosa JA, Martinez-Caballero A, Valenti-Aldeguer JA, Jara-Perez P, Parraga-Ramirez M, Lopez-Martinez i, inigo-Garcia L, Pico-Aracil F: Effects of early use of atenolol or captopril on infarct size and ventricular volume: A double-blind comparison in patients with anterior acute myocardial infarction. Circulation 2001; 103:813-9
  • 18
    • 0031854958 scopus 로고    scopus 로고
    • Ruffolo RRJr, Ma XL: Comparison of metoprolol and carvedilol pharmacology and cardiopro-tection in rabbit ischemia and reperfusion model
    • FeuersteinG, Liu GL, Yue TL, ChengHY, Hieble JP, ArchJR, Ruffolo RRJr, Ma XL: Comparison of metoprolol and carvedilol pharmacology and cardiopro-tection in rabbit ischemia and reperfusion model. Eur J Pharmacol 1998; 351: 341-50
    • (1998) Eur J Pharmacol , vol.351 , pp. 341-350
    • Feuerstein, G.1    Liu, G.L.2    Yue, T.L.3    Cheng, H.Y.4    Hieble, J.P.5    Arch, J.R.6
  • 20
    • 0027178608 scopus 로고
    • Sympathetic hyperactivity during desflurane anesthesia in healthy volunteers: A comparison with isoflurane
    • Ebert TJ, Muzi M: Sympathetic hyperactivity during desflurane anesthesia in healthy volunteers: A comparison with isoflurane. Anesthesiology 1993; 79: 444-53
    • (1993) Anesthesiology , vol.79 , pp. 444-453
    • Ebert, T.J.1    Muzi, M.2
  • 21
    • 33750543369 scopus 로고    scopus 로고
    • Influence of beta-adrenoceptor blockade on the myocardial accumulation of fatty acid tracer and its intracellular metabolism in the heart after ischemia-reperfusion injury
    • igarashi N, Nozawa T, Fujii N, Suzuki T, Matsuki A, Nakadate T, igawa A, Inoue H: Influence of beta-adrenoceptor blockade on the myocardial accumulation of fatty acid tracer and its intracellular metabolism in the heart after ischemia-reperfusion injury. Circ J 2006; 70:1509-14
    • (2006) Circ J , vol.70 , pp. 1509-1514
    • igarashi, N.1    Nozawa, T.2    Fujii, N.3    Suzuki, T.4    Matsuki, A.5    Nakadate, T.6    igawa, A.7    Inoue, H.8
  • 22
    • 0025109130 scopus 로고
    • Possible involvement of membrane-stabilizing action in beneficial effect of beta adrenocep-tor blocking agents on hypoxic and posthypoxic myocardium
    • Takeo S, Yamada H, Tanonaka K, Hayashi M, Sunagawa N: Possible involvement of membrane-stabilizing action in beneficial effect of beta adrenocep-tor blocking agents on hypoxic and posthypoxic myocardium. J Pharmacol Exp Ther 1990; 254:847-56
    • (1990) J Pharmacol Exp Ther , vol.254 , pp. 847-856
    • Takeo, S.1    Yamada, H.2    Tanonaka, K.3    Hayashi, M.4    Sunagawa, N.5
  • 23
    • 0023552693 scopus 로고
    • Propranolol inhibition of the neutral phospholipases A of rat heart mitochondria, sarcoplasmic reticulum and cytosol
    • Trotz M, Jellison EJ, Hostetler KY: Propranolol inhibition of the neutral phospholipases A of rat heart mitochondria, sarcoplasmic reticulum and cytosol. Biochem Pharmacol 1987; 36:4251-6
    • (1987) Biochem Pharmacol , vol.36 , pp. 4251-4256
    • Trotz, M.1    Jellison, E.J.2    Hostetler, K.Y.3
  • 24
    • 3042659100 scopus 로고    scopus 로고
    • Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications
    • Xiao RP, Zhu W, Zheng M, Chakir K, Bond R, Lakatta EG, Cheng H: Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications. Trends Pharmacol Sci 2004; 25:358-65
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 358-365
    • Xiao, R.P.1    Zhu, W.2    Zheng, M.3    Chakir, K.4    Bond, R.5    Lakatta, E.G.6    Cheng, H.7
  • 25
    • 0035951823 scopus 로고    scopus 로고
    • Bernardi P: Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart
    • Di Lisa F, Menabo R, Canton M, Barile M, Bernardi P: opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart. J Biol Chem 2001; 276:2571-5
    • (2001) J Biol Chem , vol.276 , pp. 2571-2575
    • Di Lisa, F.1    Menabo, R.2    Canton, M.3    Barile, M.4
  • 26
    • 0028968606 scopus 로고
    • Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion
    • Griffiths EJ, Halestrap AP: Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J 1995; 307(pt 1):93-8
    • (1995) Biochem J , vol.307 , Issue.PART 1 , pp. 93-98
    • Griffiths, E.J.1    Halestrap, A.P.2
  • 27
    • 33645994183 scopus 로고    scopus 로고
    • Calcium, mitochondria and reperfusion injury: A pore way to die
    • Halestrap AP: Calcium, mitochondria and reperfusion injury: A pore way to die. Biochem Soc Trans 2006; 34:232-7
    • (2006) Biochem Soc Trans , vol.34 , pp. 232-237
    • Halestrap, A.P.1
  • 28
    • 11444267248 scopus 로고    scopus 로고
    • Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: Evidence for anesthetic-induced postconditioning in rabbits
    • Chiari PC, Bienengraeber MW, Pagel PS, Krolikowski JG, Kersten JR, Warltier DC: Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: Evidence for anesthetic-induced postconditioning in rabbits. Anesthesiology 2005; 102:102-9
    • (2005) Anesthesiology , vol.102 , pp. 102-109
    • Chiari, P.C.1    Bienengraeber, M.W.2    Pagel, P.S.3    Krolikowski, J.G.4    Kersten, J.R.5    Warltier, D.C.6
  • 29
    • 28344451998 scopus 로고    scopus 로고
    • Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: The role of mitochondrial KATP channels
    • Krolikowski JG, Bienengraeber M, Weihrauch D, Warltier DC, Kersten JR, Pagel PS: Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: The role of mitochondrial KATP channels. Anesth Analg 2005; 101:1590-6
    • (2005) Anesth Analg , vol.101 , pp. 1590-1596
    • Krolikowski, J.G.1    Bienengraeber, M.2    Weihrauch, D.3    Warltier, D.C.4    Kersten, J.R.5    Pagel, P.S.6
  • 31
    • 15744392510 scopus 로고    scopus 로고
    • Makaula S, Lochner A, Genade S, Sack MN, Awan MM, Opie LH: H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recoveryand reduces infarctsize. JCardiovasc Pharmacol2005; 45:341-7
    • Makaula S, Lochner A, Genade S, Sack MN, Awan MM, Opie LH: H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recoveryand reduces infarctsize. JCardiovasc Pharmacol2005; 45:341-7
  • 32
    • 3042813423 scopus 로고    scopus 로고
    • Sanada S, Asanuma H, Tsukamoto o, Minamino T, Node K, Takashima S, Fukushima T, Ogai A, Shinozaki Y, Fujita M, Hirata A, Okuda H, Shimokawa H, Tomoike H, Hori M, Kitakaze M: Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C. Circulation 2004; 110:51-7
    • Sanada S, Asanuma H, Tsukamoto o, Minamino T, Node K, Takashima S, Fukushima T, Ogai A, Shinozaki Y, Fujita M, Hirata A, Okuda H, Shimokawa H, Tomoike H, Hori M, Kitakaze M: Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C. Circulation 2004; 110:51-7
  • 33
    • 38549115033 scopus 로고    scopus 로고
    • Activation of mitochondrial large-conductance calcium-activated K+ channels via protein kinase A mediates desflurane-induced preconditioning
    • Redel A, Lange M, Jazbutyte V, Lotz C, Smul TM, Roewer N, Kehl F: Activation of mitochondrial large-conductance calcium-activated K+ channels via protein kinase A mediates desflurane-induced preconditioning. Anesth Analg 2008; 106:384-91
    • (2008) Anesth Analg , vol.106 , pp. 384-391
    • Redel, A.1    Lange, M.2    Jazbutyte, V.3    Lotz, C.4    Smul, T.M.5    Roewer, N.6    Kehl, F.7
  • 35
    • 6344258936 scopus 로고    scopus 로고
    • Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodu-lin kinase signaling pathway
    • Wang W, Zhu W, Wang S, Yang D, Crow MT, Xiao RP, Cheng H: Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodu-lin kinase signaling pathway. Circ Res 2004; 95:798-806
    • (2004) Circ Res , vol.95 , pp. 798-806
    • Wang, W.1    Zhu, W.2    Wang, S.3    Yang, D.4    Crow, M.T.5    Xiao, R.P.6    Cheng, H.7
  • 37
    • 0033515617 scopus 로고    scopus 로고
    • Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium
    • Hoch B, Meyer R, Hetzer R, Krause EG, Karczewski P: Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ Res 1999; 84:713-21
    • (1999) Circ Res , vol.84 , pp. 713-721
    • Hoch, B.1    Meyer, R.2    Hetzer, R.3    Krause, E.G.4    Karczewski, P.5
  • 38
    • 33846888073 scopus 로고    scopus 로고
    • Ca2+/calmodulin-depen-dent protein kinase: A key component in the contractile recovery from acidosis
    • Mattiazzi A, Vittone L, Mundina-Weilenmann C: Ca2+/calmodulin-depen-dent protein kinase: A key component in the contractile recovery from acidosis. Cardiovasc Res 2007; 73:648-56
    • (2007) Cardiovasc Res , vol.73 , pp. 648-656
    • Mattiazzi, A.1    Vittone, L.2    Mundina-Weilenmann, C.3
  • 40
    • 14244258686 scopus 로고    scopus 로고
    • Signal transduction mechanisms involved in cardiac preconditioning: Role of Ras-GT-Pase, Ca2 +/calmodulin-dependent protein kinase II and epidermal growth factor receptor
    • Benter IF, Juggi JS, Khan I, Yousif MH, Canatan H, Akhtar S: Signal transduction mechanisms involved in cardiac preconditioning: role of Ras-GT-Pase, Ca2 +/calmodulin-dependent protein kinase II and epidermal growth factor receptor. Mol Cell Biochem 2005; 268:175-83
    • (2005) Mol Cell Biochem , vol.268 , pp. 175-183
    • Benter, I.F.1    Juggi, J.S.2    Khan, I.3    Yousif, M.H.4    Canatan, H.5    Akhtar, S.6
  • 41
    • 48949119084 scopus 로고    scopus 로고
    • Differential role of calcium/calmodulin-dependent protein kinase II in desflurane-induced preconditioning and cardioprotection by metoprolol: Met-oprolol blocks desflurane-induced preconditioning
    • Lange M, Smul TM, Redel A, Lotz C, Jazbutyte V, Schnupp V, Roewer N, Kehl F: Differential role of calcium/calmodulin-dependent protein kinase II in desflurane-induced preconditioning and cardioprotection by metoprolol: Met-oprolol blocks desflurane-induced preconditioning. Anesthesiology 2008; 109: 72-80
    • (2008) Anesthesiology , vol.109 , pp. 72-80
    • Lange, M.1    Smul, T.M.2    Redel, A.3    Lotz, C.4    Jazbutyte, V.5    Schnupp, V.6    Roewer, N.7    Kehl, F.8
  • 42
    • 33846858884 scopus 로고    scopus 로고
    • Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart
    • Maier LS, Bers DM: Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res 2007; 73:631-40
    • (2007) Cardiovasc Res , vol.73 , pp. 631-640
    • Maier, L.S.1    Bers, D.M.2
  • 43
    • 37349117286 scopus 로고    scopus 로고
    • Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels
    • An J, Bosnjak ZJ, Jiang MT: Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels. Anesth Analg 2007; 105:1207-13
    • (2007) Anesth Analg , vol.105 , pp. 1207-1213
    • An, J.1    Bosnjak, Z.J.2    Jiang, M.T.3
  • 44
    • 25444476096 scopus 로고    scopus 로고
    • The negative inotropic effect of esmolol on isolated cardiac muscle
    • Arlock P, Wohlfart B, Sjoberg T, Steen S: The negative inotropic effect of esmolol on isolated cardiac muscle. Scand Cardiovasc J 2005; 39:250-4
    • (2005) Scand Cardiovasc J , vol.39 , pp. 250-254
    • Arlock, P.1    Wohlfart, B.2    Sjoberg, T.3    Steen, S.4
  • 45
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P: Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351:95-105
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 46
    • 0025248571 scopus 로고
    • Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquino- linesulfonamide (H-89), of PC12D pheochromocytoma cells
    • Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, Hidaka H: Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquino- linesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 1990; 265:5267-72
    • (1990) J Biol Chem , vol.265 , pp. 5267-5272
    • Chijiwa, T.1    Mishima, A.2    Hagiwara, M.3    Sano, M.4    Hayashi, K.5    Inoue, T.6    Naito, K.7    Toshioka, T.8    Hidaka, H.9
  • 47
    • 30544433778 scopus 로고    scopus 로고
    • The protein kinase A inhibitor, H-89, directly inhibits KATP and Kir channels in rabbit coronary arterial smooth muscle cells
    • Sun PW, Kyoung SY, Kim N, Boum YJ, Joo H, Warda M, Ko JH, Earm YE, Han J: The protein kinase A inhibitor, H-89, directly inhibits KATP and Kir channels in rabbit coronary arterial smooth muscle cells. Biochem Biophys Res Commun 2006; 340:1104-10
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 1104-1110
    • Sun, P.W.1    Kyoung, S.Y.2    Kim, N.3    Boum, Y.J.4    Joo, H.5    Warda, M.6    Ko, J.H.7    Earm, Y.E.8    Han, J.9
  • 48
    • 0036035333 scopus 로고    scopus 로고
    • Dynamics of Ca(2+)/calmodulin-dependent protein kinase II following acute myocardial ischemia-translocation and autophosphorylation
    • Uemura A, Naito Y, Matsubara T: Dynamics of Ca(2+)/calmodulin-dependent protein kinase II following acute myocardial ischemia-translocation and autophosphorylation. Biochem Biophys Res Commun 2002; 297: 997-1002
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 997-1002
    • Uemura, A.1    Naito, Y.2    Matsubara, T.3
  • 49
    • 0026345859 scopus 로고
    • The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells
    • Sumi M, Kiuchi K, Ishikawa T, Ishii A, Hagiwara M, Nagatsu T, Hidaka H: The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun 1991; 181:968-75
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 968-975
    • Sumi, M.1    Kiuchi, K.2    Ishikawa, T.3    Ishii, A.4    Hagiwara, M.5    Nagatsu, T.6    Hidaka, H.7
  • 50
    • 0032239112 scopus 로고    scopus 로고
    • KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart
    • Anderson ME, Braun AP, Wu Y, Lu T, Wu Y, Schulman H, Sung RJ: KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther 1998; 287:996-1006
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 996-1006
    • Anderson, M.E.1    Braun, A.P.2    Wu, Y.3    Lu, T.4    Wu, Y.5    Schulman, H.6    Sung, R.J.7


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