Airway hyperresponsiveness is negatively associated with obesity or overweight status in patients with asthma

International Archives of Allergy and Immunology

Volumn 159, Issue 2, 2012, Pages 187-193

  Kwon, Jae Woo ^a,b   Kim, Sae Hoon ^a,b   Kim, Tae Bum ^c   Kim, Sang Heon ^d   Park, Heung Woo ^a   Chang, Yoon Seok ^a,b   Jang, An Soo ^e   Cho, You Sook ^c   Nahm, Dong Ho ^f   Park, Jung Won ^g   Yoon, Ho Joo ^d   Cho, Young Joo ^h   Choi, Byoung Whui ⁱ   Moon, Hee Bom ^c   Cho, Sang Heon ^a  

^a Seoul National University   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

^d Hanyang University   (South Korea)

^e Soonchunhyang University   (South Korea)

^f Ajou University School of Medicine   (South Korea)

^g Yonsei University College of Medicine   (South Korea)

^h Ewha Womans University School of Medicine   (South Korea)

ⁱ Chung Ang University   (South Korea)

Author keywords

Asthma; Bronchial hyperreactivity; Obesity

Indexed keywords

METHACHOLINE;

ADULT; ARTICLE; ASTHMA; BODY MASS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; OBESITY; PREVALENCE; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY TRACT ALLERGY; SMOKING; WHEEZING;

ADULT; AGED; ASTHMA; BODY MASS INDEX; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; REPUBLIC OF KOREA; RESPIRATORY FUNCTION TESTS; RESPIRATORY SOUNDS; RISK FACTORS; THINNESS; YOUNG ADULT;

EID: 84861833332     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000335926     Document Type: Article

References (29)

1. Weiss ST, Shore S: Obesity and asthma: directions for research. Am J Respir Crit Care Med 2004; 169: 963-968.
2. Schachter LM, Salome CM, Peat JK, Woolcock AJ: Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 2001; 56: 4-8.
3. Beuther DA, Sutherland ER: Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007; 175: 661-666.
4. Litonjua AA, Sparrow D, Celedon JC, De-Molles D, Weiss ST: Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study. Thorax 2002; 57: 581-585.
5. Shore SA: Obesity, airway hyperresponsiveness, and inflammation. J Appl Physiol 2010; 108: 735-743.
6. Celedon JC, Palmer LJ, Litonjua AA, Weiss ST, Wang B, Fang Z, Xu X: Body mass index and asthma in adults in families of subjects with asthma in Anqing, China. Am J Respir Crit Care Med 2001; 164: 1835-1840.
7. Chinn S, Jarvis D, Burney P: Relation of bronchial responsiveness to body mass index in the European Community Respiratory Health Survey. Thorax 2002; 57: 1028-1033.
8. Nicolacakis K, Skowronski ME, Coreno AJ, West E, Nader NZ, Smith RL, McFadden ER Jr: Observations on the physiological interactions between obesity and asthma. J Appl Physiol 2008; 105: 1533-1541.
9. Sood A, Verhulst SJ, Varma A, Eagleton LE, Henkle JQ, Hopkins-Price P: Association of excess weight and degree of airway responsiveness in asthmatics and non-asthmatics. J Asthma 2006; 43: 447-452.
10. Salome CM, Munoz PA, Berend N, Thorpe CW, Schachter LM, King GG: Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects. Int J Obes (Lond) 2008; 32: 502-509.
11. Bustos P, Amigo H, Oyarzun M, Rona RJ: Is there a causal relation between obesity and asthma? Evidence from Chile. Int J Obes (Lond) 2005; 29: 804-809.
12. Van Veen IH, Ten Brinke A, Sterk PJ, Rabe KF, Bel EH: Airway inflammation in obese and nonobese patients with difficult-to-treat asthma. Allergy 2008; 63: 570-574.
13. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH: Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178: 218-224.
14. Johnston RA, Zhu M, Rivera-Sanchez YM, Lu FL, Theman TA, Flynt L, Shore SA: Allergic airway responses in obese mice. Am J Respir Crit Care Med 2007; 176: 650-658.
15. Kim TB, Park CS, Bae YJ, Cho YS, Moon HB: Factors associated with severity and exacerbation of asthma: a baseline analysis of the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA). Ann Allergy Asthma Immunol 2009; 103: 311-317.
16. Min KU, Kim YK, Park HS, Lee MH, Lee BJ, Son JW, Kim YY, Cho SH: Bronchial responsiveness to methacholine is increased in citrus red mite ( Panonychus citri )-sensitive children without asthmatic symptoms. Clin Exp Allergy 2000; 30: 1129-1134.
17. James PT: Obesity: The worldwide epidemic. Clin Dermatol 2004; 22: 276-280.
18. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ: Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31: 143-178.
19. Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, Casale TB, Chanez P, Enright PL, Gibson PG, de Jongste JC, Kerstjens HA, Lazarus SC, Levy ML, O'Byrne PM, Partridge MR, Pavord ID, Sears MR, Sterk PJ, Stoloff SW, Szefler SJ, Sullivan SD, Thomas MD, Wenzel SE, Reddel HK: A new perspective on concepts of asthma severity and control. Eur Respir J 2008; 32: 545-554.
20. Chapman DG, Berend N, King GG, Salome CM: Increased airway closure is a determinant of airway hyperresponsiveness. Eur Respir J 2008; 32: 1563-1569.
21. Aaron SD, Fergusson D, Dent R, Chen Y, Vandemheen KL, Dales RE: Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 2004; 125: 2046-2052.
22. Johnston RA, Theman TA, Lu FL, Terry RD, Williams ES, Shore SA: Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. J Appl Physiol 2008; 104: 1727-1735.
23. Johnston RA, Theman TA, Shore SA: Augmented responses to ozone in obese carboxypeptidase E-deficient mice. Am J Physiol Regul Integr Comp Physiol 2006; 290: R126-R133.
24. Sin DD, Sutherland ER: Obesity and the lung. 4. Obesity and asthma. Thorax 2008; 63: 1018-1023.
25. Ford ES: The epidemiology of obesity and asthma. J Allergy Clin Immunol 2005; 115: 897-910.
26. Meurs H, Gosens R, Zaagsma J: Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models. Eur Respir J 2008; 32: 487-502.
27. Busse WW: The relationship of airway hyperresponsiveness and airway inflammation: airway hyperresponsiveness in asthma: Its measurement and clinical significance. Chest 2010; 138: 4S-10S.
28. Shore SA: Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 2008; 121: 1087-1093.
29. Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA: Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 2005; 115: 103-109.