Scaffoldless Tissue Engineering of Stem Cell Derived Cavernous Tissue for Treatment of Erectile Function

Journal of Sexual Medicine

Volumn 9, Issue 6, 2012, Pages 1522-1534

  Orabi, Hazem ^a,b   Lin, Guiting ^a   Ferretti, Ludovic ^a,c   Lin, Ching Shwun ^a   Lue, Tom F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Assiut University Faculty of Medicine   (Egypt)

^c UPRES 4122   (France)

Author keywords

Adipose derived stem cells; Cavernous tissue; Cell sheets; Erectile dysfunction treatment; Stem cells; Tissue engineering

Indexed keywords

CALPONIN; COLLAGEN; ENDOTHELIAL CELL ANTIBODY;

ADIPOSE TISSUE DERIVED STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS CAVERNOSUM; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; EXTRACELLULAR MATRIX; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; STEM CELL; TISSUE ENGINEERING; WESTERN BLOTTING;

EID: 84861825247     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02727.x     Document Type: Article

References (40)

1. NIH consensus conference. Impotence. NIH consensus development panel on impotence. JAMA 1993;270:83-90.
2. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
3. Hatzimouratidis K, Hatzichristou DG. A comparative review of the options for treatment of erectile dysfunction: Which treatment for which patient? Drugs 2005;65:1621-50.
4. Smith IA, McLeod N, Rashid P. Erectile dysfunction-When tablets don't work. Aust Fam Physician 2010;39:301-5.
5. Harraz A, Shindel AW, Tom FL. Emerging gene and stem cell therapies for the treatment of erectile dysfunction. Nat Rev Urol 2010;7:143-52.
6. Hellstrom WJ, Montague DK, Moncada I, Carson C, Minhas S, Faria G, Krishnamurti S. Implants, mechanical devices, and vascular surgery for erectile dysfunction. J Sex Med 2010;7(1 Pt 2):501-23.
7. Burnett AL. Erectile dysfunction management for the future. J Androl 2009;30:391-6.
8. Deng W. Bivalacqua TJ, Hellstrom WJ, Kadowitz PJ. Gene and stem cell therapy for erectile dysfunction. Int J Impot Res 2005;17(1 suppl):S57-63.
9. Kwon TG, Yoo JJ, Atala A. Autologous penile corpora cavernosa replacement using tissue engineering techniques. J Urol 2002;168:1754-8.
10. Falke G, Yoo JJ, Kwon TG, Moreland R, Atala A. Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices. Tissue Eng 2003;9:871-9.
11. Chen K-L, Eberli D, Yoo JJ, Atala A. Bioengineered corporal tissue for structural and functional restoration of the penis. Proc Natl Acad Sci U S A 2010;107:3346-50.
12. Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, Lue TF. The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int 2004;94:904-9.
13. Bivalacqua TJ, Deng W, Kendirci M, Usta MF, Robinson C, Taylor BK, Murthy SN, Champion HC, Hellstrom WJ, Kadowitz PJ. Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Am J Physiol Heart Circ Physiol 2007;292:H1278-90.
14. Qiu X, Lin H, Wang Y, Yu W, Chen Y, Wang R, Dai Y. Intracavernous transplantation of bone marrow-derived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats. J Sex Med 2011;8:427-36.
15. Nolazco G, Kovanecz I, Vernet D, Gelfand RA, Tsao J, Ferrini MG, Magee T, Rajfer J, Gonzalez-Cadavid NF. Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int 2008;101:1156-64.
16. Garcia MM, Fandel TM, Lin G, Shindel AW, Banie L, Lin CS, Lue TF. Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. J Sex Med 2010;7:89-98.
17. Huang YC, Ning H, Shindel AW, Fandel TM, Lin G, Harraz AM, Lue TF, Lin CS. The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model. J Sex Med 2010;7(1 Pt 1):1391-400.
18. Schmeisser A, Strasser RH. Phenotypic overlap between hematopoietic cells with suggested angioblastic potential and vascular endothelial cells. J Hematother Stem Cell Res 2002;11:69-70.
19. Foresta C, Caretta N, Lana A, Cabrelle A, Palù G, Ferlin A. Circulating endothelial progenitor cells in subjects with erectile dysfunction. Int J Impot Res 2005;17:288-90.
20. Albersen M, Fandel TM, Lin GT, Wang G, Banie L, Lin CS, Lue TF. Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 2010;7:3331-40.
21. Gimble JM. Adipose tissue-derived therapeutics. Expert Opin Biol Ther 2003;3:705-13.
22. Lin G, Banie L, Ning H, Bella AJ, Lin C-S, Lue TF. Potential of adipose-derived stem cells for treatment of erectile dysfunction. J Sex Med 2009;6(3 suppl):320-7.
23. Lin G, Garcia M, Ning H, Banie L, Gio YL, Lue TF, Lin CS. Defining stem and progenitor cells within adipose tissue. Stem Cells Dev 2008;17:1053-63.
24. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV, March KL. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004;109:1292-8.
25. Bahk JY, Jung JH, Han H, Min SK, Lee YS. Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: Preliminary report of 7 cases. Exp Clin Transplant 2010;8:150-60.
26. Lin G, Banie L, Ning H, Bella AJ, Lin C-S, Tom FL. Fibroblast growth factor 2 promotes endothelial differentiation of adipose tissue-derived stem cells. J Sex Med 2009;6:967-79.
27. Harris LJ, Abdollahi H, Zhang P, McIlhenny S, Tulenko TN, DiMuzio PJ. Differentiation of adult stem cells into smooth muscle for vascular tissue engineering. J Surg Res 2011;168:306-14.
28. Basu J, Genheimer C, Guthrie KI, Sangha N, Quinlan SF, Bruce AT, Reavis B, Halberstadt CR, Ilagan R, Ludlow JW. Expansion of the human adipose-derived stromal vascular cell fraction yields a population of smooth muscle-like cells with markedly distinct phenotypic and functional properties relative to mesenchymal stem cells. Tissue Eng Part C Methods 2011; 17:843-60.
29. Ning H, Liu G, Lin G, Garcia M, Li L-C, Lue TF, Ching-Shwun L. Identification of an aberrant cell line among human adipose tissue-derived stem cell isolates. Differentiation 2009; 77:172-80.
30. Lin G, Qiu X, Fandel TM, Banie L, Wang G, Lue TF, Lin CS. Tracking intracavernously injected adipose-derived stem cells to bone marrow. Int J Impot Res 2011;23:268-75.
31. Fandel TM, Albersen M, Qiu X, Lin G, Lue TF, Lin CS. Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous-nerve injury. Eur Urol 2012;61:201-10.
32. Khoshnoodi J, Pedchenko V, Hudson BG. Mammalian collagen IV. Microsc Res Tech 2008;71:357-70.
33. Le Visage C, Gournay O, Benguirat N, Hamidi S, Chaussumier L, Mougeneot N, Flanders JA, Isnard R, Michel JB, Hatem S, Letourneur D, Norol F. Mesenchymal stem cell delivery into rat infarcted myocardium using a porous polysaccharide-based scaffold: A quantitative comparison with endocardial injection. Tissue Eng Part A 2012;18:35-44.
34. Altman AM, Matthias N, Yan Y, Song Y-H, Bai X, Chiu ES, Slakey DP, Alt EU. Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells. Biomaterials 2008;29:1431-42.
35. Kang SW, Seo SW, Choi CY, Kim BS. Porous poly(lactic-co-glycolic acid) microsphere as cell culture substrate and cell transplantation vehicle for adipose tissue engineering. Tissue Eng Part C Methods 2008;14:25-34.
36. Christ GJ. The penis as a vascular organ. The importance of corporal smooth muscle tone in the control of erection. Urol Clin North Am 1995;22:727-45.
37. Costa C, Virag R. The endothelial-erectile dysfunction connection: An essential update. J Sex Med 2009;6:2390-404.
38. Musicki B, Burnett AL. Endothelial dysfunction in diabetic erectile dysfunction. Int J Impot Res 2007;19:378-85.
39. Jack GS, Almeida FG, Zhang R, Alfonso ZC, Zuk PA, Rodríguez LV. Processed lipoaspirate cells for tissue engineering of the lower urinary tract: Implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol 2005;174:2041-5.
40. Singec I, Jandial R, Crain A, Nikkhah G, Snyder EY. The leading edge of stem cell therapeutics. Annu Rev Med 2007; 58:313-28.