A phase II, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate in patients with rheumatoid arthritis

Arthritis and Rheumatism

Volumn 64, Issue 6, 2012, Pages 1730-1739

  Yellin, Michael ^a,i   Paliienko, Igor ^b   Balanescu, Andra ^c   Ter Vartanian, Semen ^d   Tseluyko, Vira ^e   Xu, Li An ^f   Tao, Xiaolu ^f   Cardarelli, Pina M ^f   Leblanc, Heidi ^f   Nichol, Geoff ^a,j   Ancuta, Codrina ^g   Chirieac, Rodica ^h   Luo, Allison ^f  

^a MEDAREX INC   (United States)

^b BOGOMOLETS NATIONAL MEDICAL UNIVERSITY   (Ukraine)

^c St Maria Clinical Hospital   (Romania)

^d Kiev Central Municipal Clinical Hospital   (Ukraine)

^e City Clinical Hospital No 8   (Ukraine)

^f BRISTOL MYERS SQUIBB   (United States)

^g GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^h Clinical Rehabilitation Hospital   (Romania)

ⁱ Celldex Therapeutics Inc   (United Kingdom)

^j SANGAMO BIOSCIENCES INC   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MDX 1100; METHOTREXATE; MONOCLONAL ANTIBODY; PLACEBO; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC RHINITIS; ANEMIA; ARTICLE; ASTHENIA; BRONCHOSPASM; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FATALITY; DRUG FEVER; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HUMAN; HYPERTHERMIA; HYPERTRANSAMINASEMIA; INFECTION; LYMPHOCYTE COUNT; MALE; NEUTROPHIL COUNT; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SIDE EFFECT; TREATMENT RESPONSE;

ADULT; AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CHEMOKINE CXCL10; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84861816840     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34330     Document Type: Article

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