Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: A proton magnetic resonance spectroscopy study

Journal of Psychopharmacology

Volumn 26, Issue 5, 2012, Pages 733-737

  Taylor, Matthew J ^a   Tiangga, Eleanor R ^a   Mhuircheartaigh, Roísín Ní ^b   Cowen, Philip J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Glutamate; ketamine; magnetic resonance spectroscopy

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; KETAMINE;

ADULT; ARTICLE; BRAIN LEVEL; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; HUMAN EXPERIMENT; LOW DRUG DOSE; MALE; MENTAL HEALTH; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADULT; CEREBRAL CORTEX; DEPRESSIVE DISORDER, MAJOR; FEMALE; GLUTAMIC ACID; GLUTAMINE; HUMANS; KETAMINE; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTONS; YOUNG ADULT;

EID: 84861814934     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881111405359     Document Type: Article

References (22)

1. Auer DP, Pütz B, Kraft E, Lipinski B, Schill J, Holsboer F. Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry. 2000 ; 47: 305-313
2. Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000 ; 47: 351-354
3. Bhagwagar Z, Wylezinska M, Jezzard P, et al. Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients. Int J Neuropsychopharmacol. 2008 ; 11: 255-260
4. Corlett PR, Honey GD, Aitken MR, et al. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis. Arch Gen Psychiatry. 2006 ; 63: 611-21
5. Diazgranados N, Ibrahim L, Brutsche NE, et al. A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch Gen Psychiatry. 2010 ; 67: 793-802
6. First MB, Spitzer RL, Gibbon M, Williams JBW Structured Clinical Interview for DSM-IV Axis I disorders-Clinician Version (SCID-CV). Washington, DC: American Psychiatric Press ; 1997 :
7. Hasler G, Neumeister A, van der Veen JW, et al. Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biol Psychiatry. 2005 ; 58: 969-973
8. Hasler G, van der Veen JW, Tumonis T, Meyers N, Shen J, Drevets WC. Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 2007 ; 64: 193-200
9. Homayoun H, Moghaddam B. NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons. J Neurosci. 2007 ; 27: 11,496-11,500
10. Hurd R, Sailasuta N, Srinivasan R, Vigneron DB, Pelletier D, Nelson SJ. Measurement of brain glutamate using TE-averaged PRESS at 3T. Magn Reson Med. 2004 ; 51: 435-440
11. Krystal JH, Karper LP, Seibyl JP, et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry. 1994 ; 51: 199-214
12. Mason O, Claridge G. The Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE): further description and extended norms. Schiz Res. 2006 ; 82: 203-211
13. McLean MA, Barker GJ. Concentrations and magnetization transfer ratios of metabolites in gray and white matter. Magn Reson Med. 2006 ; 56: 1365-1370
14. Moghaddam B, Adams B, Verma A, Daly D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 1997 ; 17: 2921-2927
15. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed. 2001 ; 14: 260-264
16. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schiz Bull. 1991 ; 17: 555-564
17. Raininko R, Mattsson P. Metabolite concentrations in supraventricular white matter from teenage to early old age: a short echo time1H magnetic resonance spectroscopy (MRS) study. Acta Radiol. 2010 ; 51: 309-315
18. Rowland LM, Bustillo JR, Mullins PG, et al. Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study. Am J Psychiatry. 2005 ; 162: 394-396
19. Taylor MJ, Selvaraj S, Norbury R, Jezzard P, Cowen PJ. Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients. J Affect Dis. 2009 ; 119: 186-189
20. Vanhamme , van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson. 1997 ; 129: 35-43
21. Zarate CA, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006 ; 63: 856-864
22. Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imag. 2001 ; 20: 45-57