Cytotoxicity evaluation of marine alkaloid analogues of viscosaline and theonelladin C

Biomedicine and Preventive Nutrition

Volumn 2, Issue 2, 2012, Pages 145-148

  Pereira, Juliana R C S ^a   Hilário, Flaviane F ^b   Lima, Aline B ^a   Silveira, Mariana L T ^b   Silva, Luciana M ^c   Alves, Rosemeire B ^b   de Freitas, Rossimiriam P ^b   Varotti, Fernando P ^a   Viana, Gustavo H R ^a  

^a FEDERAL UNIVERSITY OF SÃO JOÃO DEL REI   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

Author keywords

Antitumoral; Chemical modification; Marine alkaloid analogues

Indexed keywords

CYTOTOXIC AGENT; ETOPOSIDE; THEONELLADIN C; UNCLASSIFIED DRUG; VISCOSALINE;

ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NICK END LABELING; PRIORITY JOURNAL;

EID: 84861810769     PISSN: 22105239     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bionut.2012.01.003     Document Type: Article

References (22)

1. WHO. Accessed on 21 June, 2011. http://www.who.int/features/factfiles/cancer/en/index.html.
2. MacKie R.M., Hauschild A., Eggermont A.M.M. Epidemiology of invasive cutaneous melanoma. Ann Oncol 2009, 20:1-7.
3. Vidwans S.J., Flaherty K.T., Fisher D.E., Tenenbaum J.M., Travers M.D., Shrager J. A melanoma molecular disease model. PloS One 2011, 6:e18257.
4. Kemp Z., Thirlwell C., Sieber O., Silver A., Tomlinson I. An update on the genetics of colorectal cancer. Hum Mol Genet 2004, 13:R177-R185.
5. Harrison S., Benziger H. The molecular biology of colorectal carcinoma and its implications: a review. Surg 2011, 9:200-210.
6. Sugumaran M., Robinson W.E. Bioactive dehydrotyrosyl and dehydrodopyl compounds of marine origin. Mar Drugs 2010, 8:2906-2935.
7. Sipkema D., Franssen M.C.R., Osinga R., Tramper J., Wijffels R.H. Marine sponges as pharmacy. Mar Biotechnol 2005, 7:142-162.
8. Newman D.J., Cragg G.M. Advanced preclinical and clinical trials of natural products and related compounds from marine sources. Curr Med Chem 2004, 11:1693-1713.
9. Grube A., Timm C., Kock M. Synthesis and mass spectrometric analysis of cyclostellettamines H, I, K and L. Eur J Org Chem 2006, 1285-1295.
10. Almeida A.M.P., Berlinck R.G.S., Hajdu E. Alkylpyridine alkaloids from marine sponges. Quim Nova 1997, 20:170-185.
11. Sepcic K. Bioactive alkylpyridinium compounds from marine sponges. J Toxicol Toxin Rev 2000, 19:139-160.
12. Timm C., Kock M. First total synthesis of the marine natural product viscosamine. Synthesis-Stuttgart 2006, 2580-2584.
13. Blunt J.W., Copp B.R., Munro M.H.G., Northcote P.T., Prinsep M.R. Marine natural products. Nat Prod Rep 2010, 27:165-237.
14. Kura K., Kubota T., Fromont J., Kobayashi J. Pyrinodemins E and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp. Bioorg Med Chem Lett 2011, 21:267-270.
15. Volk C.A., Kock M. Viscosaline: new 3-alkyl pyridinium alkaloid from the Arctic sponge Haliclona viscosa. Org Biomol Chem 2004, 2:1827-1830.
16. Kobayashi J., Murayama T., Ohizumi Y. Theonelladins A~D, novel antineoplasic pyridine alkaloids from the okinawan marine sponge Theonella-swinhoei. Tetrahedron Lett 1989, 30:4833-4836.
17. Maia A.A., Mons S., Gil R.P.D., Marazano C. Synthesis of the unusual octahydropyrano 2,3-b pyridine ring system of upenamide. Eur J Org Chem 2004, 1057-1062.
18. Hilário F.F., de Paula R.C., Silveira M.L., Viana G.H.R., Alves R.B., Pereira J.R., et al. Synthesis and evaluation of antimalarial activity of oxygenated 3-alkylpyridine marine alkaloid analogues. Chem Bio Drug Des 2011, 78:477-482.
19. Essack M., Bajic V.B., Archer J.A.C. Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment. Mar Drugs 2011, 9:1580-1606.
20. Darzynkiewicz Z., Galkowski D., Zhao H. Analysis of apoptosis by cytometry using TUNEL assay. Methods 2008, 44:250-254.
21. Correale P., Botta C., Basile A., Pagliuchi M., Licchetta A., Martellucci I., et al. Phase II trial of bevacizumab and dose/dense chemotherapy with cisplatin and metronomic daily oral etoposide in advanced non-small-cell-lung cancer patients. Cancer Biol Ther 2011, 12:112-118.
22. Liu J., Uematsu H., Tsuchida N., Ikeda M.A. Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer 2011, 10:95.