In utero and lactational exposure to low-dose genistein-vinclozolin mixture affects the development and growth factor mRNA expression of the submandibular salivary gland in immature female rats

Toxicologic Pathology

Volumn 40, Issue 4, 2012, Pages 593-604

  Kouidhi, Wided ^a,b   Desmetz, Catherine ^b   Nahdi, Afef ^a   Bergès, Raymond ^b   Cravedi, Jean Pierre ^c   Auger, Jacques ^d   May, Michèle El ^a   Canivenc Lavier, Marie Chantal ^b  

^a UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

^b CENTRE DES SCIENCES DU GOÛT ET DE L ALIMENTATION   (France)

^c TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^d Institut Cochin   (France)

Author keywords

dietary exposure; endocrine disruptor; female offspring; morphogenesis; phytoestrogen; salivary glands

Indexed keywords

EPIDERMAL GROWTH FACTOR; GENISTEIN; MESSENGER RNA; NERVE GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA; VINCLOZOLIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; FEMALE; GENE EXPRESSION; LACTATION; MORPHOGENESIS; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBMANDIBULAR GLAND;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CELL PROLIFERATION; DIET; DRUG COMBINATIONS; EATING; ENDOCRINE DISRUPTORS; ENVIRONMENTAL EXPOSURE; FEMALE; GENISTEIN; LACTATION; MALE; MATERNAL EXPOSURE; OXAZOLES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; RECEPTORS, GROWTH FACTOR; RECEPTORS, STEROID; RNA, MESSENGER; SALIVARY GLANDS;

RATTUS;

EID: 84861806765     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623311436183     Document Type: Article

References (49)

1. Actis A. B.. A hypothesis to relate salivary tumors with mammary and prostate neoplasias. Bioinformation. 2005 ; 1: 12-13
2. AFSSA-AFSSAPS. (2005). The safety and benefits of dietary phytoestrogens-Recommandations. AFSSA, AFSSAPS, editors. Maisons-Alfort, Saint-Denis (France). http://www.afssa.fr/Documents/NUT-Ra-Phytoestrogenes.pdf.
3. AugerJ.Canivenc-LavierM. C.Perrot-ApplanatM.HabertR.SavouretJ.-F. CravediJ. P. (2010). Gestational and postnatal exposures to dietary low doses of genistein and/or vinclozolin in rodents: Effects at different developmental steps, modes of action, compounds fate and biotransformation in various organs and tissues. [abstract]. Colloque PNR-PE. April 12, 2010, Rennes, France. http://pnrpe.fr/IMG/pdf/Resume-Auger-Anglais.pdf
4. Boyer R., Jame F., Arancibia S.. A non-exocrine function of the submaxillary gland [article in French]. Ann Endocrinol (Paris). 1991 ; 52: 307-22
5. Brown N. M., Wang J., Cotroneo M. S., Zhao Y. X., Lamartiniere C. A.. Prepubertal genistein treatment modulates TGF-alpha, EGF and EGF-receptor mRNAs and proteins in the rat mammary gland. Mol Cell Endocrinol. 1998 ; 144: 149-65
6. Buckley J., Willingham E., Agras K., Baskin L. S.. Embryonic exposure to the fungicide vinclozolin causes virilization of females and alteration of progesterone receptor expression in vivo: an experimental study in mice. Environ Health. 2006 ; 5: 4
7. Bursztyka J., Debrauwer L., Perdu E., Jouanin I., Jaeg J. P., Cravedi J. P.. Biotransformation of vinclozolin in rat precision-cut liver slices: comparison with in vivo metabolic pattern. J Agric Food Chem. 2008 ; 56: 4832-39
8. Campbell P. S., Ben-Aryeh H., Swanson K. A.. Differential distribution of an estrogen receptor in the submandibular and parotid salivary glands of female rats. Endocr Res. 1990 ; 16: 333-45
9. Carvalho V. D., Silveira V. A., do Prado R. F., Carvalho Y. R.. Effect of estrogen therapy, soy isoflavones, and the combination therapy on the submandibular gland of ovariectomized rats. Pathol Res Pract. 2011 ; 207: 300-5
10. De Rijk E. P., Ravesloot W. T., Hafmans T. G., van Esch E.. Multifocal ductal cell hyperplasia in the submandibular salivary glands of Wistar rats chronically treated with a novel steroidal compound. Toxicol Pathol. 2003 ; 31: 1-9
11. El Sheikh Saad H., Meduri G., Phrakonkham P., Berges R., Vacher S., Djallali M., Auger J., Canivenc-Lavier M. C., Perrot-Applanat M.. Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food contaminant vinclozolin. Reprod Toxicol. 2011 ; 32: 15-25
12. 2008 Annual Report on Pesticide Residues according to Article 32 of Regulation (EC) No 396/2005. EFSA Journal. 2010 ; 8: 1646
13. Eustache F., Mondon F., Canivenc-Lavier M. C., Lesaffre C., Fulla Y., Berges R., Cravedi J. P., Vaiman D., Auger J.. Chronic dietary exposure to a low-dose mixture of genistein and vinclozolin modifies the reproductive axis, testis transcriptome, and fertility. Environ Health Perspect. 2009 ; 117: 1272-79
14. Flynn E. A., Yelland K. T., Shklar G.. Effect of estradiol on ultrastructure of granular ducts in submandibular glands of female rats. Anat Rec. 1983 ; 206: 23-30
15. Gresik E. W.. Postnatal developmental changes in submandibular glands of rats and mice. J Histochem Cytochem. 1980 ; 28: 860-70
16. Hayashi H., Ozono S., Watanabe K., Nagatsu I., Onozuka M.. Morphological aspects of the postnatal development of submandibular glands in male rats: involvement of apoptosis. J Histochem Cytochem. 2000 ; 48: 695-98
17. Hiramatsu M., Kashimata M., Takayama F., Minami N.. Developmental changes in and hormonal modulation of epidermal growth factor concentration in the rat submandibular gland. J Endocrinol. 1994 ; 140: 357-63
18. Houssay A. B., de Harfin J. F.. Effects of estrogens on submaxillary glands in mice. J Dent Res. 1973 ; 52: 1051-53
19. Humpel C., Lindqvist E., Olson L.. Detection of nerve growth factor mRNA in rodent salivary glands with digoxigenin- and 33P-labeled oligonucleotides: effects of castration and sympathectomy. J Histochem Cytochem. 1993 ; 41: 703-8
20. Hwang D. L., Wang S., Chen R. C., Lev-Ran A.. Trauma, especially of the submandibular glands, causes release of epidermal growth factor into bloodstream in mice. Regul Pept. 1991 ; 34: 133-39
21. Islander U., Hasseus B., Erlandsson M. C., Jochems C., Skrtic S. M., Lindberg M., Gustafsson J. A., Ohlsson C., Carlsten H.. Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands. BMC Immunol. 2005 ; 6: 16
22. Jacoby F., Leeson C. R.. The postnatal development of the rat submaxillary gland. J Anat. 1959 ; 93: 201-16
23. Katsukawa H., Tanabe Y., Funakoshi M.. Effects of androgens on the activity of steroid-metabolizing enzymes in the murine submaxillary gland. J Dent Res. 1983 ; 62: 725-27
24. Laine M., Leimola-Virtanen R.. Effect of hormone replacement therapy on salivary flow rate, buffer effect and pH on perimenopausal and postmenopausal women. Arch Oral Biol. 1996 ; 41: 91-96
25. Lehraiki A., Messiaen S., Berges R., Canivenc-Lavier M. C., Auger J., Habert R., Levacher C.. Antagonistic effects of gestational dietary exposure to low-dose vinclozolin and genistein on rat fetal germ cell development. Reprod Toxicol. 2011 ; 31: 424-30
26. Mathison R.. The Submandibular Glands: a role in homeostasis and allostasis. Biomed Rev. 1995 ; 4: 61-69
27. Matsuura I., Saitoh T., Ashina M., Wako Y., Iwata H., Toyota N., Ishizuka Y., Namiki M., Hoshino N., Tsuchitani M. Evaluation of a two-generation reproduction toxicity study adding endpoints to detect endocrine disrupting activity using vinclozolin. J Toxicol Sci. 2005 ; 30: 163-88
28. Miyaji Y., Aiyama S., Kurabuchi S.. Strain-specific and endocrine control of granular convoluted tubule cells and epidermal growth factor expression in the mouse submandibular gland. Anat Rec (Hoboken). 2008 ; 291: 105-13
29. Mogi M., Matsuura S., Suzuki K., Inagaki H., Minami M., Kojima K., Harada M.. Differential expression of transforming growth factor-alpha and epidermal growth factor during postnatal development of rat submandibular gland. Biochem Biophys Res Commun. 1995 ; 217: 271-77
30. Molina-Molina J. M., Hillenweck A., Jouanin I., Zalko D., Cravedi J. P., Fernandez M. F., Pillon A., Nicolas J. C., Olea N., Balaguer P.. Steroid receptor profiling of vinclozolin and its primary metabolites. Toxicol Appl Pharmacol. 2006 ; 216: 44-54
31. Morris-Wiman J., Sego R., Brinkley L., Dolce C.. The effects of sialoadenectomy and exogenous EGF on taste bud morphology and maintenance. Chem Senses. 2000 ; 25: 9-19
32. Mylchreest E., Cattley R. C., Foster P. M.. Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism?. Toxicol Sci. 1998 ; 43: 47-60
33. Ozono S., Onozuka M., Sato K., Ito Y.. Immunohistochemical evidence for the presence of progesterone receptor in rat submandibular glands. Cell Struct Funct. 1991 ; 16: 511-13
34. Pfaffl M. W.. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001 ; 29: e45
35. Porola P., Laine M., Virkki L., Poduval P., Konttinen Y. T.. The influence of sex steroids on Sjogren's syndrome. Ann N Y Acad Sci. 2007 ; 1108: 426-32
36. Rins de David M. L., Caceres A., Goldraij A.. Sexual dimorphism in rat submaxillary gland [article in Spanish]. Acta Odontol Latinoam. 1990 ; 5: 63-9
37. Rougeot C., Rosinski-Chupin I., Mathison R., Rougeon F.. Rodent submandibular gland peptide hormones and other biologically active peptides. Peptides. 2000 ; 21: 443-55
38. Sakabe K., Onoe M., Okuma M., Yoshida T., Aikawa H., Kinoue T., Kayama F.. Natural and environmental oestrogens increase expression of SS-A/Ro autoantigen in the salivary gland of ovariectomized immature rats. Pathophysiology. 2000 ; 6: 231-36
39. Saruta J., Sato S., Tsukinoki K.. The role of neurotrophins related to stress in saliva and salivary glands. Histol Histopathol. 2010 ; 25: 1317-30
40. Sawada K., Noumura T.. Effects of castration and sex steroids on sexually dimorphic development of the mouse submandibular gland. Acta Anat (Basel). 1991 ; 140: 97-103
41. Siminoski K., Bernanke J., Murphy R. A.. Nerve growth factor and epidermal growth factor in mouse submandibular glands: identical diurnal changes and rates of secretagogue-induced synthesis. Endocrinology. 1993 ; 132: 2031-37
42. Stroheker T., Chagnon M. C., Pinnert M. F., Berges R., Canivenc-Lavier M. C.. Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: a comparative study. Reprod Toxicol. 2003 ; 17: 421-32
43. Suzuki Y., Mizoguchi I., Uchida N.. Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization. Arch Histol Cytol. 2007 ; 70: 117-26
44. Treister N. S., Richards S. M., Suzuki T., Jensen R. V., Sullivan D. A. Influence of androgens on gene expression in the BALB/c mouse submandibular gland. J Dent Res. 2005 ; 84: 1187-92
45. Tuomela T., Miettinen P., Pesonen K., Viinikka L., Perheentupa J.. Epidermal growth factor in mice: effects of estradiol, testosterone and dexamethasone. Acta Endocrinol (Copenh). 1990 ; 123: 211-17
46. Vinclozolin; notice of filing a pesticide petition to establish a tolerance for a certain pesticide chemical in or on food. Fed Reg. 2003 ; 68: 14628-35
47. White S. C., Mudd B. D.. Hormonal regulation of submandibular salivary gland morphology and antigenicity in rats. Arch Oral Biol. 1975 ; 20: 871-75
48. Wong C., Kelce W. R., Sar M., Wilson E. M.. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J Biol Chem. 1995 ; 270: 19998-20003
49. Xu Q. L. [The localization and potential function of androgen receptor mRNA in rat submaxillary]. Zhonghua Nan Ke Xue. 2003 ; 9: 681-83