Hemodynamic fluid shear stress response genes and carotid intima-media thickness: A candidate gene association analysis in the cardiovascular health study

International Journal of Molecular Epidemiology and Genetics

Volumn 3, Issue 2, 2012, Pages 174-178

  Suchy Dicey, Astrid M ^a,c   Enquobahrie, Daniel A ^a,c   Heckbert, Susan R ^a,c   Rotter, Jerome I ^b   Psaty, Bruce M ^a,c   Mcknight, Barbara ^a,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Candidate gene study; Cardiovascular health study (CHS); Carotid intima media thickness (cIMT); Endothelium endothelial cells; Fluid shear stress; Hemody namics response; Kruppel like factor 2 (KLF2); Mitogen activated protein kinase 7 (MAPK7); Mitogen activated protein kinase kinase 5 (MAP2K5); Myocyte specific enhancer factor 2 a c (MEF2A c)

Indexed keywords

KRUPPEL LIKE FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE 5; MYOCYTE ENHANCER FACTOR 2;

AGED; ALLELE; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEMODYNAMIC STRESS; HUMAN; MAJOR CLINICAL STUDY; MALE; SHEAR STRESS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84861767483     PISSN: None     EISSN: 19481756     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Hahn C and Schwartz MA. Mechanotransduc-tion in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol 2009; 10: 53-62.
2. Malek AM, Alper SL and Izumo S. Hemody-namic shear stress and its role in atherosclerosis. Jama-Journal of the American Medical Association 1999; 282: 2035-2042.
3. Parmar KM, Larman HB, Dai GH, Zhang YH, Wang ET, Moorthy SN, Kratz JR, Lin ZY, Jain MK, Gimbrone MA and Garcia-Cardena G. Integration of flow-dependent endothelial pheno-types by Kruppel-like factor 2. Journal of Clinical Investigation 2006; 116: 49-58.
4. Kato Y, Kravchenko VV, Tapping RI, Han JH, Ulevitch RJ and Lee JD. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. Embo Journal 1997; 16: 7054-7066.
5. Harrison DG, Widder J, Grumbach I, Chen W, Weber M and Searles C. Endothelial mecha-notransduction, nitric oxide and vascular inflammation. Journal of Internal Medicine 2006; 259: 351-363.
6. Groenendijk BCW, Van der Heiden K, Hierck BP and Poelmann RE. The role of shear stress on ET-1, KLF2, and NOS-3 expression in the developing cardiovascular system of chicken embryos in a venous Ligation model. Physiology 2007; 22: 380-389.
7. Hamsten A and Eriksson P. Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism. Journal of Internal Medicine 2008; 263: 538-552.
8. Bis JKM, Franceschini N, Isaacs A, Abecasis G, Homuth G, Cheng Y, Harris T, Demissie S, Rotter J, Witteman J, Nambi V, van Duijn C, Scuteri A, Schminke U, Post W, Gudnason V, O'Donnell C; on behalf of the CHARGE Consortium Carotid IMT Working Group. Genome-wide association studies of carotid intima-media thickness: Meta -analysis from the charge consortium. American Heart Association Council on Epidemiology and Prevention, Scientific Sessions. 2010
9. Fried LP BN, Enright P, Furberg CD, Gardin JM, Kronmal RA, Kuller LH, Manolio TA, Mittelmark MB, Newman A. The Cardiovascular Health Study: design and rationale. Annals of Epidemiology 1991; 1: 263-276.
10. Newton-Cheh C, Eijgelsheim M, Rice KM, de Bakker PIW, Yin XY, Estrada K, Bis JC, Marci-ante K, Rivadeneira F, Noseworthy PA, So-toodehnia N, Smith NL, Rotter JI, Kors JA, Witte-man JCM, Hofman A, Heckbert SR, O'Donnell CJ, Uitterlinden AG, Psaty BM, Lumley T, Larson MG and Stricker BHC. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nature Genetics 2009; 41: 399-406.
11. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK and Grp CHSCR. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. New England Journal of Medicine 1999; 340: 14-22.
12. Dudoit S, Shaffer JP and Boldrick JC. Multiple hypothesis testing in microarray experiments. Statistical Science 2003; 18: 71-103.
13. Ruczinski I, Kooperberg C and LeBlanc M. Logic regression. Journal of Computational and Graphical Statistics 2003; 12: 475-511.
14. Kooperberg C and Ruczinski I. Identifying interacting SNPs using Monte Carlo logic regression. Genetic Epidemiology 2005; 28: 157-170.
15. StataCorp. Stata statistical software: Release 8. Stata. 2003.
16. RDevelopmentCoreTeam. R: A language and environment for statistical computing. R. 2009.