The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop

Journal of Biological Chemistry

Volumn 287, Issue 23, 2012, Pages 19665-19673

  Haupt, Katja ^a,c   Jahreis, Günther ^a   Linnert, Miriam ^a   Maestre Martínez, Mitcheell ^a,d   Malešević, Miroslav ^a   Pechstein, Arndt ^a,e   Edlich, Frank ^a,b   Lücke, Christian ^a  

^a MAX PLANCK RESEARCH UNIT FOR ENZYMOLOGY OF PROTEIN FOLDING   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Research Institute of Leather and Plastic Sheeting FILK   (Germany)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING EPITOPES; CATALYTIC DOMAINS; CONTACT REGIONS; CONTACT SITES; HETERONUCLEAR; INTERMOLECULAR CONTACTS; KEY RESIDUES; MEMBRANE ASSAY; MOLECULAR MECHANISM; SITE DIRECTED MUTAGENESIS; STRUCTURAL INSIGHTS; STRUCTURE MODELS;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ELECTROSTATICS;

ARGININE; CALCIUM; FK 506 BINDING PROTEIN; PEPTIDYLPROLYL ISOMERASE; PROTEIN BCL 2; PROTEIN FKBP38; UNCLASSIFIED DRUG;

ALPHA HELIX; APOPTOSIS; ARTICLE; BINDING SITE; CATALYSIS; COMPLEX FORMATION; ENZYME ACTIVE SITE; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STATIC ELECTRICITY;

CALCIUM; EPITOPES; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE LIBRARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; TACROLIMUS BINDING PROTEINS;

EID: 84861746092     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.317214     Document Type: Article

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