Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of systemic autoimmune diseases

Autoimmunity Reviews

Volumn 11, Issue 9, 2012, Pages 642-645

  Mahler, Michael ^a   Hanly, John G ^b   Fritzler, Marvin J ^c  

^a INOVA DIAGNOSTICS INC   (United States)

^b DALHOUSIE UNIVERSITY   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

ANA; Autoimmune disease; DFS; LEDGF

Indexed keywords

ANTIGEN; ANTINUCLEAR ANTIBODY; DENSE FINE SPECKLES 70 ANTIGEN; UNCLASSIFIED DRUG;

ALGORITHM; ANTIBODY SPECIFICITY; AUTOIMMUNE DISEASE; HEP 2 CELL; HUMAN; IMMUNOADSORPTION; IMMUNOFLUORESCENCE; REVIEW; RHEUMATIC DISEASE; SAMPLING; SCREENING; SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALGORITHMS; ANTIBODIES, ANTINUCLEAR; AUTOIMMUNE DISEASES; FALSE POSITIVE REACTIONS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEP G2 CELLS; HUMANS; SENSITIVITY AND SPECIFICITY; STAINING AND LABELING; TRANSCRIPTION FACTORS;

EID: 84861744699     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2011.11.005     Document Type: Review

References (27)

1. Mahler M., Fritzler M.J. Epitope specificity and significance in systemic autoimmune diseases. Ann N Y Acad Sci 2010, 1183:267-287.
2. Op De B.K., Vermeersch P., Verschueren P., Westhovens R., Marien G., Blockmans D., et al. Detection of antinuclear antibodies by indirect immunofluorescence and by solid phase assay. Autoimmun Rev 2011, 10:801-808.
3. Plebani M., Pittoni M., Celadin M., Bernardi D., Mion M.M. Recent advances in diagnostic technologies for autoimmune diseases. Autoimmun Rev 2009, 8:238-243.
4. Meroni P.L., Schur P.H. ANA screening: an old test with new recommendations. Ann Rheum Dis 2010, 69:1420-1422.
5. Pisetsky D.S. Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?. Arthritis Res Ther 2011, 13:109.
6. Watanabe A., Kodera M., Sugiura K., Usuda T., Tan E.M., Takasaki Y., et al. Anti-DFS70 antibodies in 597 healthy hospital workers. Arthritis Rheum 2004, 50:892-900.
7. Fritzler M.J. The antinuclear antibody test: last or lasting gasp?. Arthritis Rheum 2011, 63:19-22.
8. Ochs R.L., Muro Y., Si Y., Ge H., Chan E.K., Tan E.M. Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. J Allergy Clin Immunol 2000, 105:1211-1220.
9. Ganapathy V., Casiano C.A. Autoimmunity to the nuclear autoantigen DFS70 (LEDGF): what exactly are the autoantibodies trying to tell us?. Arthritis Rheum 2004, 50:684-688.
10. Daniels T., Zhang J., Gutierrez I., Elliot M.L., Yamada B., Heeb M.J., et al. Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis. Prostate 2005, 62:14-26.
11. Dellavance A., Viana V.S., Leon E.P., Bonfa E.S., Andrade L.E., Leser P.G. The clinical spectrum of antinuclear antibodies associated with the nuclear dense fine speckled immunofluorescence pattern. J Rheumatol 2005, 32:2144-2149.
12. Yamada K., Senju S., Shinohara T., Nakatsura T., Murata Y., Ishihara M., et al. Humoral immune response directed against LEDGF in patients with VKH. Immunol Lett 2001, 78:161-168.
13. Ayaki M., Ohoguro N., Azuma N., Majima Y., Yata K., Ibaraki N., et al. Detection of cytotoxic anti-LEDGF autoantibodies in atopic dermatitis. Autoimmunity 2002, 35:319-327.
14. Fritzler M.J. Challenges to the use of autoantibodies as predictors of disease onset, diagnosis and outcomes. Autoimmun Rev 2008, 7:616-620.
15. Koenig M., Dieude M., Senecal J.L. Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies. Autoimmun Rev 2008, 7:588-593.
16. Mariz H.A., Sato E.I., Barbosa S.H., Rodrigues S.H., Dellavance A., Andrade L.E. Ana HEp-2 pattern is a critical parameter for discriminating ana-positive healthy individuals and patients with autoimmune rheumatic diseases. Arthritis Rheum 2010, 63:191-200.
17. Muro Y., Sugiura K., Morita Y., Tomita Y. High concomitance of disease marker autoantibodies in anti-DFS70/LEDGF autoantibody-positive patients with autoimmune rheumatic disease. Lupus 2008, 17:171-176.
18. Muro Y., Ogawa Y., Sugiura K., Tomita Y. HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease. J Autoimmun 2006, 26:252-257.
19. Ochs R.L., Stein T.W., Peebles C.L., Gittes R.F., Tan E.M. Autoantibodies in interstitial cystitis. J Urol 1994, 151:587-592.
20. Shinohara T., Singh D.P., Chylack L.T. Review: age-related cataract: immunity and lens epithelium-derived growth factor (LEDGF). J Ocul Pharmacol Ther 2000, 16:181-191.
21. Maertens G., Cherepanov P., Pluymers W., Busschots K., De C.E., Debyser Z., et al. LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J Biol Chem 2003, 278:33528-33539.
22. Bossuyt X., Frans J., Hendrickx A., Godefridis G., Westhovens R., Marien G. Detection of anti-SSA antibodies by indirect immunofluorescence. Clin Chem 2004, 50:2361-2369.
23. Hiemann R., Buttner T., Krieger T., Roggenbuck D., Sack U., Conrad K. Challenges of automated screening and differentiation of non-organ specific autoantibodies on HEp-2 cells. Autoimmun Rev 2009, 9:17-22.
24. Rigon A., Buzzulini F., Soda P., Onofri L., Arcarese L., Iannello G., et al. Novel opportunities in automated classification of antinuclear antibodies on HEp-2 cells. Autoimmun Rev 2011, 10:647-652.
25. Bonaguri C., Melegari A., Ballabio A., Parmeggiani M., Russo A., Battistelli L., et al. Italian multicentre study for application of a diagnostic algorithm in autoantibody testing for autoimmune rheumatic disease: conclusive results. Autoimmun Rev 2011 Nov, 11(1):1-5. Epub 2011 Jun 28.
26. Bizzaro N., Tonutti E., Visentini D., Alessio M.G., Platzgummer S., Morozzi G., et al. Antibodies to the lens and cornea in anti-DFS70-positive subjects. Ann N Y Acad Sci 2007, 1107:174-183.
27. Arbuckle M.R., McClain M.T., Rubertone M.V., Scofield R.H., Dennis G.J., James J.A., et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003, 349:1526-1533.