Biochemical discrimination between selenium and sulfur 2: Mechanistic investigation of the selenium specificity of human selenocysteine lyase

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Johansson, Ann Louise ^a   Collins, Ruairi ^b   Arnér, Elias S J ^b   Brzezinski, Peter ^a   Högbom, Martin ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

LYASE; SELENIUM; SELENOCYSTEINE LYASE; SULFUR; UNCLASSIFIED DRUG; SELENOCYSTEINE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GAIN OF FUNCTION MUTATION; GENETIC VARIABILITY; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; ULTRAVIOLET SPECTROSCOPY; WILD TYPE; AMINO ACID SUBSTITUTION; BIOCHEMISTRY; BIOLOGICAL MODEL; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; BIOCHEMICAL PHENOMENA; CATALYSIS; CATALYTIC DOMAIN; HUMANS; LYASES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SELENIUM; SELENOCYSTEINE; SUBSTRATE SPECIFICITY; SULFUR;

EID: 84861741119     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030528     Document Type: Article

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