Biochemical discrimination between selenium and sulfur 1: A single residue provides selenium specificity to human selenocysteine lyase

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Collins, Ruairi ^a   Johansson, Ann Louise ^b   Karlberg, Tobias ^a   Markova, Natalia ^a   van den Berg, Susanne ^a   Olesen, Kenneth ^a,c   Hammarström, Martin ^a   Flores, Alex ^a   Schüler, Herwig ^a   Schiavone, Lovisa Holmberg ^a,d   Brzezinski, Peter ^b   Arnér, Elias S J ^a   Högbom, Martin ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c NANOXIS CONSULTING AB   (Sweden)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CYSTATHIONINE GAMMA LYASE; CYSTEINE; LYASE; SELENIDE; SELENIUM; SELENOCYSTEINE; SELENOCYSTEINE LYASE; SELENOPROTEIN; SULFUR; UNCLASSIFIED DRUG;

ARTICLE; ATOM; BIOCHEMICAL COMPOSITION; CHEMICAL ANALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE SEQUENCE; HUMAN; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RESIDUE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; RAT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; LYASES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RATS; SELENIUM; SUBSTRATE SPECIFICITY; SULFUR;

EID: 84861954783     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030581     Document Type: Article

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